Search Results - "Kochetkov, S.N"

P228 HEPATITIS C VIRUS NS5A PROTEIN TRIGGERS OXIDATIVE STRESS BY INDUCING NADPH OXIDASES 1 AND 4 AND CYTOCHROME P450 2E1 by Smirnova, O.A, Ivanova, O.N, Mukhtarov, F, Bartosch, B, Kochetkov, S.N, Ivanov, A.V

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Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes,…”
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120 Development of New HIV Inhibitors by Kochetkov, S.N.

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Human herpes simplex virus: Life cycle and development of inhibitors by Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N.

“…WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes,…”
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Oxidative Stress during HIV Infection: Mechanisms and Consequences by Isaguliants, Maria G., Starodubova, Elizaveta S., Kochetkov, Sergey N., Ivanova, Olga N., Valuev-Elliston, Vladimir T., Ivanov, Alexander V., Bartosch, Birke

“…It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells. If increased to levels which…”
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Recent studies of T7 RNA polymerase mechanism by Kochetkov, S.N, Rusakova, E.E, Tunitskaya, V.L

“…Bacteriophage T7 RNA polymerase (T7 RNAP) is known to be one of the simplest enzymes catalyzing RNA synthesis. In contrast to most RNA polymerases known, this…”
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Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: A combinatorial approach by Valuev-Elliston, V. T., Kochetkov, S. N.

“…Highly active antiretroviral therapy (HAART) is one of the most effective means for fighting against HIV-infec- tion. HAART primarily targets HIV-1 reverse…”
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Synthesis of mixed ribo/deoxyribopolynucleotides by mutant T7 RNA polymerase by Gudima, S.O, Kostyuk, D.A, Grishchenko, O.I, Tunitskaya, V.L, Memelova, L.V, Kochetkov, S.N

“…Synthesis of deoxynucleotide-containing RNA-like single-stranded polynucleotides (dcRNAs) using the Y639F, S641A mutant of T7 RNA polymerase (T7 RNAP) was…”
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Mutant T7 RNA polymerase is capable of catalyzing DNA primer extension reaction by Rusakova, E.E, Tunitskaya, V.L, Memelova, L.V, Kochetkova, S.V, Kostyuk, D.A, Kochetkov, S.N

“…The mutant T7 RNA polymerase (T7 RNAP), containing two substitutions (Y639F, S641A) was earlier shown to utilize both rNTP and dNTP in a transcription-like…”
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Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis by Ivanov, Alexander V, Valuev-Elliston, Vladimir T, Tyurina, Daria A, Ivanova, Olga N, Kochetkov, Sergey N, Bartosch, Birke, Isaguliants, Maria G

“…Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver…”
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Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…The structure-function analysis of 36 methylenebisphosphonates (BPs) as inhibitors of the phosphorolytic activity of native and drug-resistant forms of HIV-1…”
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Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes by Kozlov, M. V., Kleymenova, A. A., Konduktorov, K. A., Malikova, A. Z., Kochetkov, S. N.

“…Acetylation of α-tubulin was studied in cultures of human hepatocytes under the influence of selective inhibitors of histone deacetylases HDAC6 and SIRT-2 —…”
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Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus by Korovina, A. N., Tunitskaya, V. L., Khomutov, M. A., Simonian, A. R., Khomutov, A. R., Ivanov, A. V., Kochetkov, S. N.

“…Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV)…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Ableto Over come the Barrier of Resistance to Acyclovir by Andronova, V L, Jasko, M V, Kukhanova, M K, Galegov, G A, Skoblov, Yr S, Kochetkov, S N

“…As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell…”
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Hepatitis C virus: The role of N-glycosylation sites of viral genotype 1b proteins for formation of viral particles in insect and mammalian cells by Beljelarskaya, S N, Orlova, O V, Drutsa, V L, Orlov, V A, Timohova, A V, Koroleva, N N, Popenko, V I, Ivanov, A V, Spirin, P V, Prassolov, V S, Rubtsov, P M, Kochetkov, S N

“…Hepatitis C virus (HCV) is characterized by considerable genetic variability and, as a consequence, it has 6 genotypes and multitude of subtypes. HCV envelope…”
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Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds by Tunitskaya, V L, Khomutov, A R, Kochetkov, S N, Kotovskaya, S K, Charushin, V N

“…Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form…”
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Synthesis and Anti-HIV-1 Activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil Derivatives by Paramonova, M. P., Babkov, D. A., Valuev-Elliston, V. T., Ivanov, A. V., Kochetkov, S. N., Pannecouque, C., Ozerov, A. A., Balzarini, J., Novikov, M. S.

“…1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4- bis (trimethylsilyloxy)pyrimidine and…”
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Synthesis and biological activity of new 6-benzylisocytosine derivatives: non-nucleoside HIV-1 reverse transcriptase inhibitors by Valuev-Elliston, V. T., Ivanov, A. V., Orlinson, B. S., Gerasimov, E. N., Brunilina, L. L., Kochetkov, S. N., Novakov, I. A., Navrotskii, M. B.

“…New 6-benzylisocytosine derivatives were synthesized by aminolysis of 6-benzyl-2-(methylsulfanyl)pyrimidin-4(3 H )-ones with aliphatic aromatic and…”
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Screening of Potential HIV-1 Inhibitors/Replication Blockers Using Secure Lentiviral in Vitro System by Prokofjeva, M M, Spirin, P V, Yanvarev, D V, Ivanov, A V, Novikov, M S, Stepanov, O A, Gottikh, M B, Kochetkov, S N, Fehse, B, Stocking, C, Prassolov, V S

“…The development and usage of safe cell systems for testing agents which possess anti-HIV activity is a very important factor in the design of new drugs. We…”
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