Search Results - "Kobeissy, Firas"

AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study by El-Hachem, Nehme, Haibe-Kains, Benjamin, Khalil, Athar, Kobeissy, Firas H, Nemer, Georges

“…Computational docking and scoring techniques have revolutionized structural bioinformatics by providing unprecedented insights on key aspects of…”
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Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms by Slika, Hasan, Mansour, Hadi, Wehbe, Nadine, Nasser, Suzanne A., Iratni, Rabah, Nasrallah, Gheyath, Shaito, Abdullah, Ghaddar, Tarek, Kobeissy, Firas, Eid, Ali H.

“…Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and…”
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CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat by Krasnova, Irina N, Chiflikyan, Margarit, Justinova, Zuzana, McCoy, Michael T, Ladenheim, Bruce, Jayanthi, Subramaniam, Quintero, Cynthia, Brannock, Christie, Barnes, Chanel, Adair, Jordan E, Lehrmann, Elin, Kobeissy, Firas H, Gold, Mark S, Becker, Kevin G, Goldberg, Steven R, Cadet, Jean Lud

“…Abstract Neuroplastic changes in the dorsal striatum participate in the transition from casual to habitual drug use and might play a critical role in the…”
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Editorial: Revisiting mouse models of traumatic brain injuries: a focus on intracellular mechanisms by Omais, Saad, Kobeissy, Firas, Zibara, Kazem, Shaito, Abdullah

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MS‐based glycomics and glycoproteomics methods enabling isomeric characterization by Peng, Wenjing, Gutierrez Reyes, Cristian D., Gautam, Sakshi, Yu, Aiying, Cho, Byeong Gwan, Goli, Mona, Donohoo, Kaitlyn, Mondello, Stefania, Kobeissy, Firas, Mechref, Yehia

“…Glycosylation is one of the most significant and abundant posttranslational modifications in mammalian cells. It mediates a wide range of biofunctions,…”
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Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap by Simonato, Michele, Agoston, Denes V., Brooks-Kayal, Amy, Dulla, Chris, Fureman, Brandy, Henshall, David C., Pitkänen, Asla, Theodore, William H., Twyman, Roy E., Kobeissy, Firas H., Wang, Kevin K., Whittemore, Vicky, Wilcox, Karen S.

“…Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an identified genetic defect. Given that the precipitating…”
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Satureja khuzistanica Jamzad essential oil and pure carvacrol attenuate TBI-induced inflammation and apoptosis via NF-κB and caspase-3 regulation in the male rat brain by Abbasloo, Elham, Amiresmaili, Sedigheh, Shirazpour, Sara, Khaksari, Mohammad, Kobeissy, Firas, Thomas, Theresa Currier

“…Traumatic brain injury (TBI) causes progressive dysfunction that induces biochemical and metabolic changes that lead to cell death. Nevertheless, there is no…”
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Psychological distress experienced by physicians and nurses at a tertiary care center in Lebanon during the COVID-19 outbreak by Bizri, Maya, Kassir, Ghida, Tamim, Hani, Kobeissy, Firas, Hayek, Samer El

“…The COVID-19 outbreak has had a significant mental health toll on healthcare workers in Lebanon. We examined pandemic-related psychological distress among…”
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Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization by Yadikar, Hamad, Torres, Isabel, Aiello, Gabrielle, Kurup, Milin, Yang, Zhihui, Lin, Fan, Kobeissy, Firas, Yost, Richard, Wang, Kevin K

“…Tauopathies are a class of neurodegenerative disorders characterized by abnormal deposition of post-translationally modified tau protein in the human brain…”
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Glycoproteins Enrichment and LC-MS/MS Glycoproteomics in Central Nervous System Applications by Zhu, Rui, Song, Ehwang, Hussein, Ahmed, Kobeissy, Firas H, Mechref, Yehia

“…Proteins and glycoproteins play important biological roles in central nervous systems (CNS). Qualitative and quantitative evaluation of proteins and…”
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MS-based glycomics: An analytical tool to assess nervous system diseases by Peng, Wenjing, Kobeissy, Firas, Mondello, Stefania, Barsa, Chloe, Mechref, Yehia

“…Neurological diseases affect millions of peopleochemistryorldwide and are continuously increasing due to the globe’s aging population. Such diseases affect the…”
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Carvacrol decreases blood–brain barrier permeability post-diffuse traumatic brain injury in rats by Abbasloo, Elham, Khaksari, Mohammad, Sanjari, Mojgan, Kobeissy, Firas, Thomas, Theresa Currier

“…Previously, we showed that Satureja Khuzestanica Jamzad essential oil (SKEO) and its major component, carvacrol (CAR), 5-isopropyl-2-methylphenol, has…”
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Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury by Wang, Kevin K.W., Kobeissy, Firas H., Shakkour, Zaynab, Tyndall, J. Adrian

“…Traumatic brain injury (TBI) is a major cause of mortality and morbidity affecting all ages. It remains to be a diagnostic and therapeutic challenge, in which,…”
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A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption by Mona, Mahmoud, Abbasi, Zunnaira, Kobeissy, Firas, Chahbandar, Abdulrahman, Pileggi, Roberta

“…External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection,…”
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Therapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I:C)-stimulated macrophages by Rose, Mélanie, Duhamel, Marie, Aboulouard, Soulaimane, Kobeissy, Firas, Tierny, Dominique, Fournier, Isabelle, Rodet, Franck, Salzet, Michel

“…Macrophages plasticity is a key feature in cancer progression. Neoplastic cells can alter their immune functions and orient them into a pro-tumoral phenotype…”
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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase by AlFadly, Ehab D., Elzahhar, Perihan A., Tramarin, Anna, Elkazaz, Salwa, Shaltout, Hossam, Abu-Serie, Marwa M., Janockova, Jana, Soukup, Ondrej, Ghareeb, Doaa A., El-Yazbi, Ahmed F., Rafeh, Rim W., Bakkar, Nour-Mounira Z., Kobeissy, Firas, Iriepa, Isabel, Moraleda, Ignacio, Saudi, Manal N.S., Bartolini, Manuela, Belal, Ahmed S.F.

“…Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment…”
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Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions by Delcourt, Vivian, Franck, Julien, Quanico, Jusal, Gimeno, Jean-Pascal, Wisztorski, Maxence, Raffo-Romero, Antonella, Kobeissy, Firas, Roucou, Xavier, Salzet, Michel, Fournier, Isabelle

“…Tissue spatially-resolved proteomics was performed on 3 brain regions, leading to the characterization of 123 reference proteins. Moreover, 8 alternative…”
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The Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach by El-Baba, Chirine, Ayache, Zeinab, Goli, Mona, Hayar, Berthe, Kawtharani, Zeinab, Pisano, Claudio, Kobeissy, Firas, Mechref, Yehia, Darwiche, Nadine

“…Glioblastoma Multiforme (GBM) is the most aggressive form of malignant brain tumor. The median survival rate does not exceed two years, indicating an imminent…”
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Surfaceome Proteomic of Glioblastoma Revealed Potential Targets for Immunotherapy by Rose, Mélanie, Cardon, Tristan, Aboulouard, Soulaimane, Hajjaji, Nawale, Kobeissy, Firas, Duhamel, Marie, Fournier, Isabelle, Salzet, Michel

“…Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New…”
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Biofluid Proteomics and Biomarkers in Traumatic Brain Injury by Azar, Safa, Hasan, Anwarul, Younes, Richard, Najdi, Farah, Baki, Lama, Ghazale, Hussein, Kobeissy, Firas H, Zibara, Kazem, Mondello, Stefania

“…Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and…”
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