Search Results - "Koch, Manuel"

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients by Kreer, Christoph, Zehner, Matthias, Weber, Timm, Ercanoglu, Meryem S., Gieselmann, Lutz, Rohde, Cornelius, Halwe, Sandro, Korenkov, Michael, Schommers, Philipp, Vanshylla, Kanika, Di Cristanziano, Veronica, Janicki, Hanna, Brinker, Reinhild, Ashurov, Artem, Krähling, Verena, Kupke, Alexandra, Cohen-Dvashi, Hadas, Koch, Manuel, Eckert, Jan Mathis, Lederer, Simone, Pfeifer, Nico, Wolf, Timo, Vehreschild, Maria J.G.T., Wendtner, Clemens, Diskin, Ron, Gruell, Henning, Becker, Stephan, Klein, Florian

“…The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs and vaccines are limited…”
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Gene Expression Profiling of the Extracellular Matrix Signature in Macrophages of Different Activation Status: Relevance for Skin Wound Healing by Etich, Julia, Koch, Manuel, Wagener, Raimund, Zaucke, Frank, Fabri, Mario, Brachvogel, Bent

“…The extracellular matrix (ECM) provides structural support for tissue architecture and is a major effector of cell behavior during skin repair and…”
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Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response by Morey, Pau, Pfannkuch, Lennart, Pang, Ervinna, Boccellato, Francesco, Sigal, Michael, Imai-Matsushima, Aki, Dyer, Victoria, Koch, Manuel, Mollenkopf, Hans-Joachim, Schlaermann, Philipp, Meyer, Thomas F.

“…Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of…”
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Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils by Chiquet, Matthias, Birk, David E., Bönnemann, Carsten G., Koch, Manuel

“…Collagen XII, largest member of the fibril-associated collagens with interrupted triple helix (FACIT) family, assembles from three identical α-chains encoded…”
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Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies by Heide, Fabian, Koch, Manuel, Stetefeld, Jörg

“…Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the…”
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Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis by Koch, Manuel, Mollenkopf, Hans-Joachim, Klemm, Uwe, Meyer, Thomas F

“…Helicobacter pylori is a gastric pathogen responsible for a high disease burden worldwide. Deregulated inflammatory responses, possibly involving macrophages,…”
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Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function by Izu, Yayoi, Adams, Sheila M., Connizzo, Brianne K., Beason, David P., Soslowsky, Louis J., Koch, Manuel, Birk, David E.

“…•Collagen XII is localized both in the tendon matrix and associated with tenocytes in developing, maturing and mature tendons.•Collagen XII regulates collagen…”
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Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay by Schermer, Bernhard, Fabretti, Francesca, Damagnez, Maximilian, Di Cristanziano, Veronica, Heger, Eva, Arjune, Sita, Tanner, Nathan A, Imhof, Thomas, Koch, Manuel, Ladha, Alim, Joung, Julia, Gootenberg, Jonathan S, Abudayyeh, Omar O, Burst, Volker, Zhang, Feng, Klein, Florian, Benzing, Thomas, Müller, Roman-Ulrich

“…Rapid and extensive testing of large parts of the population and specific subgroups is crucial for proper management of severe acute respiratory syndrome…”
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Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D by Mayorca-Guiliani, Alejandro E, Willacy, Oliver, Madsen, Chris D., Rafaeva, Maria, Elisabeth Heumüller, Stefanie, Bock, Felix, Sengle, Gerhard, Koch, Manuel, Imhof, Thomas, Zaucke, Frank, Wagener, Raimund, Sasaki, Takako, Erler, Janine T., Reuten, Raphael

“…The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of…”
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ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System by Zimmermann, Stephanie, Pfannkuch, Lennart, Al-Zeer, Munir A., Bartfeld, Sina, Koch, Manuel, Liu, Jianping, Rechner, Cindy, Soerensen, Meike, Sokolova, Olga, Zamyatina, Alla, Kosma, Paul, Mäurer, André P., Glowinski, Frithjof, Pleissner, Klaus-Peter, Schmid, Monika, Brinkmann, Volker, Karlas, Alexander, Naumann, Michael, Rother, Marion, Machuy, Nikolaus, Meyer, Thomas F.

“…Activation of transcription factor NF-κB is a hallmark of infection with the gastric pathogen Helicobacter pylori, associated with inflammation and…”
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Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development by Vallecillo-García, Pedro, Orgeur, Mickael, vom Hofe-Schneider, Sophie, Stumm, Jürgen, Kappert, Verena, Ibrahim, Daniel M., Börno, Stefan T., Hayashi, Shinichiro, Relaix, Frédéric, Hildebrandt, Katrin, Sengle, Gerhard, Koch, Manuel, Timmermann, Bernd, Marazzi, Giovanna, Sassoon, David A., Duprez, Delphine, Stricker, Sigmar

“…Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal muscle that support muscle regeneration. During development,…”
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Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth by Pach, Elke, Kümper, Maike, Fromme, Julia E, Zamek, Jan, Metzen, Fabian, Koch, Manuel, Mauch, Cornelia, Zigrino, Paola

“…Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer…”
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Identification of a myofibroblast-specific expression signature in skin wounds by Bergmeier, Vera, Etich, Julia, Pitzler, Lena, Frie, Christian, Koch, Manuel, Fischer, Matthias, Rappl, Gunter, Abken, Hinrich, Tomasek, James J., Brachvogel, Bent

“…After skin injury fibroblasts migrate into the wound and transform into contractile, extracellular matrix-producing myofibroblasts to promote skin repair…”
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Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers by Vanshylla, Kanika, Fan, Chengcheng, Wunsch, Marie, Poopalasingam, Nareshkumar, Meijers, Matthijs, Kreer, Christoph, Kleipass, Franziska, Ruchnewitz, Denis, Ercanoglu, Meryem S., Gruell, Henning, Münn, Friederike, Pohl, Kai, Janicki, Hanna, Nolden, Tobias, Bartl, Simone, Stein, Saskia C., Augustin, Max, Dewald, Felix, Gieselmann, Lutz, Schommers, Philipp, Schulz, Thomas F., Sander, Leif Erik, Koch, Manuel, Łuksza, Marta, Lässig, Michael, Bjorkman, Pamela J., Klein, Florian

“…A fraction of COVID-19 convalescent individuals mount a potent antibody response to SARS-CoV-2 with cross-reactivity to SARS-CoV-1. To uncover their humoral…”
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Collagen XII and XIV, New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure by Agarwal, Pallavi, Zwolanek, Daniela, Keene, Douglas R., Schulz, Jan-Niklas, Blumbach, Katrin, Heinegård, Dick, Zaucke, Frank, Paulsson, Mats, Krieg, Thomas, Koch, Manuel, Eckes, Beate

“…The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures…”
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Differential Proteomic Analysis Distinguishes Tissue Repair Biomarker Signatures in Wound Exudates Obtained from Normal Healing and Chronic Wounds by Eming, Sabine A, Koch, Manuel, Krieger, Andreas, Brachvogel, Bent, Kreft, Sandra, Bruckner-Tuderman, Leena, Krieg, Thomas, Shannon, John D, Fox, Jay W

“…Chronic wounds associated with vascular disease, diabetes mellitus, or aging are leading causes of morbidity in western countries and represent an unresolved…”
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Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction by Charvet, Benjamin, Guiraud, Alexandre, Malbouyres, Marilyne, Zwolanek, Daniela, Guillon, Emilie, Bretaud, Sandrine, Monnot, Catherine, Schulze, Jörg, Bader, Hannah L, Allard, Bruno, Koch, Manuel, Ruggiero, Florence

“…The myotendinous junction (MTJ) is the major site of force transfer in skeletal muscle, and defects in its structure correlate with a subset of muscular…”
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Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients by Kreer, Christoph, Zehner, Matthias, Weber, Timm, Ercanoglu, Meryem S., Gieselmann, Lutz, Rohde, Cornelius, Halwe, Sandro, Korenkov, Michael, Schommers, Philipp, Vanshylla, Kanika, Di Cristanziano, Veronica, Janicki, Hanna, Brinker, Reinhild, Ashurov, Artem, Krähling, Verena, Kupke, Alexandra, Cohen-Dvashi, Hadas, Koch, Manuel, Eckert, Jan Mathis, Lederer, Simone, Pfeifer, Nico, Wolf, Timo, Vehreschild, Maria J.G.T., Wendtner, Clemens, Diskin, Ron, Gruell, Henning, Becker, Stephan, Klein, Florian

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Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19 by Meinberger, Denise, Koch, Manuel, Roth, Annika, Hermes, Gabriele, Stemler, Jannik, Cornely, Oliver A., Streichert, Thomas, Klatt, Andreas R.

“…Immunoassays are a standard diagnostic tool that assesses immunity in severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection. However,…”
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Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers by Grandin, Mélodie, Meier, Markus, Delcros, Jean Guy, Nikodemus, Denise, Reuten, Raphael, Patel, Trushar R., Goldschneider, David, Orriss, George, Krahn, Natalie, Boussouar, Amina, Abes, Riad, Dean, Yann, Neves, David, Bernet, Agnes, Depil, Stephane, Schneiders, Fiona, Poole, Kate, Dante, Robert, Koch, Manuel, Mehlen, Patrick, Stetefeld, Jörg

“…Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of…”
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