Search Results - "Koch, Jakob"
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Unequivocal Mapping of Molecular Ether Lipid Species by LC–MS/MS in Plasmalogen-Deficient Mice
Published in Analytical chemistry (Washington) (18-08-2020)“…Deficient ether lipid biosynthesis in rhizomelic chondrodysplasia punctata and other disorders is associated with a wide range of severe symptoms including…”
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Phospholipid Acyl Chain Diversity Controls the Tissue-Specific Assembly of Mitochondrial Cardiolipins
Published in Cell reports (Cambridge) (24-03-2020)“…Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its acyl chain configurations are…”
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Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells
Published in Journal of lipid research (01-01-2021)“…The molecular assembly of cells depends not only on the balance between anabolism and catabolism but to a large degree on the building blocks available in the…”
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Erratum: Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells
Published in Journal of lipid research (01-04-2022)Get full text
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Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown
Published in Journal of lipid research (01-06-2022)“…Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether…”
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Tricky Isomers-The Evolution of Analytical Strategies to Characterize Plasmalogens and Plasmanyl Ether Lipids
Published in Frontiers in cell and developmental biology (27-04-2022)“…Typically, glycerophospholipids are represented with two esterified fatty acids. However, by up to 20%, a significant proportion of this lipid class carries an…”
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Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome
Published in Metabolites (27-11-2021)“…Patients with Marfan syndrome (MFS) have an increased risk of aortic aneurysm formation, dissection and development of a subtle cardiomyopathy. We analyzed…”
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Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle
Published in Therapeutic advances in chronic disease (2020)“…Background: Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid…”
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Changes in CREB phosphorylation and BDNF plasma levels during psychotherapy of depression
Published in Psychotherapy and psychosomatics (01-01-2009)“…The cyclic adenosine monophosphate response element-binding proteins (CREB) and their interaction with brain-derived neurotrophic factor (BDNF) are essential…”
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Pilot scale production of Hermetia illucens (L.) larvae and frass using former foodstuffs
Published in Cleaner Engineering and Technology (01-10-2022)“…The food and feed sector requires new sustainable sources of protein and innovative solutions for upcycling of food waste (former foodstuffs), which today is…”
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A flow-cytometric method to investigate glutamate-receptor-sensitivity in whole blood platelets – Results from healthy controls and patients with schizophrenia
Published in Journal of psychiatric research (01-03-2009)“…Abstract Hypofunction of glutamate receptors may contribute to the symptoms of schizophrenia. Human platelets express glutamate receptors and can serve as…”
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Changes in CREB-phosphorylation during recovery from major depression
Published in Journal of psychiatric research (01-11-2002)“…For decades psychiatrists have been looking for biological state markers measurable by easy blood test in order to follow up and predict early on treatment…”
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Sleep in major depression: relation to memory performance and outcome after interpersonal psychotherapy
Published in Neuropsychobiology (01-01-2007)“…Earlier findings suggest both a link between sleep and memory consolidation and a relationship between abnormal sleep at baseline and poor treatment outcome in…”
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Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability
Published in Journal of psychiatric research (2003)“…It has been shown that antidepressants increase the expression of CREB (cAMP-response-element-binding-protein) and BDNF (brain derived neurotrophic factor) in…”
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The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens
Published in Proceedings of the National Academy of Sciences - PNAS (07-04-2020)“…A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell…”
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What if … there were no special schools?: A spatial simulation study of inclusive school systems based on governmental data of Bavaria, Germany
Published in Zeitschrift für Grundschulforschung (23-09-2024)“…Abstract Inclusive education is a human right that involves restructuring the school system and closing special schools. However, there is uncertainty about…”
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Pathogenic cardiolipin alterations in Barth Syndrome enhance the cellular resistance against ferroptosis
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2024)Get full text
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PUFA-Induced Metabolic Enteritis as a Fuel for Crohn’s Disease
Published in Gastroenterology (New York, N.Y. 1943) (01-05-2022)“…Crohn’s disease (CD) globally emerges with Westernization of lifestyle and nutritional habits. However, a specific dietary constituent that comprehensively…”
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Depression as a major component of a gait disorder—Successful multimodal treatment including electroconvulsive therapy: A case report
Published in Zeitschrift für Gerontologie und Geriatrie (01-02-2023)“…This case report describes an 82-year-old patient who was treated in a gerontological psychiatric ward due to a multifactorial gait disorder with falls. The…”
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REM density is associated with treatment response in major depression: Antidepressant pharmacotherapy vs. psychotherapy
Published in Journal of psychiatric research (01-01-2021)“…Major depression is one of the most common psychiatric illnesses. Interestingly, a few studies have indicated the existence of depression subgroups, which…”
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