Efficacy of individual biocides and synergistic combinations

A method for quantitative estimation of the biocidal effect of compounds on microbial cells has been developed based on colony growth on solid nutrient media. The method allows for specifying a mode of action and for calculating the most effective ratio of biocides in synergistic blends. The test or...

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Bibliographic Details
Published in:	International biodeterioration & biodegradation Vol. 55; no. 4; pp. 253 - 259
Main Authors:	Rodin, V.B., Zhigletsova, S.K., Kobelev, V.S., Akimova, N.A., Kholodenko, V.P.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-06-2005
Subjects:	Colony growth model Copper sulfate Kathon Quantitative analysis Serratia marcescens Synergistic combinations Colony growth model Kathon Synergistic combinations Quantitative analysis Copper sulfate
Online Access:	Get full text
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Summary:	A method for quantitative estimation of the biocidal effect of compounds on microbial cells has been developed based on colony growth on solid nutrient media. The method allows for specifying a mode of action and for calculating the most effective ratio of biocides in synergistic blends. The test organism Serratia marcescens was grown in the presence of copper sulfate and kathon (2-N-octyl-4-isothiazolin-3-one) on agar medium supplemented with glucose and peptone. The approach made it possible to achieve respectively 96 and 67% decreases in effective concentrations of kathon and copper sulfate in the mixture.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0964-8305 1879-0208
DOI:	10.1016/j.ibiod.2005.02.001