Search Results - "Kobayashi, Michiyoshi"

Safety, Tolerability, and Pharmacokinetic Profile of the Novel Translocator Protein 18 kDa Antagonist ONO-2952 in Healthy Volunteers by Suto, Fumitaka, MSc, Wood, Andrew T., PhD, Kobayashi, Michiyoshi, MSc, Komaba, Junji, PhD, Duffy, Kevin, PhD, Bruce, Mark, PhD

“…Abstract Purpose To investigate safety, tolerability, and pharmacokinetic properties of single and multiple doses of novel translocator protein 18 kDa…”
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Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth by Amano, Hideki, Hayashi, Izumi, Endo, Hirahito, Kitasato, Hidero, Yamashina, Shohei, Maruyama, Takayuki, Kobayashi, Michiyoshi, Satoh, Kazutoyo, Narita, Masami, Sugimoto, Yukihiko, Murata, Takahiko, Yoshimura, Hirokuni, Narumiya, Shuh, Majima, Masataka

“…Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism of…”
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Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice by Kitamura, Tomohiro, Itoh, Masaki, Noda, Tetsuo, Tani, Kousuke, Kobayashi, Michiyoshi, Maruyama, Takayuki, Kobayashi, Kaoru, Ohuchida, Shuichi, Sugimura, Takashi, Wakabayashi, Keiji

“…Previous studies have shown that prostaglandin E2 (PGE2) is involved in intestinal carcinogenesis through its binding to the PGE2 receptor subtypes EP1 and EP4…”
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Denitrification, a Novel Type of Respiratory Metabolism in Fungal Mitochondrion by Kobayashi, Michiyoshi, Matsuo, Yushi, Takimoto, Akiko, Suzuki, Sawako, Maruo, Fumiaki, Shoun, Hirofumi

“…Subcellular localization and coupling to ATP synthesis were investigated with respect to the denitrifying systems of two fungi, Fusarium oxysporum and…”
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The copper-containing dissimilatory nitrite reductase involved in the denitrifying system of the fungus Fusarium oxysporum by Kobayashi, M. (University of Tsukuba, Ibaraki, Japan.), Shoun, H

“…A copper-containing nitrite reductase (Cu-NiR) was purified to homogeneity from the denitrifying fungus Fusarium oxysporum. The enzyme seemed to consist of two…”
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Combined effects of prostaglandin E receptor subtype EP 1 and subtype EP 4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice by Kitamura, Tomohiro, Itoh, Masaki, Noda, Tetsuo, Tani, Kousuke, Kobayashi, Michiyoshi, Maruyama, Takayuki, Kobayashi, Kaoru, Ohuchida, Shuichi, Sugimura, Takashi, Wakabayashi, Keiji

“…Previous studies have shown that prostaglandin E 2 (PGE 2 ) is involved in intestinal carcinogenesis through its binding to the PGE 2 receptor subtypes EP 1…”
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Brain translocator protein occupancy by ONO‐2952 in healthy adults: A Phase 1 PET study using [11C]PBR28 by Frankle, W. Gordon, Narendran, Rajesh, Wood, Andrew T., Suto, Fumitaka, Himes, Michael L., Kobayashi, Michiyoshi, Ohno, Tomoya, Yamauchi, Akinori, Mitsui, Katsukuni, Duffy, Kevin, Bruce, Mark

“…ONO‐2952, a novel antagonist of translocator protein 18 kDa (TSPO), binds with high affinity to TSPO in rat brain and human tumor cell line membrane…”
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Involvement of prostaglandin E receptor subtype EP4 in colon carcinogenesis by MUTOH, Michihiro, WATANABE, Kouji, OHUCHIDA, Shuichi, SUGIMOTO, Yukihiko, NARUMIYA, Shuh, SUGIMURA, Takashi, WAKABAYASHI, Keiji, KITAMURA, Tomohiro, SHOJI, Yutaka, TAKAHASHI, Mami, KAWAMORI, Toshihiko, TANI, Kousuke, KOBAYASHI, Michiyoshi, MARUYAMA, Takayuki, KOBAYASHI, Kaoru

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Effects of N-alkyl and ammonium groups on the hydrolytic cleavage of DNA with a Cu(II)TACH (1,3,5-triaminocyclohexane) complex. Speciation, kinetic, and DNA-binding studies for reaction mechanism by Kobayashi, Tohru, Tobita, Satoko, Kobayashi, Michiyoshi, Imajyo, Takuya, Chikira, Makoto, Yashiro, Morio, Fujii, Yuki

“…cis, cis-1,3,5-Triaminocyclohexane ( c-TACH), its N-alkyl-derivatives (alkyl = methyl, ethyl), and trans, cis-1,3,5-triaminocyclohexane ( t-TACH) were…”
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Discovery of new chemical leads for selective EP1 receptor antagonists by Naganawa, Atsushi, Saito, Tetsuji, Nagao, Yuuki, Egashira, Hiromu, Iwahashi, Maki, Kambe, Tohru, Koketsu, Masatoshi, Yamamoto, Hiroshi, Kobayashi, Michiyoshi, Maruyama, Takayuki, Ohuchida, Shuichi, Nakai, Hisao, Kondo, Kigen, Toda, Masaaki

“…Discovery process of new selective EP1 receptor antagonists 21– 23 starting from 1. A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids…”
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Host Prostaglandin E sub(2)-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth by Amano, Hideki, Hayashi, Izumi, Endo, Hirahito, Kitasato, Hidero, Yamashina, Shohei, Maruyama, Takayuki, Kobayashi, Michiyoshi, Satoh, Kazutoyo, Narita, Masami, Sugimoto, Yukihiko, Murata, Takahiko, Yoshimura, Hirokuni, Narumiya, Shuh, Majima, Masataka

“…Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism of…”
Get full text

Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth by Amano, Hideki, Hayashi, Izumi, Endo, Hirahito, Kitasato, Hidero, Yamashina, Shohei, Maruyama, Takayuki, Kobayashi, Michiyoshi, Satoh, Kazutoyo, Narita, Masami, Sugimoto, Yukihiko, Murata, Takahiko, Yoshimura, Hirokuni, Narumiya, Shuh, Majima, Masataka

“…Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism of…”
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Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis by Mutoh, Michihiro, Watanabe, Kouji, Kitamura, Tomohiro, Shoji, Yutaka, Takahashi, Mami, Kawamori, Toshihiko, Tani, Kousuke, Kobayashi, Michiyoshi, Maruyama, Takayuki, Kobayashi, Kaoru, Ohuchida, Shuichi, Sugimoto, Yukihiko, Narumiya, Shuh, Sugimura, Takashi, Wakabayashi, Keiji

“…Accumulating evidence indicates that overproduction of prostanoids attributable to overexpression of cyclooxygenase-2 (COX-2) plays an important role in colon…”
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Novel two types of orally active EP1 receptor antagonists by Maruyama, Takayuki, Koketsu, Masatoshi, Yamamoto, Hiroshi, Kobayashi, Michiyoshi, Sakata, Kiyoto, Yoshida, Hideyuki, Furukawa, Kenji, Ohuchida, Shuichi, Kondo, Kigen

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Novel four selective agonists for prostaglandin E receptor subtypes by Yamamoto, Hiroshi, Maruyama, Takayuki, Sakata, Kiyoto, Koketsu, Masatoshi, Kobayashi, Michiyoshi, Yoshida, Hideyuki, Seki, Akiteru, Tani, Kousuke, Maruyama, Toru, Kondo, Kigen, Ohuchida, Shuichi

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