Search Results - "Kobbi, Lydia"
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An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb
Published in Proceedings of the National Academy of Sciences - PNAS (08-11-2016)“…The positive transcription elongation factor (P-TEFb) is required for the transcription of most genes by RNA polymerase II. Hexim proteins associated with 7SK…”
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Association of Mitochondrial Lysyl-tRNA Synthetase with HIV-1 GagPol Involves Catalytic Domain of the Synthetase and Transframe and Integrase Domains of Pol
Published in Journal of molecular biology (29-07-2011)“…Cytosolic and mitochondrial lysyl-tRNA synthetases (LysRS) are encoded by a single gene and can be distinguished only according to their very N-terminal…”
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Activation of Human Mitochondrial Lysyl-tRNA Synthetase upon Maturation of Its Premitochondrial Precursor
Published in Biochemistry (Easton) (31-01-2012)“…The cytoplasmic and mitochondrial species of human lysyl-tRNA synthetase are encoded by a single gene by means of alternative splicing of the KARS1 gene. The…”
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A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
Published in Retrovirology (01-07-2014)“…The positive transcription elongation factor b (P-TEFb) plays an essential role in activating HIV genome transcription. It is recruited to the HIV LTR promoter…”
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Association of human mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol does not require other viral proteins
Published in Biochimie open (01-06-2016)“…In human, the cytoplasmic (cLysRS) and mitochondrial (mLysRS) species of lysyl-tRNA synthetase are encoded by a single gene. Following HIV-1 infection, mLysRS…”
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