Breast Reconstruction Use and Impact on Surgical and Oncologic Outcomes Amongst Inflammatory Breast Cancer Patients-A Systematic Review

Breast Reconstruction Use and Impact on Surgical and Oncologic Outcomes Amongst Inflammatory Breast Cancer Patients-A Systematic Review

Breast reconstruction is generally discouraged in women with inflammatory breast cancer (IBC) due to concerns with recurrence and poor long-term survival. We aim to determine contemporary trends and predictors of breast reconstruction and its impact on oncologic outcomes among women with IBC. A syst...

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Bibliographic Details
Published in:Current oncology (Toronto) Vol. 30; no. 7; pp. 6666 - 6681
Main Authors: Nair, Ananya Gopika, Ko, Gary Tsun Yin, Semple, John Laurie, Lim, David Wai
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-07-2023
MDPI
Subjects:
Breast cancer
breast reconstruction
Cancer patients
Care and treatment
immediate reconstruction
inflammatory breast cancer
Mammaplasty
Patient outcomes
survival
Systematic Review
Canada
Ontario
immediate reconstruction
inflammatory breast cancer
breast reconstruction
survival
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Summary:Breast reconstruction is generally discouraged in women with inflammatory breast cancer (IBC) due to concerns with recurrence and poor long-term survival. We aim to determine contemporary trends and predictors of breast reconstruction and its impact on oncologic outcomes among women with IBC. A systematic literature review for all studies published up to 15 September 2022 was conducted via MEDLINE, Embase, and the Cochrane Library. Studies comparing women diagnosed with IBC undergoing a mastectomy with or without breast reconstruction were evaluated. The initial search yielded 225 studies, of which nine retrospective cohort studies, reporting 2781 cases of breast reconstruction in 29,058 women with IBC, were included. In the past two decades, immediate reconstruction rates have doubled. Younger age, higher income (>USD 25,000), private insurance, metropolitan residence, and bilateral mastectomy were associated with immediate reconstruction. No significant difference was found in overall survival, breast cancer-specific survival or recurrence rates between women undergoing versus not undergoing (immediate or delayed) reconstruction. There is a paucity of data on delayed breast reconstruction following IBC. Immediate breast reconstruction may be a consideration for select patients with IBC, although prospective data is needed to clarify its safety.
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This work was presented as an e-poster presentation at the Canadian Surgery Forum, 15–17 September 2022, in Toronto, Ontario, Canada and the American College of Surgeons Clinical Congress, 16–20 October 2022, in San Diego, California, USA.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol30070489