Search Results - "Kochetkov, S. N."
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Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
Published in Doklady. Biochemistry and biophysics (01-12-2022)“…A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and…”
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Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication
Published in Doklady. Biochemistry and biophysics (01-04-2023)“…The synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-,…”
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Human herpes simplex virus: Life cycle and development of inhibitors
Published in Biochemistry (Moscow) (01-12-2014)“…WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes,…”
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Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells
Published in Molecular biology (New York) (01-05-2016)“…Hepatitis C virus (HCV) is a widespread dangerous human pathogen. Up to 80% of HCV-infected individuals develop chronic infection, which is often accompanied…”
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Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds
Published in Actanaturae (01-10-2011)“…Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form…”
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How Histone Deacetylase 3 Controls Hepcidin Expression and Hepatitis C Virus Replication
Published in Molecular biology (New York) (01-06-2023)“…The key role of histone deacetylases (HDAC) in the regulation of the cellular response to infection with the hepatitis C virus (HCV) was first demonstrated in…”
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Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: A combinatorial approach
Published in Biochemistry (Moscow) (01-12-2017)“…Highly active antiretroviral therapy (HAART) is one of the most effective means for fighting against HIV-infec- tion. HAART primarily targets HIV-1 reverse…”
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RNA-dependent RNA polymerase of hepatitis C virus: Study on inhibition by α,γ-diketo acid derivatives
Published in Biochemistry (Moscow) (01-08-2009)“…It is supposed that α,γ-diketo acids (DKAs) inhibit the activity of hepatitis C virus RNA-dependent RNA poly-merase (RdRP HCV) via chelation of catalytic…”
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Cytotoxicity Studies of 5-Arylaminouracil Derivatives
Published in Molecular biology (New York) (01-04-2024)“…We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The…”
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5-Alkyloxymethyl Derivatives of 2ʹ-Deoxyuridine Bearing 2,4-Dinitrophenyl and Dansyl Groups: Synthesis and Antibacterial Activity
Published in Russian journal of bioorganic chemistry (01-12-2023)“…Condensation of 3ʹ,5ʹ-di- O -acetyl-5-bromomethyl-2ʹ-deoxyuridine with 6-trifluoroacetylaminohexan1-ol yielded…”
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Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine
Published in Molecular biology (New York) (01-08-2023)“…Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S -Adenosyl- L -methionine (AdoMet) is a main donor of the methyl group…”
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C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity
Published in Russian journal of bioorganic chemistry (01-11-2019)“…— Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of…”
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Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate
Published in Russian journal of bioorganic chemistry (01-07-2010)“…4′-Fluoro-2′,3′-O-isopropylidenecytidine was synthesized by the treatment of 5′-O-acetyl-4′-fluoro-2′,3′-O-isopropylideneuridine with triazole and…”
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14
Structural-functional analysis of bacteriophage T7 RNA polymerase
Published in Biochemistry (Moscow) (01-10-2002)“…This review summarizes our results of the structural and functional studies of bacteriophage T7 DNA-dependent RNA polymerase (T7 RNAP). Particular features of…”
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Therapy of HIV Infection: Current Approaches and Prospects
Published in Actanaturae (01-10-2016)“…The human immunodeficiency virus type 1 (HIV-1) is the causative agent of one of the most dangerous human diseases - the acquired immune deficiency syndrome…”
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Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs
Published in Molecular biology (New York) (01-06-2010)“…Primary structures of DNA polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates di ffering in…”
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New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2
Published in Molecular biology (New York) (2022)“…The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are…”
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Baculovirus vectors for efficient gene delivery and expression in mammalian cells
Published in Molecular biology (New York) (01-06-2010)“…Baculovirus expression vectors are extensively used for the delivery of foreign genes and expression of recombinant proteins in insect and mammalian cells…”
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Transcription and its regulation in mammalian and human mitochondria
Published in Molecular biology (New York) (01-04-2009)“…In eukaryotic cells, mitochondria are the primary source of ATP, which is generated by oxidative phosphorylation. Mammalian and human mitochondria contain…”
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Identification of a novel substrate-derived spermine oxidase inhibitor
Published in Actanaturae (01-07-2020)“…Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in M-mM concentrations in all eukaryotic cells, is precisely regulated by…”
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