Search Results - "Koch, Richard C"

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    Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy by Mylari, Banavara L, Miller, Max W, Howes, Harold L, Figdor, Sanford K, Lynch, John E, Koch, Richard C

    Published in Journal of medicinal chemistry (01-04-1977)
    “…Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to…”
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    Journal Article
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    Anticoccidial derivatives of 6-azauracil. 5. Potentiation by benzophenone side chains by Carroll, Ronnie D, Miller, Max W, Mylari, Banavara L, Chappel, Larry R, Howes, Harold L, Lynch, Martin J, Lynch, John E, Gupta, Shyam K, Rash, Jay J, Koch, Richard C

    Published in Journal of medicinal chemistry (01-01-1983)
    “…Attachment of p-benzophenone side chains at N1 was found to be one of the most effective modifications for enhancing the potency of 6-azauracil against a broad…”
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    Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Lynch, John E, Lynch, Martin J, Koch, Richard C

    Published in Journal of medicinal chemistry (01-12-1979)
    “…Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were…”
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    Journal Article
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    Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Figdor, Sanford K, Lynch, Martin J, Lynch, John E, Gupta, Shyam K, Chappel, Larry R, Koch, Richard C

    Published in Journal of medicinal chemistry (01-11-1981)
    “…We report further progress in exploiting our earlier discovery that the anticoccidial activity of 6-azauracil increases markedly when appropriately substituted…”
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    Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Figdor, Sanford K, Lynch, Martin J, Lynch, John E, Koch, Richard C

    Published in Journal of medicinal chemistry (01-10-1980)
    “…A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides…”
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    Journal Article
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