Search Results - "Koch, Osvaldo"

The p53–p66shc–Manganese Superoxide Dismutase (MnSOD) network: A mitochondrial intrigue to generate reactive oxygen species by Pani, Giovambattista, Koch, Osvaldo Raùl, Galeotti, Tommaso

“…Once considered as a mere by-product of respiration, mitochondrial generation of reactive oxygen species (ROS) has recently emerged as a genetically controlled…”
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Oxidative stress and antioxidant defenses in ethanol-induced cell injury by Koch, Osvaldo R., Pani, Giovanni, Borrello, Silvia, Colavitti, Renata, Cravero, Amerys, Farrè, Stella, Galeotti, Tommaso

“…Although in the past several mechanisms and factors have been proposed to be responsible for alcoholic liver disease (ALD), at present the involvement of…”
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Role of the life span determinant P66 in ethanol-induced liver damage by Koch, Osvaldo R, Fusco, Salvatore, Ranieri, Sofia Chiatamone, Maulucci, Giuseppe, Palozza, Paola, Larocca, Luigi Maria, Cravero, Amerys A M, Farre', Stella M, De Spirito, Marco, Galeotti, Tommaso, Pani, Giovambattista

“…Mice lacking the 66 kDa isoform of the adapter molecule shcA (p66(shcA)) display increased resistance to oxidative stress and delayed aging. In cultured cell…”
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Molecular and genetic aspects of ethanol in human diet: a nutrient or a toxicant? by Pani, Giovambattista, Koch, Osvaldo Raùl, Galeotti, Tommaso

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Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice by Pani, Giovambattista, Fusco, Salvatore, Colavitti, Renata, Borrello, Silvia, Maggiano, Nicola, Cravero, Amerys A.M., Farré, Stella M., Galeotti, Tommaso, Koch, Osvaldo R.

“…Ethanol consumption represents a major risk factor for cancer development, and a significant fraction of hepatocarcinomas arises in alcoholic liver cirrhosis…”
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Cardiac mitochondrial function and tissue remodelling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats by Piotrkowski, Barbara, Koch, Osvaldo R, De Cavanagh, Elena M V, Fraga, César G

“…Renal and cardiac benefits of renin-angiotensin system inhibition exceed blood pressure (BP) reduction and seem to involve mitochondrial function. It has been…”
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Liver necrosis induced by acute intraperitoneal ethanol administration in aged rats by Giavarotti, Leandro, D'Almeida, Vania, Giavarotti, Karin A S, Azzalis, Ligia A, Rodrigues, Luciano, Cravero, Amerys A M, Videla, Luis A, Koch, Osvaldo R, Junqueira, Virginia B C

“…It is generally agreed that the deleterious pathophysiological effects of ethanol are caused, at least partially by an increase in free radical production…”
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Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication by Videla, Luis A, Arisi, Ana C.M, Fuzaro, Ana P, Koch, Osvaldo R, Junqueira, Virginia B.C

“…Lindane administration to rats (60 mg/kg b.w.) led to an enhancement in the oxidative stress status of the liver at 4 h after treatment, characterized by…”
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Regression of morphological alterations and oxidative stress-related parameters after acute lindane-induced hepatotoxicity in rats by Junqueira, Virginia B.C., Koch, Osvaldo R., Arisi, Ana Carolina M., Fuzaro, Ana Paula, Azzalis, Ligia A., Barros, Silvia B.M., Cravero, Amerys, Farré, Stella, Videla, Luis A.

“…Changes in rat liver oxidative stress-related parameters, morphological alterations, as well as circulating and tissue levels of lindane were studied 1–7 days…”
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Doctor Leonardo Pinchuk (1936 - 2009) by Osvaldo Koch

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Inducción de la superoxidodismutasa mitocondrial by Koch, Osvaldo

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Role of the life span determinant P66shcA in ethanol-induced liver damage by Koch, Osvaldo R, Fusco, Salvatore, Ranieri, Sofia Chiatamone, Maulucci, Giuseppe, Palozza, Paola, Larocca, Luigi Maria, Cravero, Amerys A M, Farre', Stella M, De Spirito, Marco, Galeotti, Tommaso, Pani, Giovambattista

“…Mice lacking the 66 kDa isoform of the adapter molecule shcA (p66 shcA ) display increased resistance to oxidative stress and delayed aging. In cultured cell…”
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Lindane-induced oxidative stress. I. Time course of changes in hepatic microsomal parameters, antioxidant enzymes, lipid peroxidative indices and morphological characteristics by Junqueira, V B, Simizu, K, Van Halsema, L, Koch, O R, Barros, S B, Videla, L A

“…1. Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O2-.) generation 24 h after treatment, while…”
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The Effect of Acute and Chronic Ethanol Administration on Prolactin Secretion in Male Rats by SEILICOVICH, ADRIANA, RETTORI, VALERIA, KOCH, OSVALDO R, DUVILANSKI, BEATRIZ, DIAZ, MARIA del C, DEBELJUK, LUCIANO

“…The effect of acute and chronic administration of ethanol on prolactin secretion in male rats was investigated under basal conditions and after the…”
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ANTIHBC: a predictive factor of cirrhosis in chronic hepatitis C by Pinchuk, Leonardo, Garcia, Daniel, Poncino, Daniel, Cravero, Amerys, Palermo, Cristina, Dans, Carlos Garcia, Koch, Osvaldo

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REGULATION OF MANGANESE SUPEROXIDE DISMUTASE (MnSOD) IN CHRONIC EXPERIMENTAL ALCOHOLISM: EFFECTS OF VITAMIN E-SUPPLEMENTED AND -DEFICIENT DIETS by Koch, Osvaldo, Farré, Stella, De Leo, Maria Emilia, Palozza, Paola, Palazzotti, Bernardetta, Borrelo, Silvia, Palombini, Guglielmo, Cravero, Ameris, Galeotti, Tommaso

“…In order to investigate the pathogenic mechanism responsible for liver injury associated with chronic alcoholism, we studied the effects of different dietary…”
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Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats by Boveris, A, Fraga, C G, Varsavsky, A I, Koch, O R

“…Rats fed ethanol (1.74 +/- 0.12 g/day/100 g body wt for 12 weeks) showed a 45% increased microsomal production of O-2 (2.23 +/- 0.14 nmol/min/mg protein) and a…”
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Effects of dietary protein on the liver of rats in experimental chronic alcoholism by Porta, E A, Koch, O R, Gomez-Dumm, C L, Hartroft, W S

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Increased biliary glutathione disulfide release in chronically ethanol-treated rats by Sies, Helmut, Koch, Osvaldo R., Martino, Elba, Boveris, Alberto

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Chemiluminescence of the in situ rat liver after acute ethanol intoxication--effect of (+)-cyanidanol-3 by Videla, L A, Fraga, C G, Koch, O R, Boveris, A

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