Search Results - "Knudson, Isaac J."
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β‑Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism
Published in ACS central science (26-06-2024)“…Templated synthesis of proteins containing non-natural amino acids (nnAAs) promises to expand the chemical space available to biological therapeutics and…”
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Flipping the Switch: Reverse-Demand Voltage-Sensitive Fluorophores
Published in Journal of the American Chemical Society (27-07-2022)“…Fluorescence microscopy with fluorescent reporters that respond to environmental cues is a powerful method for interrogating biochemistry and biophysics in…”
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Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates
Published in Nature chemistry (01-07-2023)“…As genetic code expansion advances beyond l -α-amino acids to backbone modifications and new polymerization chemistries, delineating what substrates the…”
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Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression
Published in Molecular and cellular biology (01-10-2018)“…The organization of the five β-type globin genes on chromosome 11 reflects the timing of expression during erythroid cell development, with the embryonic…”
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Engineered Zinc Finger DNA-Binding Domains: Synthesis, Assessment of DNA-Binding Affinity, and Direct Protein Delivery to Mammalian Cells
Published in Methods in molecular biology (Clifton, N.J.) (2017)“…Zinc finger proteins are the most common among families of DNA-binding transcription factors. Designer transcription factors generated by the fusion of…”
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