Search Results - "Koch, Hans P"

Multimeric nature of voltage-gated proton channels by Koch, Hans P, Kurokawa, Tatsuki, Okochi, Yoshifumi, Sasaki, Mari, Okamura, Yasushi, Larsson, H. Peter

“…Voltage-gated potassium channels are comprised of four subunits, and each subunit has a pore domain and a voltage-sensing domain (VSD). The four pore domains…”
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Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model by Larsson, H. Peter, Wang, Xiaoyu, Lev, Bogdan, Baconguis, Isabelle, Caplan, David A., Vyleta, Nicholas P., Koch, Hans P., Diez-Sampedro, Ana, Noskov, Sergei Y., Amara, Susan G.

“…Excitatory amino acid transporters (EAATs) remove glutamate from synapses. They maintain an efficient synaptic transmission and prevent glutamate from reaching…”
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Small-Scale Molecular Motions Accomplish Glutamate Uptake in Human Glutamate Transporters by Koch, Hans P, Larsson, H. Peter

“…Glutamate transporters remove glutamate from the synaptic cleft to maintain efficient synaptic communication between neurons and to prevent glutamate…”
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Fluorometric Measurements of Conformational Changes in Glutamate Transporters by Larsson, H Peter, Tzingounis, Anastassios V, Koch, Hans P, Kavanaugh, Michael P

“…Glutamate transporters remove glutamate from the synaptic cleft to maintain efficient synaptic communication between neurons and to prevent extracellular…”
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An Acid-activated Nucleobase Transporter from Leishmania major by Ortiz, Diana, Sanchez, Marco A., Koch, Hans P., Larsson, H. Peter, Landfear, Scott M.

“…Parasitic protozoa are unable to synthesize purines de novo and must import preformed purine nucleobases or nucleosides from their hosts. Leishmania major…”
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Voltage-independent Sodium-binding Events Reported by the 4B-4C Loop in the Human Glutamate Transporter Excitatory Amino Acid Transporter 3 by Koch, Hans P., Hubbard, Jeffrey M., Larsson, H. Peter

“…Glutamate transporters (excitatory amino acid transporter (EAATs)) are critical for normal excitatory signaling and maintaining subtoxic glutamate…”
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Strong cooperativity between subunits in voltage-gated proton channels by Larsson, H Peter, Gonzalez, Carlos, Koch, Hans P, Drum, Ben M

“…The voltage-gated proton channel Hv1 forms a dimer, but each monomer contains a voltage sensor domain that forms a pore for proton conduction. Now functional…”
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Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial by Fetsch, Thomas, Bauer, Peter, Engberding, Rolf, Koch, Hans P., Lukl, Jan, Meinertz, Thomas, Oeff, Michael, Seipel, Ludger, Trappe, Hans J., Treese, Norbert, Breithardt, Günter

“…Aims In patients with persistent atrial fibrillation (AF), the efficacy and safety of two anti-arrhythmic drugs in preventing the recurrence of AF after…”
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Methylation of l- trans-2,4-Pyrrolidine Dicarboxylate Converts the Glutamate Transport Inhibitor from a Substrate to a Non-substrate Inhibitor by Esslinger, C.Sean, Titus, Jody, Koch, Hans P., Bridges, Richard J., Chamberlin, A.Richard

“…The 4-methyl analogue of the potent inhibitor of CNS l-glutamate neurotransmitter transporters, l- trans-2,4-PDC, was synthesized via a 1,3-dipolar…”
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The substituted aspartate analogue l-β- threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3 by Esslinger, C. Sean, Agarwal, Shailesh, Gerdes, John, Wilson, Paul A., Davis, Erin S., Awes, Alicia N., O'Brien, Erin, Mavencamp, Teri, Koch, Hans P., Poulsen, David J., Rhoderick, Joseph F., Chamberlin, A. Richard, Kavanaugh, Michael P., Bridges, Richard J.

“…The excitatory amino acid transporters (EAATs) play key roles in the regulation of CNS l-glutamate, especially related to synthesis, signal termination,…”
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Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters by Koch, H P, Kavanaugh, M P, Esslinger, C S, Zerangue, N, Humphrey, J M, Amara, S G, Chamberlin, A R, Bridges, R J

“…Within the mammalian central nervous system, the efficient removal of L-glutamate from the extracellular space by excitatory amino acid transporters (EAATs)…”
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Strong Negative Cooperativity Between Subunits in Voltage-Gated Proton Channels by Gonzalez, Carlos, Koch, Hans P., Drum, Ben M., Larsson, Hans Peter

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Structural determinants of substrates and inhibitors : Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate by ESSLINGER, C. S, KOCH, H. P, KAVANAUGH, M. P, PHILIPS, D. P, CHAMBERLIN, A. R, THOMPSON, C. M, BRIDGES, R. J

“…Using an intramolecular [2 + 2] photocyclization, 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate…”
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Design and synthesis of conformationally constrained inhibitors of high-affinity, sodium-dependent glutamate transporters by Chamberlin, A R, Koch, H P, Bridges, R J

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Structural determinants of substrates and inhibitors: probing glutamate transporters with 2,4-methanopyrroldidine-2,4-dicarboxylate by Sean Esslinger, C., Koch, Hans P., Kavanaugh, Michael P., Philips, Dean P., Richard Chamberlin, A., Thompson, Charles M., Bridges, Richard J.

“…Using an intramolecular [2+2] photocyclization 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This…”
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The role of the C-4 side chain of kainate and dihydrokainate in EAA receptor and transporter selectivity by Sonnenberg, Jennifer D., Koch, Hans P., Willis, Colin L., Bradbury, Faye, Dauenhauer, Danielle, Bridges, Richard J., Chamberlin, A.Richard

“…Molecular modeling was used evaluate conformational effects of side chain modifications to kainate and the pharmacological consequences of such modifications…”
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