Search Results - "Koźmiński, Przemysław"
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Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers
Published in International journal of molecular sciences (14-05-2020)“…Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and…”
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Design, Synthesis and Molecular Modeling Study of Radiotracers Based on Tacrine and Its Derivatives for Study on Alzheimer’s Disease and Its Early Diagnosis
Published in Applied sciences (01-04-2024)“…From 1993 to 2013, tacrine was an approved drug for Alzheimer’s disease. Due to its strong inhibitory properties towards cholinesterase, tacrine causes an…”
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Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine
Published in Molecular pharmaceutics (04-01-2021)“…Methotrexate is a gold standard among disease modifying antirheumatic drugs and is also extensively used clinically in combination with oncological therapies…”
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Synthesis and in vitro / in vivo evaluation of novel mono- and trivalent technetium-99m labeled ghrelin peptide complexes as potential diagnostic radiopharmaceuticals
Published in Nuclear medicine and biology (01-01-2015)“…Abstract Introduction Ghrelin is an endogenous hormone present in blood. It is released from the oxyntic cells (X/A-like cells) of the stomach and fundus and…”
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Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of 99mTc-Labelled Methotrexate
Published in Molecules (Basel, Switzerland) (27-09-2021)“…The aim of the work carried out was to draw attention to shortcomings that often appear at the stage of designing new radiopharmaceuticals. Based on a case…”
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Synthesis and Physicochemical Properties of Cefepime Derivatives Suitable for Labeling with Gallium-68
Published in Applied sciences (01-04-2023)“…Bone and soft tissue infections are potentially life-threatening and require immediate and intensive treatment. However, there is still no single diagnostic…”
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Synthesis, physicochemical and in vitro biological evaluation of 99mTc-cefepime radioconjugates, and development of DTPA-cefepime single vial kit formulation for labelling with technetium-99m
Published in Journal of radioanalytical and nuclear chemistry (2022)“…In the present work the synthesis, physicochemical properties and biological evaluation of cefepime (CFM) labelled with technetium-99m were studied. Two…”
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Application of Neurokinin-1 Receptor in Targeted Strategies for Glioma Treatment. Part I: Synthesis and Evaluation of Substance P Fragments Labeled with 99mTc and 177Lu as Potential Receptor Radiopharmaceuticals
Published in Molecules (Basel, Switzerland) (05-10-2018)“…Gliomas, particularly WHO grade IV glioblastoma multiforme, are one of the most common and aggressive primary tumors of the central nervous system. The…”
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99mTc-Labeled Vasopressin Peptide as a Radiopharmaceutical for Small-Cell Lung Cancer (SCLC) Diagnosis
Published in Journal of medicinal chemistry (24-07-2014)“…The 99mTc-labeled conjugates of the vasopressin (AVP) peptide and of its analogue d(CH2)5[d-Tyr(Et2)-Ile4-Eda9]AVP (AVP(an)) have been synthesized using the…”
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
Published in Pharmaceutics (10-03-2022)“…Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1…”
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Physicochemical and Biological Study of 99mTc and 68Ga Radiolabelled Ciprofloxacin and Evaluation of [99mTc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
Published in Tomography (Ann Arbor) (01-12-2021)“…This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of…”
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12
Synthesis and In Vitro Evaluation of Gold Nanoparticles Functionalized with Thiol Ligands for Robust Radiolabeling with 99mTc
Published in Nanomaterials (Basel, Switzerland) (15-09-2021)“…Radiolabeled gold nanoparticles (AuNPs) have been widely used for cancer diagnosis and therapy over recent decades. In this study, we focused on the…”
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Lu-Labeled Iron Oxide Nanoparticles Functionalized with Doxorubicin and Bevacizumab as Nanobrachytherapy Agents against Breast Cancer
Published in Molecules (Basel, Switzerland) (01-02-2024)“…The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the…”
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177 Lu-Labeled Iron Oxide Nanoparticles Functionalized with Doxorubicin and Bevacizumab as Nanobrachytherapy Agents against Breast Cancer
Published in Molecules (Basel, Switzerland) (27-02-2024)“…The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the…”
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15
99m Tc-Labeled Vasopressin Peptide as a Radiopharmaceutical for Small-Cell Lung Cancer (SCLC) Diagnosis
Published in Journal of medicinal chemistry (24-07-2014)Get full text
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16
In Vitro Biological Evaluation of Aprepitant Based 177 Lu-Radioconjugates
Published in Pharmaceutics (10-03-2022)“…Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1…”
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17
Novel NK1R-Targeted 68 Ga-/ 177 Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure-Activity Relationships
Published in International journal of molecular sciences (21-01-2022)“…Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far,…”
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18
Physicochemical and Biological Study of 99m Tc and 68 Ga Radiolabelled Ciprofloxacin and Evaluation of [ 99m Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
Published in Tomography (Ann Arbor) (01-12-2021)“…This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of…”
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Journal Article -
19
177Lu-Labeled Iron Oxide Nanoparticles Functionalized with Doxorubicin and Bevacizumab as Nanobrachytherapy Agents against Breast Cancer
Published in Molecules (Basel, Switzerland) (27-02-2024)“…The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the…”
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Journal Article -
20
Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships
Published in International journal of molecular sciences (21-01-2022)“…Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far,…”
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