Search Results - "Kobi Rosenblum"

PKR: A Kinase to Remember by Gal-Ben-Ari, Shunit, Barrera, Iliana, Ehrlich, Marcelo, Rosenblum, Kobi

“…Aging is a major risk factor for many diseases including metabolic syndrome, cancer, inflammation, and neurodegeneration. Identifying mechanistic common…”
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Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine by Adaikkan, Chinnakkaruppan, Taha, Elham, Barrera, Iliana, David, Orit, Rosenblum, Kobi

“…Ketamine is an N-methyl-D-aspartate receptor antagonist, which on administration produces fast-acting antidepressant responses in patients with major…”
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The Insula and Taste Learning by Yiannakas, Adonis, Rosenblum, Kobi

“…The sense of taste is a key component of the sensory machinery, enabling the evaluation of both the safety as well as forming associations regarding the…”
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Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation by Kayyal, Haneen, Yiannakas, Adonis, Kolatt Chandran, Sailendrakumar, Khamaisy, Mohammad, Sharma, Vijendra, Rosenblum, Kobi

“…Conditioned taste aversion (CTA) is an associative learning paradigm, wherein consumption of an appetitive tastant (e.g., saccharin) is paired to the…”
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Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits by Lavi, Karen, Jacobson, Gilad A., Rosenblum, Kobi, Lüthi, Andreas

“…Avoidance of potentially toxic food by means of conditioned taste aversion is critical for survival of many animals. However, the underlying neuronal…”
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The role of eEF2 pathway in learning and synaptic plasticity by Taha, Elham, Gildish, Iness, Gal-Ben-Ari, Shunit, Rosenblum, Kobi

“…One of the hallmarks of learning processes in any species studied so far is that they require intact protein synthesis machinery in order to consolidate…”
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A molecular mechanism underlying gustatory memory trace for an association in the insular cortex by Adaikkan, Chinnakkaruppan, Rosenblum, Kobi

“…Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay…”
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Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning in mice by Kayyal, Haneen, Chandran, Sailendrakumar Kolatt, Yiannakas, Adonis, Gould, Nathaniel, Khamaisy, Mohammad, Rosenblum, Kobi

“…To survive in an ever-changing environment, animals must detect and learn salient information. The anterior insular cortex (aIC) and medial prefrontal cortex…”
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Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties by Sharma, Vijendra, Ounallah-Saad, Hadile, Chakraborty, Darpan, Hleihil, Mohammad, Sood, Rapita, Barrera, Iliana, Edry, Efrat, Kolatt Chandran, Sailendrakumar, Ben Tabou de Leon, Shlomo, Kaphzan, Hanoch, Rosenblum, Kobi

“…Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known kinases that respond to cellular stress by deactivating the eukaryotic…”
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D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis by David, Orit, Barrera, Iliana, Gould, Nathaniel, Gal-Ben-Ari, Shunit, Rosenblum, Kobi

“…Dopamine, alongside other neuromodulators, defines brain and neuronal states, inter alia through regulation of global and local mRNA translation. Yet, the…”
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The roles of protein expression in synaptic plasticity and memory consolidation by Rosenberg, Tali, Gal-Ben-Ari, Shunit, Dieterich, Daniela C, Kreutz, Michael R, Ziv, Noam E, Gundelfinger, Eckart D, Rosenblum, Kobi

“…The amount and availability of proteins are regulated by their synthesis, degradation, and transport. These processes can specifically, locally, and temporally…”
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PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice by Segev, Yifat, Barrera, Iliana, Ounallah-Saad, Hadile, Wibrand, Karin, Sporild, Ida, Livne, Adva, Rosenberg, Tali, David, Orit, Mints, Meshi, Bramham, Clive R, Rosenblum, Kobi

“…Sporadic Alzheimer's disease (AD) is an incurable neurodegenerative disease with clear pathological hallmarks, brain dysfunction, and unknown etiology. Here,…”
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Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice by Gould, Nathaniel L, Scherer, Gila R, Carvalho, Silvia, Shurrush, Khriesto, Kayyal, Haneen, Edry, Efrat, Elkobi, Alina, David, Orit, Foqara, Maria, Thakar, Darshit, Pavesi, Tommaso, Sharma, Vijendra, Walker, Matthew, Maitland, Matthew, Dym, Orly, Albeck, Shira, Peleg, Yoav, Germain, Nicolas, Babaev, Ilana, Sharir, Haleli, Lalzar, Maya, Shklyar, Boris, Hazut, Neta, Khamaisy, Mohammad, Lévesque, Maxime, Lajoie, Gilles, Avoli, Massimo, Amitai, Gabriel, Lefker, Bruce, Subramanyam, Chakrapani, Shilton, Brian, Barr, Haim, Rosenblum, Kobi

“…Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD)…”
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Glycogen synthase kinase-3 inhibition is integral to long-term potentiation by Hooper, Claudie, Markevich, Vladimir, Plattner, Florian, Killick, Richard, Schofield, Emma, Engel, Tobias, Hernandez, Felix, Anderton, Brian, Rosenblum, Kobi, Bliss, Tim, Cooke, Sam F., Avila, Jesús, Lucas, José J., Giese, Karl Peter, Stephenson, John, Lovestone, Simon

“…Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating diverse cellular functions including metabolism, transcription and cell survival…”
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A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference by Beiser, Tehila, Lisniansky, Elvira, Weitz, Moriya, Bingor, Alexey, Grad, Etty, Rosenblum, Kobi, Thornton, Claire, Yaka, Rami

“…Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2…”
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Facilitation of Taste Memory Acquisition by Experiencing Previous Novel Taste Is Protein-Synthesis Dependent by Merhav, Maayan, Rosenblum, Kobi

“…Very little is known about the biological and molecular mechanisms that determine the effect of previous experience on implicit learning tasks. In the present…”
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Tyrosine Phosphorylation of the 2B Subunit of the NMDA Receptor Is Necessary for Taste Memory Formation by Barki-Harrington, Liza, Elkobi, Alina, Tzabary, Tali, Rosenblum, Kobi

“…We aimed to test whether tyrosine phosphorylation of the NMDA receptor (NMDAR) in the insular cortex is necessary for novel taste learning. We found that in…”
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c-Fos expression is elevated in GABAergic interneurons of the gustatory cortex following novel taste learning by Doron, Guy, Rosenblum, Kobi

“…Long-term sensory memories are considered to be stored in the relevant cortical region subserving the given modality. We and others have recently identified a…”
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Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly by Bresler, Tal, Shapira, Mika, Boeckers, Tobias, Dresbach, Thomas, Futter, Marie, Garner, Craig C, Rosenblum, Kobi, Gundelfinger, Eckart D, Ziv, Noam E

“…The cellular mechanisms involved in the formation of the glutamatergic postsynaptic density (PSD) are mainly unknown. Previous studies have indicated that PSD…”
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Specific and Differential Activation of Mitogen-Activated Protein Kinase Cascades by Unfamiliar Taste in the Insular Cortex of the Behaving Rat by Berman, Diego E, Hazvi, Shoshi, Rosenblum, Kobi, Seger, Rony, Dudai, Yadin

“…Rats were given to drink an unfamiliar taste solution under conditions that result in long-term memory of that taste. The insular cortex, which contains the…”
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