Search Results - "Koay, Tsin Shue"

ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma by Wu, Chiao-En, Koay, Tsin Shue, Esfandiari, Arman, Ho, Yi-Hsuan, Lovat, Penny, Lunec, John

“…MAPK and p14 ⁻MDM2⁻p53 pathways are critical in cutaneous melanomas. Here, synergistic combination of the MEK inhibitor, trametinib, with MDM2 inhibitors,…”
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TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response by Wu, Chiao-En, Koay, Tsin Shue, Ho, Yi-Hsuan, Lovat, Penny, Lunec, John

“…Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with…”
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Abstract 3034: TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response by Wu, Chiao-En, Koay, Tsin Shue, Ho, Yi-Hsuan, Lovat, Penny, Lunec, John

“…Abstract Emergence of resistance to molecular targeted therapy constitutes a potential limitation to clinical benefits in cancer treatment. Cross-resistance…”
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THU-320-YI The pan-cyclophilin inhibitor rencofilstat exhibits therapeutic anti-fibrotic effects in human relevant models of alcohol-related liver disease via extracellular matrix remodelling by Rastovic, Una, Campinoti, Sara, Wei, Lai, Almeida, Bruna, Bozzano, Sergio, Amiri, Ramin, Harris, Nicola, Ajayi, Omolola, Koay, Tsin Shue, Kerins, Caoimhe, Kenny, Fiona, Zamalloa, Ane, Adofina, Lissette, Miquel, Rosa, Zen, Yoh, Srinivasan, Parthi, Menon, Krishna, Heaton, Nigel, Luni, Camilla, Gentleman, Eileen, Shaw, Tanya, Ure, Daren, Chokshi, Shilpa, Urbani, Luca, Palma, Elena

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Cyclophilin inhibitor CRV431 as a potential therapy for alcohol-related liver disease by Palma, Elena, Campinoti, Sara, Rastovic, Una, Harris, Nicola, Koay, Tsin Shue, Ajayi, Lola, Almeida, Bruna, Phillips, Sandra, Ure, Daren, Preziosi, Melissa, Yumol, Marjorie, Miquel, Rosa, Zen, Yoh, Prachalias, Andreas, Menon, Krishna, Heaton, Nigel, Urbani, Luca, Chokshi, Shilpa

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