Search Results - "Ko, Emily Mills"

Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders by Hughes, Heather K, Mills Ko, Emily, Rose, Destanie, Ashwood, Paul

“…Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that are highly variable and are clinically characterized by deficits in…”
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Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model by Guo, Fuzheng, Bannerman, Peter, Mills Ko, Emily, Miers, Laird, Xu, Jie, Burns, Travis, Li, Shuo, Freeman, Ernest, McDonough, Jennifer A., Pleasure, David

“…Canavan disease is caused by inactivating ASPA (aspartoacylase) mutations that prevent cleavage of N‐acetyl‐L‐aspartate (NAA), resulting in marked elevations…”
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The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice by Sohn, Jiho, Orosco, Lori, Guo, Fuzheng, Chung, Seung-Hyuk, Bannerman, Peter, Mills Ko, Emily, Zarbalis, Kostas, Deng, Wenbin, Pleasure, David

“…Astrocytes are the most abundant cells in the CNS, and have many essential functions, including maintenance of blood-brain barrier integrity, and CNS water,…”
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Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model by Mills Ko, Emily, Ma, Joyce H, Guo, Fuzheng, Miers, Laird, Lee, Eunyoung, Bannerman, Peter, Burns, Travis, Ko, David, Sohn, Jiho, Soulika, Athena M, Pleasure, David

“…Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for…”
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Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats by Arzi, Boaz, Mills-Ko, Emily, Verstraete, Frank J.M., Kol, Amir, Walker, Naomi J., Badgley, Megan R., Fazel, Nasim, Murphy, William J., Vapniarsky, Natalia, Borjesson, Dori L.

“…Mesenchymal stem cells (MSCs) are a promising therapy for immune‐mediated and inflammatory disorders, because of their potent immunomodulatory properties. In…”
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Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE by Moreno, Monica, Guo, Fuzheng, Ko, Emily Mills, Bannerman, Peter, Soulika, Athena, Pleasure, David

“…Abstract Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive…”
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Differential Macrophage Responses in Affective Versus Non-Affective First-Episode Psychosis Patients by Hughes, Heather K, Mills-Ko, Emily, Yang, Houa, Lesh, Tyler A, Carter, Cameron S, Ashwood, Paul

“…Increased innate immune activation and inflammation are common findings in psychotic and affective (mood) disorders such as schizophrenia (SCZ), bipolar…”
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Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome by Clark, Kaitlin C, Fierro, Fernando A, Ko, Emily Mills, Walker, Naomi J, Arzi, Boaz, Tepper, Clifford G, Dahlenburg, Heather, Cicchetto, Andrew, Kol, Amir, Marsh, Lyndsey, Murphy, William J, Fazel, Nasim, Borjesson, Dori L

“…Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate…”
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Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis by Guo, Fuzheng, Maeda, Yoshiko, Ma, Joyce, Delgado, Monica, Sohn, Jiho, Miers, Laird, Ko, Emily Mills, Bannerman, Peter, Xu, Jie, Wang, Yazhou, Zhou, Chengji, Takebayashi, Hirohide, Pleasure, David

“…Accumulations of hypertrophic, intensely glial fibrillary acidic protein-positive (GFAP(+)) astroglia, which also express immunoreactive nestin and vimentin,…”
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Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development by Guo, Fuzheng, Maeda, Yoshiko, Ko, Emily Mills, Delgado, Monica, Horiuchi, Makoto, Soulika, Athena, Miers, Laird, Burns, Travis, Itoh, Takayuki, Shen, Haitao, Lee, Eunyoung, Sohn, Jiho, Pleasure, David

“…Pharmacological studies have suggested that oligodendroglial NMDA glutamate receptors (NMDARs) mediate white matter injury in a variety of CNS diseases,…”
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Enhanced Phenotypic Alterations of Alveolar Type II Cells in Response to Aflatoxin G1-Induced Lung Inflammation by Shen, Haitao, Liu, Chunping, Shao, Peilu, Yi, Li, Wang, Yuan, Mills Ko, Emily, Tian, Ziqiang, Zhao, Xin, Wang, Juan, Xing, Lingxiao, Zhang, Xianghong

“…Recently, we discovered that Aflatoxin G1 (AFG1) induces chronic lung inflammatory responses, which may contribute to lung tumorigenesis in Balb/C mice. The…”
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Ablating N ‐acetylaspartate prevents leukodystrophy in a C anavan disease model by Guo, Fuzheng, Bannerman, Peter, Mills Ko, Emily, Miers, Laird, Xu, Jie, Burns, Travis, Li, Shuo, Freeman, Ernest, McDonough, Jennifer A., Pleasure, David

“…Canavan disease is caused by inactivating ASPA (aspartoacylase) mutations that prevent cleavage of N‐acetyl‐L‐aspartate (NAA), resulting in marked elevations…”
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Enhanced Phenotypic Alterations of Alveolar Type II Cells in Response to Aflatoxin G 1 ‐Induced Lung Inflammation by Shen, Haitao, Liu, Chunping, Shao, Peilu, Yi, Li, Wang, Yuan, Mills Ko, Emily, Tian, Ziqiang, Zhao, Xin, Wang, Juan, Xing, Lingxiao, Zhang, Xianghong

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Myelin and re-myelination in Multiple Sclerosis and Canavan Disease by Mills Ko, Emily

“…Myelin sheath formation around axons is fundamentally important for central nervous system (CNS) function. Understanding the process of myelination, and the…”
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