Search Results - "Kobashi Kenta"

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma by Nakagaki, Takafumi, Tamura, Miyuki, Kobashi, Kenta, Omori, Akina, Koyama, Ryota, Idogawa, Masashi, Ogi, Kazuhiro, Hiratsuka, Hiroyoshi, Tokino, Takashi, Sasaki, Yasushi

“…Somatic mutation analysis is a standard of practice for human cancers to identify therapeutic sensitization and resistance mutations. We performed a multigene…”
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Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing by Nakagaki, Takafumi, Tamura, Miyuki, Kobashi, Kenta, Koyama, Ryota, Fukushima, Hisayo, Ohashi, Tomoko, Idogawa, Masashi, Ogi, Kazuhiro, Hiratsuka, Hiroyoshi, Tokino, Takashi, Sasaki, Yasushi

“…Somatic mutation analysis is a standard practice in the study of human cancers to identify mutations that cause therapeutic sensitization and resistance. We…”
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Intrahepatic cholangiocarcinoma with a liver abscess due to hepatic actinomycosis by Masuda, Tomoya, Kobashi, Kenta, Sugimoto, Ryoma, Ishii, Hiroshi, Tsunemitsu, Kensuke

“…Background Liver tumors with liver abscesses are unusual and rarely reported. In particular, studies of intrahepatic cholangiocarcinoma with liver abscesses…”
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CRKL oncogene is downregulated by p53 through miR‐200s by Tamura, Miyuki, Sasaki, Yasushi, Kobashi, Kenta, Takeda, Kousuke, Nakagaki, Takafumi, Idogawa, Masashi, Tokino, Takashi

“…Tumor suppressive miRNAs that target oncogenes are frequently downregulated in cancers, and this downregulation leads to oncogene pathway activation. Thus,…”
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Electronic Spectra of Graphene in Far- and Deep-Ultraviolet Region: Attenuated Total Reflection Spectroscopy and Quantum Chemical Calculation Study by Beć, Krzysztof B, Morisawa, Yusuke, Kobashi, Kenta, Grabska, Justyna, Tanabe, Ichiro, Ozaki, Yukihiro

“…We measured the electronic spectra of graphene nanostructures (flakes and platelets) extending into the far-ultraviolet (FUV) region by attenuated total…”
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Durvalumab after chemoradiotherapy in non‐small cell lung cancer with EGFR mutation: A real‐world study (HOT2101) by Tsuji, Kosuke, Mizugaki, Hidenori, Yokoo, Keiki, Kobayashi, Maki, Kawashima, Yosuke, Kimura, Nozomu, Yokouchi, Hiroshi, Kikuchi, Hajime, Sumi, Toshiyuki, Kawai, Yasutaka, Kobashi, Kenta, Morita, Ryo, Ito, Kenichiro, Kitamura, Yasuo, Minemura, Hiroyuki, Nakamura, Keiichi, Aso, Mari, Honjo, Osamu, Tanaka, Hisashi, Takashina, Taichi, Tsurumi, Kyoji, Sugisaka, Jun, Tsukita, Yoko, Konno, Satoshi, Oizumi, Satoshi

“…Durvalumab has been administered to patients with unresectable stage III non‐small cell lung cancer (NSCLC). However, it remains unclear whether durvalumab…”
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CR obtained by CPT-11 and CDDP combination-therapy in a small-cell lung-cancer patient through effective pharmaceutical care by Asagawa, Takashige, Ishii, Hiroshi, Kobashi, Kenta, Tsunemitsu, Kensuke, Itou, Mie, Ninomiya, Hisashi, Higaki, Rika, Miyazaki, Fumiko, Murakami, Michiyasu, Noguchi, Tadashi

“…We encountered a 64-year-old UGT1A1*28 heterotype patient who received CPT-11 and CDDP chemotherapy for Stage III A small-cell lung-cancer and developed grade…”
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Abstract 1222: p53 downregulates CRKL proto-oncogene protein through miR-200 family by Sasaki, Yasushi, Tamura, Miyuki, Kobashi, Kenta, Takeda, Kousuke, Nakagaki, Takafumi, Idogawa, Masashi, Tokino, Takashi

“…The downregulation of the miR-200 family has been involved in the progression and metastasis of human cancers. The miR-200 family includes two clusters:…”
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Abstract 3707: Semiconductor-based next-generation sequencing analysis of 409 cancer-related genes for mutations and copy-number variations in oral squamous cell carcinoma by Nakagaki, Takafumi, Sasaki, Yasushi, Idogawa, Masashi, Koyama, Ryota, Kobashi, Kenta, Tamura, Miyuki, Ohashi, Tomoko, Ogi, Kazuhiro, Hiratsuka, Hiroyoshi, Tokino, Takashi

“…Somatic mutation analysis is standard of practice for human cancers in order to identify therapeutic sensitizing and resistance mutations. To better understand…”
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Abstract 4905: Comprehensive genomic analyses of oral squamous cell carcinoma tissues by semiconductor-based next-generation sequencing by Nakagaki, Takafumi, Sasaki, Yasushi, Kobashi, Kenta, Takeda, Kousuke, Tamura, Miyuki, Ohashi, Tomoko, Ogi, Kazuhiro, Idogawa, Masashi, Hiratsuka, Hiroyoshi, Tokino, Takashi

“…Somatic mutation analysis is standard of practice for human cancers in order to identify therapeutic sensitizing and resistance mutations. We performed…”
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Clinical Value of Neopterin In Infectious Complications by Iwagaki Hiromi, Hizuta Akio, Kobashi Kenta, Isozaki Hiroshi, Takakura Norihisa, Tanaka Noriaki

“…Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation,…”
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Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells by Kohka, H, Nishibori, M, Iwagaki, H, Nakaya, N, Yoshino, T, Kobashi, K, Saeki, K, Tanaka, N, Akagi, T

“…Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human…”
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Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia by Urushihara, Naoto, Iwagaki, Hiromi, Yagi, Takahito, Kohka, Hideo, Kobashi, Kenta, Morimoto, Yoshinori, Yoshino, Tadashi, Tanimoto, Tadao, Kurimoto, Masashi, Tanaka, Noriaki

“…Background/Purpose: Interleukin-18 (IL-18)/interferon-γ-inducing factor (TGIF) is a novel proinflammatory cytokine that can induce interferon gamma (IFN-γ). In…”
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Down-regulation of IL-18 receptor in cancer patients: its clinical significance by Kobashi, K, Iwagaki, H, Yoshino, T, Morimoto, Y, Kohka, H, Kodama, M, Nishibori, M, Akagi, T, Tanaka, N

“…Interleukin-18 (IL-18) is a powerful inducer of interferon-gamma (IFN-gamma), a key immunoregulatory cytokine. Cellular immune responsiveness, as measured by…”
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Involvement of interleukin-18 (IL-18) in mixed lymphocyte reactions (MLR) by Kohka, H, Iwagaki, H, Yoshino, T, Kobashi, K, Urushihara, N, Yagi, T, Tanimoto, T, Kurimoto, M, Akagi, T, Tanaka, N

“…The in vitro mixed lymphocyte reaction (MLR) is a useful model to study alloresponsiveness to histocompatibility antigens. Secretion of different cytokine…”
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Spontaneous rupture of hepatocellular carcinoma of the caudate lobe by Nakao, A, Matsuda, T, Koguchi, K, Funabiki, S, Mori, T, Kobashi, K, Takakura, N, Isozaki, H, Tanaka, N

“…A rare case of ruptured hepatocellular carcinoma (HCC) of the caudate lobe is reported. A 67-year-old man came to the hospital with complaints of abdominal…”
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Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions by Kuinose, M, Iwagaki, H, Morimoto, Y, Kohka, H, Kobashi, K, Sadamori, H, Inagaki, M, Urushihara, N, Yagi, T, Tanaka, N

“…Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the…”
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Modulatory effect of a serine protease inhibitor on surgical stress: its clinical implications by Iwagaki, H, Yagi, T, Urushihara, N, Kobashi, K, Morimoto, Y, Isozaki, H, Takakura, N, Tanaka, N

“…The relationship between endogenous cytokine antagonists and surgical stress is poorly understood. Surgical stress induces immunosuppression, and the reversed…”
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Hydrocortisone sodium succinate suppressed production of interleukin-10 by human peripheral blood mononuclear cells: clinical significance by Kohka, H, Iwagaki, H, Yoshino, T, Kobashi, K, Saito, S, Isozaki, H, Takakura, N, Tanaka, N

“…Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases,…”
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Circulating levels of soluble CD30 and other markers in colorectal cancer patients by Iwagaki, H, Hizuta, A, Kohka, H, Kobashi, K, Nitta, Y, Isozaki, H, Takakura, N, Tanaka, N

“…In a search for new biologic serum tumor markers with prognostic value we evaluated the soluble form of the CD30 (sCD30), a marker of cells producing T helper…”
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