Search Results - "Kobayashi, Yoshiomi"

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice by Nori, Satoshi, Okada, Yohei, Yasuda, Akimasa, Tsuji, Osahiko, Takahashi, Yuichiro, Kobayashi, Yoshiomi, Fujiyoshi, Kanehiro, Koike, Masato, Uchiyama, Yasuo, Ikeda, Eiji, Toyama, Yoshiaki, Yamanaka, Shinya, Nakamura, Masaya, Okano, Hideyuki

“…Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not entail ethical concerns, may become a preferred cell source for…”
Get full text

Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity by Kobayashi, Yoshiomi, Okada, Yohei, Itakura, Go, Iwai, Hiroki, Nishimura, Soraya, Yasuda, Akimasa, Nori, Satoshi, Hikishima, Keigo, Konomi, Tsunehiko, Fujiyoshi, Kanehiro, Tsuji, Osahiko, Toyama, Yoshiaki, Yamanaka, Shinya, Nakamura, Masaya, Okano, Hideyuki

“…Murine and human iPSC-NS/PCs (induced pluripotent stem cell-derived neural stem/progenitor cells) promote functional recovery following transplantation into…”
Get full text

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS by Bravo-Hernandez, Mariana, Tadokoro, Takahiro, Navarro, Michael R., Platoshyn, Oleksandr, Kobayashi, Yoshiomi, Marsala, Silvia, Miyanohara, Atsushi, Juhas, Stefan, Juhasova, Jana, Skalnikova, Helena, Tomori, Zoltan, Vanicky, Ivo, Studenovska, Hana, Proks, Vladimir, Chen, PeiXi, Govea-Perez, Noe, Ditsworth, Dara, Ciacci, Joseph D., Gao, Shang, Zhu, Wenlian, Ahrens, Eric T., Driscoll, Shawn P., Glenn, Thomas D., McAlonis-Downes, Melissa, Da Cruz, Sandrine, Pfaff, Samuel L., Kaspar, Brian K., Cleveland, Don W., Marsala, Martin

“…Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherited neurodegenerative disorders. In the present study we…”
Get full text

Surgical outcomes of anterior column reconstruction for spinal fractures caused by minor trauma-preoperative examination of the number of intervertebral bone bridges is key to obtaining good bone fusion by Furukawa, Mitsuru, Fujiyoshi, Kanehiro, Kajikawa, Keita, Kobayashi, Yoshiomi, Konomi, Tsunehiko, Yato, Yoshiyuki

“…To achieve good bone fusion in anterior column reconstruction for vertebral fractures, not only bone mineral density (BMD) and bone metabolism markers but also…”
Get full text

Cortical bone trajectory and traditional trajectory—a radiological evaluation of screw-bone contact by Kojima, Kota, Asamoto, Shunji, Kobayashi, Yoshiomi, Ishikawa, Masayuki, Fukui, Yasuyuki

“…Background Cortical bone trajectory (CBT), a relatively new technique for pedicle screw insertion in the lumbar spine, is believed to have equivalent pullout…”
Get full text

Spontaneous correction of sagittal spinopelvic malalignment after decompression surgery without corrective fusion procedure for lumbar spinal stenosis and its impact on clinical outcomes: A systematic review by Ogura, Yoji, Kobayashi, Yoshiomi, Shinozaki, Yoshio, Ogawa, Jun

“…The impact of a positive sagittal vertical axis (SVA) on the surgical outcome for lumbar spinal stenosis (LSS) remains unclear, because sagittal imbalance in…”
Get full text

Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury by Nishimura, Soraya, Yasuda, Akimasa, Iwai, Hiroki, Takano, Morito, Kobayashi, Yoshiomi, Nori, Satoshi, Tsuji, Osahiko, Fujiyoshi, Kanehiro, Ebise, Hayao, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

“…The transplantation of neural stem/progenitor cells (NS/PCs) at the sub-acute phase of spinal cord injury, but not at the chronic phase, can promote functional…”
Get full text

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury by Kawabata, Soya, Takano, Morito, Numasawa-Kuroiwa, Yuko, Itakura, Go, Kobayashi, Yoshiomi, Nishiyama, Yuichiro, Sugai, Keiko, Nishimura, Soraya, Iwai, Hiroki, Isoda, Miho, Shibata, Shinsuke, Kohyama, Jun, Iwanami, Akio, Toyama, Yoshiaki, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki

“…Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into…”
Get full text

Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition by Nori, Satoshi, Okada, Yohei, Nishimura, Soraya, Sasaki, Takashi, Itakura, Go, Kobayashi, Yoshiomi, Renault-Mihara, Francois, Shimizu, Atsushi, Koya, Ikuko, Yoshida, Rei, Kudoh, Jun, Koike, Masato, Uchiyama, Yasuo, Ikeda, Eiji, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

“…Previously, we described the safety and therapeutic potential of neurospheres (NSs) derived from a human induced pluripotent stem cell (iPSC) clone, 201B7, in…”
Get full text

Minimum clinically important difference of major patient-reported outcome measures in patients undergoing decompression surgery for lumbar spinal stenosis by Ogura, Yoji, Ogura, Koichi, Kobayashi, Yoshiomi, Kitagawa, Takahiro, Yonezawa, Yoshiro, Takahashi, Yoshiyuki, Yoshida, Kodai, Yasuda, Akimasa, Shinozaki, Yoshio, Ogawa, Jun

“…•MCIDs are disease- and procedure-specific.•No MCIDs of major PROMs specific to LSS undergoing decompression were reported.•MCIDs of the NRS, RMDQ, and SF-8…”
Get full text

Impact of decompression surgery without fusion for lumbar spinal stenosis on sagittal spinopelvic alignment: minimum 2-year follow-up by Ogura, Yoji, Shinozaki, Yoshio, Kobayashi, Yoshiomi, Kitagawa, Takahiro, Yonezawa, Yoshiro, Takahashi, Yohei, Yoshida, Kodai, Yasuda, Akimasa, Ogawa, Jun

“…The importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward to relieve their…”
Get full text

Effects of Bone Cross-Link Bridging on Fracture Mechanism and Surgical Outcomes in Elderly Patients with Spine Fractures by Furukawa, Mitsuru, Fujiyoshi, Kanehiro, Okubo, Toshiki, Yanai, Yoshihide, Matsubayashi, Kohei, Kato, Takashi, Kobayashi, Yoshiomi, Konomi, Tsunehiko, Yato, Yoshiyuki

“…This study adopted a cross-sectional study design. This study was designed to investigate the effects of bone cross-link bridging on fracture mechanism and…”
Get full text

Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation by Itakura, Go, Kobayashi, Yoshiomi, Nishimura, Soraya, Iwai, Hiroki, Takano, Morito, Iwanami, Akio, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

“…Our previous work reported functional recovery after transplantation of mouse and human induced pluripotent stem cell-derived neural stem/progenitor cells…”
Get full text

Undisplaced femoral neck fractures need a closed reduction before internal fixation by Yamamoto, Tatsuya, Kobayashi, Yoshiomi, Nonomiya, Hiroaki

“…Introduction Undisplaced femoral neck fractures (UFNF) are generally treated with in situ internal fixation, and few studies have addressed the impact of…”
Get full text

Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review by Tashiro, Syoichi, Tsuji, Osahiko, Shinozaki, Munehisa, Shibata, Takahiro, Yoshida, Takashi, Tomioka, Yohei, Unai, Kei, Kondo, Takahiro, Itakura, Go, Kobayashi, Yoshiomi, Yasuda, Akimasa, Nori, Satoshi, Fujiyoshi, Kanehiro, Nagoshi, Narihito, Kawakami, Michiyuki, Uemura, Osamu, Yamada, Shin, Tsuji, Tetsuya, Okano, Hideyuki, Nakamura, Masaya

“…Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is…”
Get full text

Impact of leg numbness on patient satisfaction following decompression surgery for lumbar spinal stenosis by Ogura, Yoji, Takahashi, Yoshiyuki, Kitagawa, Takahiro, Yonezawa, Yoshiro, Yoshida, Kodai, Takeda, Kazuki, Kobayashi, Yoshiomi, Takahashi, Yohei, Alhammoud, Abduljabbar, Yasuda, Akimasa, Shinozaki, Yoshio, Ogawa, Jun

“…•Impact of postoperative residual numbness on patient satisfaction has not been well studied.•Residual numbness had a greater impact than leg/back pain on…”
Get full text

Baseline severity of myelopathy predicts neurological outcomes after posterior decompression surgery for cervical spondylotic myelopathy: a retrospective study by Nori, Satoshi, Nagoshi, Narihito, Kono, Hitoshi, Kobayashi, Yoshiomi, Isogai, Norihiro, Ninomiya, Ken, Tsuji, Takashi, Horiuchi, Yosuke, Takemura, Ryo, Kimura, Ryusei, Tsuji, Osahiko, Suzuki, Satoshi, Okada, Eijiro, Yagi, Mitsuru, Nakamura, Masaya, Matsumoto, Morio, Watanabe, Kota, Ishii, Ken, Yamane, Junichi

“…Study design Retrospective multicenter study. Objectives To identify the usefulness of the baseline severity of myelopathy for predicting surgical outcomes for…”
Get full text

Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates by Iwai, Hiroki, Shimada, Hiroko, Nishimura, Soraya, Kobayashi, Yoshiomi, Itakura, Go, Hori, Keiko, Hikishima, Keigo, Ebise, Hayao, Negishi, Naoko, Shibata, Shinsuke, Habu, Sonoko, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

“…Previous studies have demonstrated that neural stem/progenitor cells (NS/PCs) promote functional recovery in rodent animal models of spinal cord injury (SCI)…”
Get full text

Changes in sagittal alignment after surgical excision of thoracic spinal cord tumors in adults by Kobayashi, Yoshiomi, Kawabata, Soya, Nishiyama, Yuichiro, Tsuji, Osahiko, Okada, Eijiro, Fujita, Nobuyuki, Yagi, Mitsuru, Watanabe, Kota, Matsumoto, Morio, Nakamura, Masaya, Nagoshi, Narihito

“…Study design Retrospective chart audit. Objectives This study investigated changes in sagittal alignment in adults after excision of thoracic spinal cord…”
Get full text

Factors Influencing Patient Satisfaction After Decompression Surgery Without Fusion for Lumbar Spinal Stenosis by Ogura, Yoji, Kobayashi, Yoshiomi, Shinozaki, Yoshio, Kitagawa, Takahiro, Yonezawa, Yoshiro, Takahashi, Yoshiyuki, Yoshida, Kodai, Yasuda, Akimasa, Ogawa, Jun

“…Study Design: Retrospective cohort study. Objectives: Decompression without fusion is a standard surgical treatment for lumbar spinal stenosis (LSS) with…”
Get full text