Search Results - "Ko, Young H"

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy by Mathupala, Saroj P, Ko, Young H, Pedersen, Peter L

“…Abstract The most common metabolic hallmark of malignant tumors, i.e., the “Warburg effect” is their propensity to metabolize glucose to lactic acid at a high…”
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The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate by Lis, Paweł, Dyląg, Mariusz, Niedźwiecka, Katarzyna, Ko, Young H, Pedersen, Peter L, Goffeau, Andre, Ułaszewski, Stanisław

“…This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the "Warburg" and "Crabtree" effects…”
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The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies by Mathupala, Saroj P., Ko, Young H., Pedersen, Peter L.

“…Tumors usurp established metabolic steps used by normal tissues for glucose utilization and ATP production that rely heavily on mitochondria and employ a route…”
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Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorders by Park, Sanghui, Ko, Young H.

“…Primary infection with Epstein–Barr virus (EBV) is usually asymptomatic and, in a normal host, EBV remains latent in B cells after primary infection for the…”
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Extranodal Natural Killer T-Cell Lymphoma, Nasal-Type: A Prognostic Model From a Retrospective Multicenter Study by LEE, Jeeyun, SUH, Cheolwon, HYO JIN KIM, SOON IL LEE, JUNG HAN KIM, PARK, Jinny, SEOK JOONG OH, KIM, Kihyun, JUNG, Chulwon, PARK, Keunchil, WON SEOG KIM, YEON HEE PARK, KO, Young H, SOO MEE BANG, JAE HOON LEE, DAE HO LEE, HUH, Jooryung, SUNG YONG OH, KWON, Hyuk-Chan

“…Patients with natural killer T (NK/T) -cell lymphomas have poor survival outcome, and for this condition there is no optimal therapy. The purpose of this study…”
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The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH by Azevedo-Silva, João, Queirós, Odília, Ribeiro, Ana, Baltazar, Fátima, Young, Ko H, Pedersen, Peter L, Preto, Ana, Casal, Margarida

“…Although the anti-cancer properties of 3BP (3-bromopyruvate) have been described previously, its selectivity for cancer cells still needs to be explained [Ko…”
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Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia by Pereira-Vieira, Joana, Weber, Daniela D, Silva, Sâmia, Barbosa-Matos, Catarina, Granja, Sara, Reis, Rui Manuel, Queirós, Odília, Ko, Young H, Kofler, Barbara, Casal, Margarida, Baltazar, Fátima

“…Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need…”
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Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: Overlap with chronic active EBV infection and infantile fulminant EBV T-LPD by Ohshima, Koichi, Kimura, Hiroshi, Yoshino, Tadashi, Kim, Chul Woo, Ko, Young H., Lee, Seung-Suk, Peh, Suat-Cheng, Chan, John K.C.

“…EBV‐associated T/natural killer (NK)‐cell lymphoproliferative disorder (EBV‐T/NK LPD) of children and young adults is generally referred to with the blanket…”
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Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP by Ko, Young H., Smith, Barbara L., Wang, Yuchuan, Pomper, Martin G., Rini, David A., Torbenson, Michael S., Hullihen, Joanne, Pedersen, Peter L.

“…A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether…”
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SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids by Roy, Sanjit, Dukic, Tijana, Keepers, Zachery, Bhandary, Binny, Lamichhane, Narottam, Molitoris, Jason, Ko, Young H., Banerjee, Aditi, Shukla, Hem D.

“…Pancreatic cancer has a five-year survival rate of only 10%, mostly due to late diagnosis and limited treatment options. In patients with unresectable disease,…”
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Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome by Han, A-Reum, Lee, Hye Ran, Park, Byeong-Bae, Hwang, In Gyu, Park, Sarah, Lee, Sang Cheol, Kim, Kihyun, Lim, Ho Yeong, Ko, Young H, Kim, Sun Hee, Kim, Won Seog

“…The clinical features and prognostic factor of lymphoma-associated hemophagocytic syndrome (LAHS), diagnosed according to World Health Organization…”
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Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma by Geschwind, Jean-Francois, Georgiades, Christos S, Ko, Young H, Pedersen, Peter L

“…It has long been known that tumors depend on energy production pathways that are different from those of normal cells. These unique pathways require the…”
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Dysregulated metabolism contributes to oncogenesis by Hirschey, Matthew D, DeBerardinis, Ralph J, Diehl, Anna Mae E, Drew, Janice E, Frezza, Christian, Green, Michelle F, Jones, Lee W, Ko, Young H, Le, Anne, Lea, Michael A, Locasale, Jason W, Longo, Valter D, Lyssiotis, Costas A, McDonnell, Eoin, Mehrmohamadi, Mahya, Michelotti, Gregory, Muralidhar, Vinayak, Murphy, Michael P, Pedersen, Peter L, Poore, Brad, Raffaghello, Lizzia, Rathmell, Jeffrey C, Sivanand, Sharanya, Vander Heiden, Matthew G, Wellen, Kathryn E

“…Abstract Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic…”
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3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau by Ko, Young H., Niedźwiecka, Katarzyna, Casal, Margarida, Pedersen, Peter L., Ułaszewski, Stanisław

“…3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were…”
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Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential by Chen, Ying-Bei, Aon, Miguel A, Hsu, Yi-Te, Soane, Lucian, Teng, Xinchen, McCaffery, J Michael, Cheng, Wen-Chih, Qi, Bing, Li, Hongmei, Alavian, Kambiz N, Dayhoff-Brannigan, Margaret, Zou, Shifa, Pineda, Fernando J, O'Rourke, Brian, Ko, Young H, Pedersen, Peter L, Kaczmarek, Leonard K, Jonas, Elizabeth A, Hardwick, J Marie

“…Mammalian Bcl-x(L) protein localizes to the outer mitochondrial membrane, where it inhibits apoptosis by binding Bax and inhibiting Bax-induced outer membrane…”
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Multimodal Imaging of Pancreatic Cancer Microenvironment in Response to an Antiglycolytic Drug by Sheikh, Elnaz, Agrawal, Kirti, Roy, Sanjit, Burk, David, Donnarumma, Fabrizio, Ko, Young H., Guttula, Praveen Kumar, Biswal, Nrusingh C., Shukla, Hem D., Gartia, Manas Ranjan

“…Lipid metabolism and glycolysis play crucial roles in the progression and metastasis of cancer, and the use of 3‐bromopyruvate (3‐BP) as an antiglycolytic…”
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Prospective clinical study of surgical resection followed by CHOP in localized intestinal diffuse large B cell lymphoma by Lee, Jeeyun, Kim, Won Seog, Kim, Kihyun, Ahn, Jin Seok, Jung, Chul Won, Lim, Ho-Yeong, Kang, Won Ki, Park, Keunchil, Ko, Young H, Kim, Young Ho, Park, Chimin, Yoon, Sung Hyun, Lee, Woo Yong, Chun, Ho Kyung

“…Abstract This study aimed to assess the efficacy of surgical treatment followed by post-surgical CHOP chemotherapy and to analyze the impact of T and N stage…”
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Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma by Niedźwiecka, Katarzyna, Dyląg, Mariusz, Augustyniak, Daria, Majkowska-Skrobek, Grażyna, Cal-Bąkowska, Magdalena, Ko, Young H, Pedersen, Peter L, Goffeau, Andre, Ułaszewski, Stanisław

“…In different fungal and algal species, the intracellular concentration of reduced glutathione (GSH) correlates closely with their susceptibility to killing by…”
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3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model by Roy, Sanjit, Dukic, Tijana, Bhandary, Binny, Tu, Kevin J, Molitoris, Jason, Ko, Young H, Shukla, Hem D

“…Pancreatic cancer (PC) is the fourth-most-deadly cancer in the United States with a 5-year survival rate of only 8%. The majority of patients with locally…”
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Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP by Ko, Young H, Delannoy, Michael, Hullihen, Joanne, Chiu, Wah, Pedersen, Peter L

“…The terminal step of ATP synthesis in intact mitochondria is catalyzed by the ATP synthase (F(0)F(1)) that works in close synchrony with the P(i) and ADP/ATP…”
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