Search Results - "Koay, Melissa S."

Assembling Enzymatic Cascade Pathways inside Virus-Based Nanocages Using Dual-Tasking Nucleic Acid Tags by Brasch, Melanie, Putri, Rindia M, de Ruiter, Mark V, Luque, Daniel, Koay, Melissa. S. T, Castón, José R, Cornelissen, Jeroen J. L. M

“…The packaging of proteins into discrete compartments is an essential feature for cellular efficiency. Inspired by Nature, we harness virus-like assemblies as…”
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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis by Vinkenborg, Jan L, Nicolson, Tamara J, Bellomo, Elisa A, Koay, Melissa S, Rutter, Guy A, Merkx, Maarten

“…A series of genetically encoded fluorescent sensors for intracellular Zn 2+ with binding affinities spanning the picomolar and nanomolar ranges show that…”
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Structural Characterization of Native and Modified Encapsulins as Nanoplatforms for in Vitro Catalysis and Cellular Uptake by Putri, Rindia M, Allende-Ballestero, Carolina, Luque, Daniel, Klem, Robin, Rousou, Katerina-Asteria, Liu, Aijie, Traulsen, Christoph H.-H, Rurup, W. Frederik, Koay, Melissa S. T, Castón, José R, Cornelissen, Jeroen J. L. M

“…Recent years have witnessed the emergence of bacterial semiorganelle encapsulins as promising platforms for bio-nanotechnology. To advance the development of…”
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Self-Sorting of Foreign Proteins in a Bacterial Nanocompartment by Rurup, W. Frederik, Snijder, Joost, Koay, Melissa S. T, Heck, Albert J. R, Cornelissen, Jeroen J. L. M

“…Nature uses bottom-up approaches for the controlled assembly of highly ordered hierarchical structures with defined functionality, such as organelles,…”
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Assembly and Mechanical Properties of the Cargo-Free and Cargo-Loaded Bacterial Nanocompartment Encapsulin by Snijder, Joost, Kononova, Olga, Barbu, Ioana M, Uetrecht, Charlotte, Rurup, W. Frederik, Burnley, Rebecca J, Koay, Melissa S. T, Cornelissen, Jeroen J. L. M, Roos, Wouter H, Barsegov, Valeri, Wuite, Gijs J. L, Heck, Albert J. R

“…Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead, they have various protein-based organelles. These include…”
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Predicting the Loading of Virus-Like Particles with Fluorescent Proteins by Rurup, W. Frederik, Verbij, Fabian, Koay, Melissa S. T, Blum, Christian, Subramaniam, Vinod, Cornelissen, Jeroen J. L. M

“…The virus-like particle (VLP) of the Cowpea Chlorotic Mottle Virus (CCMV) has often been used to encapsulate foreign cargo. Here we show two different rational…”
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Generation-Dependent Templated Self-Assembly of Biohybrid Protein Nanoparticles around Photosensitizer Dendrimers by Setaro, Francesca, Brasch, Melanie, Hahn, Uwe, Koay, Melissa S. T, Cornelissen, Jeroen J. L. M, de la Escosura, Andrés, Torres, Tomás

“…In this article, we show the great potential of dendrimers for driving the self-assembly of biohybrid protein nanoparticles. Dendrimers are periodically…”
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Role of electrostatics in the assembly pathway of a single-stranded RNA virus by Garmann, Rees F, Comas-Garcia, Mauricio, Koay, Melissa S T, Cornelissen, Jeroen J L M, Knobler, Charles M, Gelbart, William M

“…We have recently discovered (R. D. Cadena-Nava et al., J. Virol. 86:3318-3326, 2012, doi:10.1128/JVI.06566-11) that the in vitro packaging of RNA by the capsid…”
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Photoprogramming Allostery in Human Serum Albumin by Putri, Rindia M, Zulfikri, Habiburrahman, Fredy, Jean Wilfried, Juan, Alberto, Tananchayakul, Pichayut, Cornelissen, Jeroen J. L. M, Koay, Melissa S. T, Filippi, Claudia, Katsonis, Nathalie

“…Developing strategies to interfere with allosteric interactions in proteins not only promises to deepen our understanding of vital cellular processes but also…”
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Chemotherapy pro-drug activation by biocatalytic virus-like nanoparticles containing cytochrome P450 by Sánchez-Sánchez, Lorena, Cadena-Nava, Rubén D., Palomares, Laura A., Ruiz-Garcia, Jaime, Koay, Melissa S.T., Cornelissen, Jeroen J.M.T., Vazquez-Duhalt, Rafael

“…•A bacterial CYP has been encapsulated inside virus-like nanoparticles (VLPs).•CYP-VLPs are able to transform chemotherapy pro-drugs tamoxifen and…”
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Tuning the metal binding site specificity of a fluorescent sensor protein: from copper to zinc and back by Koay, Melissa S, Janssen, Brian M G, Merkx, Maarten

“…We previously reported the development of high affinity Zn(2+) FRET sensors based on the Zn(2+)-mediated interaction between the CXXC motifs present in the…”
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Labelling Bacterial Nanocages with Photo-switchable Fluorophores by Putri, Rindia M., Fredy, Jean Wilfried, Cornelissen, Jeroen J. L. M., Koay, Melissa S. T., Katsonis, Nathalie

“…The robustness and biocompatibility of bacterial nanocages holds promise for bio‐nanotechnologies. The propensity of these nano‐carriers to penetrate cells has…”
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Phototriggered cargo release from virus-like assemblies by Brasch, Melanie, Voets, Ilja K, Koay, Melissa S T, Cornelissen, Jeroen J L M

“…There has been tremendous progress towards the development of responsive polymers that are programmed to respond to an external stimulus such as light, pH and…”
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Self-assembly and characterization of small and monodisperse dye nanospheres in a protein cage by Luque, Daniel, de la Escosura, Andres, Snijder, Joost, Brasch, Melanie, Burnley, Rebecca J, Koay, Melissa ST, Carrascosa, Jose L, Wuite, Gijs JL, Roos, Wouter H, Heck, Albert JR, Cornelissen, Jeroen JLM, Torres, Tomas, Caston, Jose R

“…Phthalocyanines (Pc) are dyes in widespread use in materials science and nanotechnology, with numerous applications in medicine, photonics, electronics and…”
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A Non-hydrolyzable ATP Derivative Generates a Stable Complex in a Light-inducible Two-component System by Sharda, Shivani, Koay, Melissa S.T., Kim, Young-Jun, Engelhard, Martin, Gärtner, Wolfgang

“…Isothermal calorimetry (ITC) measurements yielded the binding constants during complex formation of light-inducible histidine kinases (HK) and their cognate…”
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Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology by Golynskiy, Misha V, Koay, Melissa S, Vinkenborg, Jan L, Merkx, Maarten

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Modelling Low-Potential [Fe4S4] Clusters in Proteins by Koay, Melissa S., Antonkine, Mikhail L., Gärtner, Wolfgang, Lubitz, Wolfgang

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Fluorescent imaging of transition metal homeostasis using genetically encoded sensors by Vinkenborg, Jan L, Koay, Melissa S, Merkx, M

“…The ability to image the concentration of transition metals in living cells in real time is important for understanding transition metal (TM) homeostasis and…”
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Self-Assembled Cage-Like Protein Structures by Putri, Rindia M., Cornelissen, Jeroen J. L. M., Koay, Melissa S. T.

“…Proteins and protein‐based assemblies represent the most structurally and functionally diverse molecules found in nature. Protein cages, viruses and bacterial…”
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Synthesis and characterization of de novo designed peptides modelling the binding sites of [4Fe–4S] clusters in photosystem I by Antonkine, Mikhail L., Koay, Melissa S., Epel, Boris, Breitenstein, Christoph, Gopta, Oxana, Gärtner, Wolfgang, Bill, Eckhard, Lubitz, Wolfgang

“…Photosystem I (PS I) converts the energy of light into chemical energy via transmembrane charge separation. The terminal electron transfer cofactors in PS I…”
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