Search Results - "Koch, Evan M"

Population-specific causal disease effect sizes in functionally important regions impacted by selection by Shi, Huwenbo, Gazal, Steven, Kanai, Masahiro, Koch, Evan M., Schoech, Armin P., Siewert, Katherine M., Kim, Samuel S., Luo, Yang, Amariuta, Tiffany, Huang, Hailiang, Okada, Yukinori, Raychaudhuri, Soumya, Sunyaev, Shamil R., Price, Alkes L.

“…Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic…”
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Maintenance of Complex Trait Variation: Classic Theory and Modern Data by Koch, Evan M, Sunyaev, Shamil R

“…Numerous studies have found evidence that GWAS loci experience negative selection, which increases in intensity with the effect size of identified variants…”
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Polygenic adaptation of rosette growth in Arabidopsis thaliana by Wieters, Benedict, Steige, Kim A, He, Fei, Koch, Evan M, Ramos-Onsins, Sebastián E, Gu, Hongya, Guo, Ya-Long, Sunyaev, Shamil, de Meaux, Juliette

“…The rate at which plants grow is a major functional trait in plant ecology. However, little is known about its evolution in natural populations. Here, we…”
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The Effects of Demography and Genetics on the Neutral Distribution of Quantitative Traits by Koch, Evan M

“…Neutral models for quantitative trait evolution are useful for identifying phenotypes under selection. These models often assume normally distributed…”
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Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus by Commins, Nicoletta, Sullivan, Mark R, McGowen, Kerry, Koch, Evan M, Rubin, Eric J, Farhat, Maha

“…( ) is a multidrug-resistant pathogen increasingly responsible for severe pulmonary infections. Analysis of whole-genome sequences (WGS) of demonstrates dense…”
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A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription by Seplyarskiy, Vladimir, Koch, Evan M., Lee, Daniel J., Lichtman, Joshua S., Luan, Harding H., Sunyaev, Shamil R.

“…De novo mutations occur at substantially different rates depending on genomic location, sequence context and DNA strand. The success of methods to estimate…”
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De Novo Mutation Rate Estimation in Wolves of Known Pedigree by Koch, Evan M, Schweizer, Rena M, Schweizer, Teia M, Stahler, Daniel R, Smith, Douglas W, Wayne, Robert K, Novembre, John

“…Knowledge of mutation rates is crucial for calibrating population genetics models of demographic history in units of years. However, mutation rates remain…”
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Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population by Takou, Margarita, Hämälä, Tuomas, Koch, Evan M, Steige, Kim A, Dittberner, Hannes, Yant, Levi, Genete, Mathieu, Sunyaev, Shamil, Castric, Vincent, Vekemans, Xavier, Savolainen, Outi, Meaux, Juliette de

“…Abstract During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive…”
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Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts by Ciota, Alexander T., Koch, Evan M., Willsey, Graham G., Davis, Lauren J., Jerzak, Greta V.S., Ehrbar, Dylan J., Wilke, Claus O., Kramer, Laura D.

“…► Intrahost genetic diversity of primary SLEV mosquito isolates decreases over time. ► Recent SLEV mosquito isolates generally lack significant intrahost…”
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A biology-aware mutation rate model for human germline

“…We present a model to predict the chance of each possible de novo mutation in the human genome informed by recent insights into determinants of mutagenesis…”
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A biology-aware mutation rate model for human germline by Koch, Evan M, Seplyarskiy, Vladimir, Sunyaev, Shamil R

“…We present a model to predict the chance of each possible de novo mutation in the human genome informed by recent insights into determinants of mutagenesis…”
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Consequences and Scalings of Population History by Koch, Evan M

“…Population genomic data contains a startling amount of information about the demographic history of populations. As advances in statistical methodology for…”
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The effects of intentional hyperthermia on the Thrombelastograph and the Sonoclot analyser by Pivalizza, E G, Koch, S M, Mehlhorn, U, Berry, J M, Bull

“…The effect of whole-body hyperthermia (WBH) on viscoelastic properties of whole blood, as measured by the thrombelastogram (TEG) and Sonoclot analyser, was…”
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