Search Results - "Kochevar, Irene E."

UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells by Liu, Cailing, Vojnovic, Dijana, Kochevar, Irene E, Jurkunas, Ula V

“…To examine whether Nrf2-regulated antioxidant defense and p53 are activated in human corneal endothelial cells (CEnCs) by environmental levels of ultraviolet A…”
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Nox1-Based NADPH Oxidase Is the Major Source of UVA-Induced Reactive Oxygen Species in Human Keratinocytes by Valencia, Antonio, Kochevar, Irene E.

“…UVA radiation is a major environmental stress on skin, causing acute and chronic photodamage. These responses are mediated by reactive oxygen species (ROS),…”
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Decreased DJ-1 leads to impaired Nrf2-regulated antioxidant defense and increased UV-A-induced apoptosis in corneal endothelial cells by Liu, Cailing, Chen, Yuming, Kochevar, Irene E, Jurkunas, Ula V

“…To investigate the role of DJ-1 in Nrf2-regulated antioxidant defense in corneal endothelial cells (CECs) at baseline and in response to ultraviolet A…”
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Influence of Rose Bengal Dimerization on Photosensitization by Mendes, Bryan, Kassumeh, Stefan, Aguirre‐Soto, Alan, Pei, Qing, Heyne, Belinda, Kochevar, Irene E.

“…Protein crosslinking photosensitized by rose Bengal (RB2−) has multiple medical applications and understanding the photosensitization mechanism can improve…”
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Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes by Yamaura, Maki, Yao, Min, Yaroslavsky, Ilya, Cohen, Richard, Smotrich, Michael, Kochevar, Irene E.

“…Background and Objective Low level light therapy (LLLT) is being evaluated for treating chronic and acute pain associated with rheumatoid arthritis (RA) and…”
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Rose Bengal Binding to Collagen and Tissue Photobonding by Alarcon, Emilio I, Poblete, Horacio, Roh, HeeGwang, Couture, Jean-François, Comer, Jeffrey, Kochevar, Irene E

“…We investigated two critical aspects of rose Bengal (RB) photosensitized protein cross-linking that may underlie recently developed medical applications. Our…”
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Ultraviolet A induces apoptosis via reactive oxygen species in a model for Smith–Lemli–Opitz syndrome by Valencia, Antonio, Kochevar, Irene E.

“…Solar ultraviolet A (UVA) radiation induces many responses in skin including oxidative stress, DNA damage, inflammation, and skin cancer. Smith–Lemli–Opitz…”
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Medical Applications of Rose Bengal‐ and Riboflavin‐Photosensitized Protein Crosslinking by Redmond, Robert W., Kochevar, Irene E.

“…This review summarizes research on many of the potential applications of photosensitized crosslinking of tissue proteins in surgery and current knowledge of…”
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Microvascular anastomosis using a photochemical tissue bonding technique by O'Neill, Anne C., Winograd, Jonathan M., Zeballos, José L., Johnson, T. Shane, Randolph, Mark A., Bujold, Kenneth E., Kochevar, Irene E., Redmond, Robert W.

“…Background and Objectives Photochemical tissue bonding (PTB) combines photoactive dyes with visible light to create fluid‐tight seals between tissue surfaces…”
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Corneal Biomechanical Response Following Collagen Cross-Linking With Rose Bengal-Green Light and Riboflavin-UVA by Bekesi, Nandor, Kochevar, Irene E, Marcos, Susana

“…To compare the biomechanical corneal response of two different corneal cross-linking (CXL) treatments, rose bengal-green light (RGX) and riboflavin-UVA (UVX),…”
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Improving electrophysiologic and histologic outcomes by photochemically sealing amnion to the peripheral nerve repair site by Henry, Francis P., MD, Goyal, Namita A., MD, David, William S., MD, PhD, Wes, David, BA, Bujold, Kenneth E., BS, Randolph, Mark A., MAS, Winograd, Jonathan M., MD, Kochevar, Irene E., PhD, Redmond, Robert W., PhD

“…Background The surgical approach used today in the repair of peripheral nerve injuries rarely achieves full functional recovery. This study determines whether…”
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Photochemical Sealing Improves Outcome Following Peripheral Neurorrhaphy by O'Neill, Anne C., M.D, Randolph, Mark A., M.A.S, Bujold, Kenneth E., B.S, Kochevar, Irene E., Ph.D, Redmond, Robert W., Ph.D, Winograd, Jonathan M., M.D

“…Introduction Peripheral nerve transection initiates a complex molecular response in the severed nerve endings, resulting in the release of neurotrophic and…”
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Spatially Resolved Cellular Responses to Singlet Oxygen by Redmond, Robert W., Kochevar, Irene E.

“…Singlet oxygen (1O2) is unique amongst reactive oxygen species formed in cells in that it is an excited state molecule with an inherent upper lifetime of 4 μs…”
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Corneal Crosslinking With Rose Bengal and Green Light: Efficacy and Safety Evaluation by Zhu, Hong, Alt, Clemens, Webb, Robert H, Melki, Samir, Kochevar, Irene E

“…PURPOSE:To evaluate crosslinking of cornea in vivo using green light activation of Rose Bengal (RGX) and assess potential damaging effects of the green light…”
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Photochemical Tissue Bonding: A Promising Technique for Peripheral Nerve Repair by Johnson, T. Shane, M.D, O’Neill, Anne C., M.D, Motarjem, Pejman M., B.S, Amann, Christopher, B.S, Nguyen, Tuan, B.S, Randolph, Mark A., M.A.S, Winograd, Jonathan M., M.D, Kochevar, Irene E., Ph.D, Redmond, Robert W., Ph.D

“…Background Photochemical tissue bonding (PTB) is a novel tissue repair technique that uses visible light and a photosensitizing dye to crosslink proteins on…”
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Enhancing Rose Bengal-Photosensitized Protein Crosslinking in the Cornea by Wertheimer, Christian M, Elhardt, Carolin, Kaminsky, Steffen M, Pham, Linh, Pei, Qing, Mendes, Bryan, Afshar, Sepideh, Kochevar, Irene E

“…Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and…”
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Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking by Germann, James A, Martínez-Enríquez, Eduardo, Martínez-García, M Carmen, Kochevar, Irene E, Marcos, Susana

“…Photoactivated cornea collagen cross-linking (CXL) increases corneal stiffness by initiating formation of covalent bonds between stromal proteins. Because CXL…”
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Collagen cross-linking using rose bengal and green light to increase corneal stiffness by Cherfan, Daniel, Verter, E Eri, Melki, Samir, Gisel, Thomas E, Doyle, Jr, Francis J, Scarcelli, Giuliano, Yun, Seok Hyun, Redmond, Robert W, Kochevar, Irene E

“…Photochemical cross-linking of corneal collagen is an evolving treatment for keratoconus and other ectatic disorders. We evaluated collagen cross-linking by…”
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Nanocaging Rose Bengal to Inhibit Aggregation and Enhance Photo‐induced Oxygen Consumption by Alvarez‐Lopez, Constanza, Cavazos‐Elizondo, Daniela, Heyne, Belinda, Kochevar, Irene E., Aguirre‐Soto, Alan

“…Photosensitized crosslinking of proteins in tissues has many medical applications including sealing wounds, strengthening tissues, and beneficially altering…”
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Antimicrobial Blue Light Therapy for Infectious Keratitis: Ex Vivo and In Vivo Studies by Zhu, Hong, Kochevar, Irene E, Behlau, Irmgard, Zhao, Jie, Wang, Fenghua, Wang, Yucheng, Sun, Xiaodong, Hamblin, Michael R, Dai, Tianhong

“…To investigate the effectiveness of antimicrobial blue light (aBL) as an alternative or adjunctive therapeutic for infectious keratitis. We developed an ex…”
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