Search Results - "Kochetkov, S. N."

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    Human herpes simplex virus: Life cycle and development of inhibitors by Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N.

    Published in Biochemistry (Moscow) (01-12-2014)
    “…WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes,…”
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    Effect of Hepatitis C virus proteins on the production of proinflammatory and profibrotic cytokines in Huh7.5 human hepatoma cells by Masalova, O. V., Lesnova, E. I., Permyakova, K. Yu, Samokhvalov, E. I., Ivanov, A. V., Kochetkov, S. N., Kushch, A. A.

    Published in Molecular biology (New York) (01-05-2016)
    “…Hepatitis C virus (HCV) is a widespread dangerous human pathogen. Up to 80% of HCV-infected individuals develop chronic infection, which is often accompanied…”
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    Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds by Tunitskaya, V L, Khomutov, A R, Kochetkov, S N, Kotovskaya, S K, Charushin, V N

    Published in Actanaturae (01-10-2011)
    “…Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form…”
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    How Histone Deacetylase 3 Controls Hepcidin Expression and Hepatitis C Virus Replication by Shcherbakova, A. S., Kochetkov, S. N., Kozlov, M. V.

    Published in Molecular biology (New York) (01-06-2023)
    “…The key role of histone deacetylases (HDAC) in the regulation of the cellular response to infection with the hepatitis C virus (HCV) was first demonstrated in…”
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    Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: A combinatorial approach by Valuev-Elliston, V. T., Kochetkov, S. N.

    Published in Biochemistry (Moscow) (01-12-2017)
    “…Highly active antiretroviral therapy (HAART) is one of the most effective means for fighting against HIV-infec- tion. HAART primarily targets HIV-1 reverse…”
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    RNA-dependent RNA polymerase of hepatitis C virus: Study on inhibition by α,γ-diketo acid derivatives by Kozlov, M. V, Polyakov, K. M, Filippova, S. E, Evstifeev, V. V, Lyudva, G. S, Kochetkov, S. N

    Published in Biochemistry (Moscow) (01-08-2009)
    “…It is supposed that α,γ-diketo acids (DKAs) inhibit the activity of hepatitis C virus RNA-dependent RNA poly-merase (RdRP HCV) via chelation of catalytic…”
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    Cytotoxicity Studies of 5-Arylaminouracil Derivatives by Kezin, V. A., Matyugina, E. S., Surzhikov, S. A., Novikov, M. S., Maslova, A. A., Karpenko, I. L., Ivanov, A. V., Kochetkov, S. N., Khandazhinskaya, A. L.

    Published in Molecular biology (New York) (01-04-2024)
    “…We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The…”
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    Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine by Filonov, V. L., Khomutov, M. A., Sergeev, A. V., Khandazhinskaya, A. L., Kochetkov, S. N., Gromova, E. S., Khomutov, A. R.

    Published in Molecular biology (New York) (01-08-2023)
    “…Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S -Adenosyl- L -methionine (AdoMet) is a main donor of the methyl group…”
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    C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity by Khomutov, M. A., Mikhura, I. V., Kochetkov, S. N., Khomutov, A. R.

    Published in Russian journal of bioorganic chemistry (01-11-2019)
    “…— Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of…”
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    Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate by Ivanov, M. A, Ludva, G. S, Mukovnya, A. V, Kochetkov, S. N, Tunitskaya, V. L, Alexandrova, L. A

    Published in Russian journal of bioorganic chemistry (01-07-2010)
    “…4′-Fluoro-2′,3′-O-isopropylidenecytidine was synthesized by the treatment of 5′-O-acetyl-4′-fluoro-2′,3′-O-isopropylideneuridine with triazole and…”
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    Structural-functional analysis of bacteriophage T7 RNA polymerase by Tunitskaya, V L, Kochetkov, S N

    Published in Biochemistry (Moscow) (01-10-2002)
    “…This review summarizes our results of the structural and functional studies of bacteriophage T7 DNA-dependent RNA polymerase (T7 RNAP). Particular features of…”
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    Therapy of HIV Infection: Current Approaches and Prospects by Prokofjeva, M M, Kochetkov, S N, Prassolov, V S

    Published in Actanaturae (01-10-2016)
    “…The human immunodeficiency virus type 1 (HIV-1) is the causative agent of one of the most dangerous human diseases - the acquired immune deficiency syndrome…”
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    Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs by Korovina, A. N, Gus'kova, A. A, Skoblov, M. Yu, Andronova, V. L, Galegov, G. A, Kochetkov, S. N, Kukhanova, M. K, Skoblov, Yu. S

    Published in Molecular biology (New York) (01-06-2010)
    “…Primary structures of DNA polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates di ffering in…”
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    New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2 by Maslova, A. A., Matyugina, E. C., Shustova, E. Yu, Volok, V. P., Kozlovskaya, L. I., Kochetkov, S. N., Khandazhinskaya, A. L.

    Published in Molecular biology (New York) (2022)
    “…The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are…”
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    Baculovirus vectors for efficient gene delivery and expression in mammalian cells by Koroleva, N. N, Spirin, P. V, Timokhova, A. V, Rubtzov, P. M, Kochetkov, S. N, Prasolov, V. S, Beljelarskaya, S. N

    Published in Molecular biology (New York) (01-06-2010)
    “…Baculovirus expression vectors are extensively used for the delivery of foreign genes and expression of recombinant proteins in insect and mammalian cells…”
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    Transcription and its regulation in mammalian and human mitochondria by Sologub, M. Yu, Kochetkov, S. N, Temiakov, D. E

    Published in Molecular biology (New York) (01-04-2009)
    “…In eukaryotic cells, mitochondria are the primary source of ATP, which is generated by oxidative phosphorylation. Mammalian and human mitochondria contain…”
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    Identification of a novel substrate-derived spermine oxidase inhibitor by Dunston, T. T., Khomutov, M. A., Gabelli, S. B., Stewart, T. M., Foley, J. R., Kochetkov, S. N., Khomutov, A. R., Casero Jr, R. A.

    Published in Actanaturae (01-07-2020)
    “…Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in M-mM concentrations in all eukaryotic cells, is precisely regulated by…”
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