Search Results - "Kobayashi, Takehiko"

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast by Kobayashi, Takehiko

“…The genes encoding ribosomal RNA (rRNA) are the most abundant genes in the eukaryotic genome. They reside in tandem repetitive clusters, in some cases totaling…”
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Ribosomal RNA gene repeats, their stability and cellular senescence by KOBAYASHI, Takehiko

“…The ribosomal RNA gene (rDNA) repeats form a historically well-researched region in the chromosome. Their highly repetitive structure can be identified easily…”
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new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrity by Kobayashi, Takehiko

“…The nucleolus is a region of the nucleus with high protein density and it acts as a ribosome factory. The nucleolus contains a distinct region of the genome,…”
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RNA Polymerase I Activators Count and Adjust Ribosomal RNA Gene Copy Number by Iida, Tetsushi, Kobayashi, Takehiko

“…Ribosome is the most abundant RNA-protein complex in a cell, and many copies of the ribosomal RNA gene (rDNA) have to be maintained. However, arrays of…”
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The human ribosomal DNA array is composed of highly homogenized tandem clusters by Hori, Yutaro, Shimamoto, Akira, Kobayashi, Takehiko

“…The structure of the human ribosomal DNA (rDNA) cluster has traditionally been hard to analyze owing to its highly repetitive nature. However, the recent…”
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Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity by Ide, Satoru, Miyazaki, Takaaki, Maki, Hisaji, Kobayashi, Takehiko

“…The ribosomal RNA (rDNA) gene repeats are essential housekeeping genes found in all organisms. A gene amplification system maintains large cluster(s) of…”
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Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage by Horigome, Chihiro, Unozawa, Eri, Ooki, Takamasa, Kobayashi, Takehiko

“…The ribosomal RNA genes (rDNA) comprise a highly repetitive gene cluster. The copy number of genes at this locus can readily change and is therefore one of the…”
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Establishment of an “in saccharo” experimental system by Iida, Tetsushi, Kobayashi, Takehiko

“…Many proteins form complexes that function in reaction pathways. Therefore, to understand protein function, it is necessary to reconstitute complexes and…”
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Gel Electrophoresis Analysis of rDNA Instability in Saccharomyces cerevisiae by Sasaki, Mariko, Kobayashi, Takehiko

“…The ribosomal RNA (rDNA) sequence is the most abundant repetitive element in the budding yeast genome and forms a tandem cluster of ~100-200 copies. Cells…”
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Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks by Sasaki, Mariko, Kobayashi, Takehiko

“…Organisms have evolved elaborate mechanisms that maintain genome stability. Deficiencies in these mechanisms result in changes to the nucleotide sequence as…”
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Ribosomal DNA stability is supported by many ‘buffer genes’—introduction to the Yeast rDNA Stability Database by Kobayashi, Takehiko, Sasaki, Mariko

“…Abstract The ribosomal RNA gene (rDNA) is the most abundant gene in yeast and other eukaryotic organisms. Due to its heavy transcription, repetitive structure…”
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RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster by Yanagi, Shuichi, Iida, Tetsushi, Kobayashi, Takehiko

“…Genome instability causes cellular senescence in many organisms. The rRNA gene cluster (rDNA) is one of the most unstable regions in the genome and this…”
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Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters by Yokoyama, Masaaki, Sasaki, Mariko, Kobayashi, Takehiko

“…Genome instability can drive aging in many organisms. The ribosomal RNA gene (rDNA) cluster is one of the most unstable regions in the genome and the stability…”
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More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance by Saka, Kimiko, Takahashi, Akihiro, Sasaki, Mariko, Kobayashi, Takehiko

“…Genome instability triggers cellular senescence and is a common cause of cancer. The ribosomal RNA genes (rDNA), due to their repetitive structure, form a…”
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Cutaneous Leukocytoclastic Vasculitis Associated with Pulmonary Tuberculosis and an Anti-tuberculosis Drug by Tanaka, Yuya, Kobayashi, Takehiko, Shimizu, Shigeki, Kurahara, Yu

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Evaluation of repair activity by quantification of ribonucleotides in the genome by Iida, Tetsushi, Iida, Naoko, Sese, Jun, Kobayashi, Takehiko

“…Ribonucleotides incorporated in the genome are a source of endogenous DNA damage and also serve as signals for repair. Although recent advances of…”
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Rejuvenation of ribosomal RNA gene repeats at the nuclear pore by Horigome, Chihiro, Kobayashi, Takehiko

“…The ribosomal RNA genes (rDNA) exist as tandem repeats in eukaryotes and are, therefore, highly unstable. Each rDNA unit includes a replication fork barrier…”
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Changed life course upon defective replication of ribosomal RNA genes by Hattori, Mei, Horigome, Chihiro, Aspert, Théo, Charvin, Gilles, Kobayashi, Takehiko

“…Genome instability is a major cause of aging. In the budding yeast Saccharomyces cerevisiae, instability of the ribosomal RNA gene repeat (rDNA) is known to…”
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Defects in the NuA4 acetyltransferase complex increase stability of the ribosomal RNA gene and extend replicative lifespan by Wakatsuki, Tsuyoshi, Sasaki, Mariko, Kobayashi, Takehiko

“…Genome instability is a cause of cellular senescence. The ribosomal RNA gene repeat (rDNA) is one of the most unstable regions in the genome and its…”
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Mycobacterium avium Pleurisy with Bronchopleural Fistula Resulting in Rapidly Progressive Respiratory Failure Diagnosed by Transbronchial Autopsy by Osaki, Megumu, Kobayashi, Takehiko, Yoshida, Shiomi, Shimizu, Shigeki, Tsuyuguchi, Kazunari

“…Nontuberculous mycobacterial lung disease usually manifests as a chronic pulmonary infection. We herein report a fatal case of Mycobacterium avium pleurisy in…”
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