Search Results - "Koch, Stacie S. Canan"

Activation of specific RXR heterodimers by an antagonist of RXR homodimers by Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A

“…Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent…”
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Enantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetals by Koch, Stacie S. Canan, Chamberlin, A. Richard

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Identification of the First Retinoid X Receptor Homodimer Antagonist by Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M

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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure by Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek

“…A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties…”
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Aza-retinoids as novel retinoid X receptor-specific agonists by Farmer, Luc J., Marron, Kristen S., Canan Koch, Stacie S., Hwang, C.K., Kallel, E Adam, Zhi, Lin, Nadzan, Alex M., Robertson, Dave W., Bennani, Youssef L.

“…A new structurally simple series of potent lipophilic aza-retinoid RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here…”
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Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells by Canan Koch, Stacie S, Dardashti, Laura J, Cesario, Rosemary M, Croston, Glenn E, Boehm, Marcus F, Heyman, Richard A, Nadzan, Alex M

“…A novel series of oxime ligands has been synthesized that displays potent, specific activation of the retinoid X receptors (RXRs). The oximes of 3-substituted…”
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Synthesis and structure-activity relationships of potent retinoid X receptor ligands by Farmer, Luc J., Jeong, Susan, Kallel, E.Adam, Canan Koch, Stacie S., Croston, Glenn E., Flatten, Karen S., Heyman, Rich A., Nadzan, Alex M.

“…A series of potent retinoid X receptor (RXR) selective ligands was designed and prepared. The lead compound 7a showed good binding (K i; 20–50 nM) and…”
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Synthesis of geometrically defined exocyclic olefins by Bennani, Youssef L., Hwang, C.-K., Canan Koch, Stacie S., Marron, Kristin S., Dar-ti, Laura J., Badea, Beth-Ann, Nadzan, Alex M.

“…The treatment of bicyclic and tricyclic ketones with lithium ethynyl acetylide, followed by the addition of a catalytic amount of CSA or p-TSA, affords the…”
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Stereoselective syntheses of lactones: (I) Enantioselective synthesis of substituted gamma-butyrolactones. (II) Alkoxide-directed methylation of lactones: Monocrotalic acid. (III) A macrolactonization transition state analogue by Canan Koch, Stacie S

“…An efficient and general enantioselective synthesis of $\beta$-alkyl $\gamma$-butyrolactones has been accomplished. The procedure includes an enantioselective…”
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