Search Results - "Koch, Jana"

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells by Koch, Jana, Uckeley, Zina M, Doldan, Patricio, Stanifer, Megan, Boulant, Steeve, Lozach, Pierre‐Yves

“…SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in early 2020. COVID‐19 is primarily associated with lung injury, but many…”
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Advances and recent developments in asthma in 2020 by Cevhertas, Lacin, Ogulur, Ismail, Maurer, Debbie J., Burla, Daniel, Ding, Mei, Jansen, Kirstin, Koch, Jana, Liu, Chengyao, Ma, Siyuan, Mitamura, Yasutaka, Peng, Yaqi, Radzikowska, Urszula, Rinaldi, Arturo O., Satitsuksanoa, Pattraporn, Globinska, Anna, Veen, Willem, Sokolowska, Milena, Baerenfaller, Katja, Gao, Ya‐dong, Agache, Ioana, Akdis, Mübeccel, Akdis, Cezmi A.

“…In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and…”
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Advances and highlights in biomarkers of allergic diseases by Ogulur, Ismail, Pat, Yagiz, Ardicli, Ozge, Barletta, Elena, Cevhertas, Lacin, Fernandez‐Santamaria, Ruben, Huang, Mengting, Bel Imam, Manal, Koch, Jana, Ma, Siyuan, Maurer, Debbie J., Mitamura, Yasutaka, Peng, Yaqi, Radzikowska, Urszula, Rinaldi, Arturo O., Rodriguez‐Coira, Juan, Satitsuksanoa, Pattraporn, Schneider, Stephan R., Wallimann, Alexandra, Zhakparov, Damir, Ziadlou, Reihane, Brüggen, Marie‐Charlotte, Veen, Willem, Sokolowska, Milena, Baerenfaller, Katja, Zhang, Luo, Akdis, Mubeccel, Akdis, Cezmi A.

“…During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of…”
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Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling by Wieghofer, Peter, Hagemeyer, Nora, Sankowski, Roman, Schlecht, Anja, Staszewski, Ori, Amann, Lukas, Gruber, Markus, Koch, Jana, Hausmann, Annika, Zhang, Peipei, Boneva, Stefaniya, Masuda, Takahiro, Hilgendorf, Ingo, Goldmann, Tobias, Böttcher, Chotima, Priller, Josef, Rossi, Fabio MV, Lange, Clemens, Prinz, Marco

“…Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐resident macrophages provide the major immune cell constituents. However,…”
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Three dimensional cultivation increases chemo- and radioresistance of colorectal cancer cell lines by Koch, Jana, Mönch, Dina, Maaß, Annika, Gromoll, Christian, Hehr, Thomas, Leibold, Tobias, Schlitt, Hans J, Dahlke, Marc-H, Renner, Philipp

“…Although 2D cell cultures are commonly used to predict therapy response, it has become clear that 3D cultures may better mimic the in vivo situation and offer…”
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The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells by Koch, Jana, Xin, Qilin, Obr, Martin, Schäfer, Alicia, Rolfs, Nina, Anagho, Holda A, Kudulyte, Aiste, Woltereck, Lea, Kummer, Susann, Campos, Joaquin, Uckeley, Zina M, Bell-Sakyi, Lesley, Kräusslich, Hans-Georg, Schur, Florian Km, Acuna, Claudio, Lozach, Pierre-Yves

“…Toscana virus is a major cause of arboviral disease in humans in the Mediterranean basin during summer. However, early virus-host cell interactions and entry…”
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Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus by Koch, Jana, Schober, Sebastian J., Hindupur, Sruthi V., Schöning, Caroline, Klein, Florian G., Mantwill, Klaus, Ehrenfeld, Maximilian, Schillinger, Ulrike, Hohnecker, Timmy, Qi, Pan, Steiger, Katja, Aichler, Michaela, Gschwend, Jürgen E., Nawroth, Roman, Holm, Per Sonne

“…CDK4/6 inhibitors (CDK4/6i) and oncolytic viruses are promising therapeutic agents for the treatment of various cancers. As single agents, CDK4/6 inhibitors…”
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Entry of Phenuiviruses into Mammalian Host Cells by Koch, Jana, Xin, Qilin, Tischler, Nicole D, Lozach, Pierre-Yves

“…is a large family of arthropod-borne viruses with over 100 species worldwide. Several cause severe diseases in both humans and livestock. Global warming and…”
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NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice by Léger, Psylvia, Nachman, Eliana, Richter, Karsten, Tamietti, Carole, Koch, Jana, Burk, Robin, Kummer, Susann, Xin, Qilin, Stanifer, Megan, Bouloy, Michèle, Boulant, Steeve, Kräusslich, Hans-Georg, Montagutelli, Xavier, Flamand, Marie, Nussbaum-Krammer, Carmen, Lozach, Pierre-Yves

“…Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to specific human illnesses such as Alzheimer’s disease. Here we…”
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Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body by Rosmus, Dennis-Dominik, Koch, Jana, Hausmann, Annika, Chiot, Aude, Arnhold, Franz, Masuda, Takahiro, Kierdorf, Katrin, Hansen, Stefanie Marie, Kuhrt, Heidrun, Fröba, Janine, Wolf, Julian, Boneva, Stefaniya, Gericke, Martin, Ajami, Bahareh, Prinz, Marco, Lange, Clemens, Wieghofer, Peter

“…The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as…”
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The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation by Zhang, Peipei, Schlecht, Anja, Wolf, Julian, Boneva, Stefaniya, Laich, Yannik, Koch, Jana, Ludwig, Franziska, Boeck, Myriam, Thien, Adrian, Härdtner, Carmen, Kierdorf, Katrin, Agostini, Hansjürgen, Schlunck, Günther, Prinz, Marco, Hilgendorf, Ingo, Wieghofer, Peter, Lange, Clemens

“…Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However,…”
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Validation of sTREM-1 and IL-6 based algorithms for outcome prediction of COVID-19 by Van Singer, Mathias, Brahier, Thomas, Koch, Jana, Hugli, Pr. Olivier, Weckman, Andrea M, Zhong, Kathleen, Kain, Taylor J, Leligdowicz, Aleksandra, Bernasconi, Enos, Ceschi, Alessandro, Parolari, Sara, Vuichard-Gysin, Danielle, Kain, Kevin C, Albrich, Werner C, Boillat-Blanco, Noémie

“…Abstract Background A prospective observational cohort study of COVID-19 patients in a single Emergency Department (ED) showed that sTREM-1- and IL-6-based…”
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Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review by Gerstl, Brigitte, Sullivan, Elizabeth, Vallejo, Marcus, Koch, Jana, Johnson, Maximilian, Wand, Handan, Webber, Kate, Ives, Angela, Anazodo, Antoinette

“…Purpose Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family…”
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Assessment of Substrate Status of Drugs Metabolized by Polymorphic Cytochrome P450 (CYP) 2 Enzymes: An Analysis of a Large-Scale Dataset by Sommer, Jakob, Wozniak, Justyna, Schmitt, Judith, Koch, Jana, Stingl, Julia C, Just, Katja S

“…The analysis of substrates of polymorphic cytochrome P450 (CYP) enzymes is important information to enable drug-drug interactions (DDIs) analysis and the…”
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Protocol for establishing a coculture with fibroblasts and colorectal cancer organoids by Wallisch, Svenja, Neef, Sylvia Karin, Denzinger, Lukas, Mönch, Dina, Koch, Jana, Marzi, Julia, Mürdter, Thomas, Janssen, Nicole

“…The tumor microenvironment is essential for mediating drug resistance and tumor progression. Here, we present a coculture system, which enables drug testing of…”
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Establishing a New Platform to Investigate the Efficacy of Oncolytic Virotherapy in a Human Ex Vivo Peritoneal Carcinomatosis Model by Koch, Jana, Beil, Julia, Berchtold, Susanne, Mönch, Dina, Maaß, Annika, Smirnow, Irina, Schenk, Andrea, Carter, Mary E, Kloker, Linus D, Leibold, Tobias, Renner, Philipp, Dahlke, Marc-H, Lauer, Ulrich M

“…Oncolytic virotherapy constitutes a promising treatment option for many solid cancers, including peritoneal carcinomatosis (PC), which still represents a…”
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STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy by Hindupur, Sruthi V, Schmid, Sebastian C, Koch, Jana Annika, Youssef, Ahmed, Baur, Eva-Maria, Wang, Dongbiao, Horn, Thomas, Slotta-Huspenina, Julia, Gschwend, Juergen E, Holm, Per Sonne, Nawroth, Roman

“…The JAK-STAT signalling pathway regulates cellular processes like cell division, cell death and immune regulation. Dysregulation has been identified in solid…”
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Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses by Woelfl, Franziska, Léger, Psylvia, Oreshkova, Nadia, Pahmeier, Felix, Windhaber, Stefan, Koch, Jana, Stanifer, Megan, Roman Sosa, Gleyder, Uckeley, Zina M, Rey, Felix A, Boulant, Steeve, Kortekaas, Jeroen, Wichgers Schreur, Paul J, Lozach, Pierre-Yves

“…The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we…”
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A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options by Mönch, Dina, Koch, Jana, Maaß, Annika, Janssen, Nicole, Mürdter, Thomas, Renner, Philipp, Fallier-Becker, Petra, Solaß, Wiebke, Schwab, Matthias, Dahlke, Marc-H., Schlitt, Hans J., Leibold, Tobias

“…Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of…”
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Influence of statins on cartilage homeostasis after traumatic impact and during chondrocyte re-differentiation by Riegger-Koch, Jana, Pulasani, Sai, Brenner, Rolf E.

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