Search Results - "Koběrská, Markéta"
-
1
Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities
Published in Journal of medicinal chemistry (22-08-2024)“…Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their optimization for…”
Get full text
Journal Article -
2
Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis
Published in PloS one (27-12-2013)“…Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less…”
Get full text
Journal Article -
3
High-throughput quantification of lincomycin traces in fermentation broth of genetically modified Streptomyces spp. Comparison of ultra-performance liquid chromatography and high-performance liquid chromatography with UV detection
Published in Journal of chromatography (19-01-2007)“…A new separation and quantification method using ultra-performance liquid chromatography (UPLC) with UV detection was developed for detection of lincomycin…”
Get full text
Journal Article -
4
Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis
Published in mBio (26-10-2021)“…In natural environments, antibiotics are important means of interspecies competition. At subinhibitory concentrations, they act as cues or signals inducing…”
Get full text
Journal Article -
5
Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism
Published in PloS one (05-03-2015)“…In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective…”
Get full text
Journal Article -
6
R/G Value-A Numeric Index of Individual Periodontal Health and Oral Microbiome Dynamics
Published in Frontiers in cellular and infection microbiology (10-03-2021)“…The dysbiosis of oral microbiome (OM) precedes the clinical signs of periodontal disease. Its simple measure thus could indicate individuals at risk of…”
Get full text
Journal Article -
7
High-throughput quantification of lincomycin traces in fermentation broth of genetically modified Streptomyces spp
Published in Journal of Chromatography A (2007)“…A new separation and quantification method using ultra-performance liquid chromatography (UPLC) with UV detection was developed for detection of lincomycin…”
Get full text
Journal Article -
8
Ribosome-Mediated Attenuation of vga (A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants
Published in Antimicrobial agents and chemotherapy (20-10-2020)“…Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LS P) by displacing antibiotics from the…”
Get full text
Journal Article -
9
-
10
Sequence analysis of porothramycin biosynthetic gene cluster
Published in Folia microbiologica (01-11-2014)“…The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces…”
Get full text
Journal Article