Search Results - "Knudson, G A"

Antioncogenes and Human Cancer by Knudson, Alfred G.

“…The antioncogenes, or tumor suppressor genes, as negative regulators of cell division, stand in contrast to oncogenes. For most human cancers, the more…”
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Inverse Radiation Dose-Rate Effects on Somatic and Germ-Line Mutations and DNA Damage Rates by Vilenchik, Michael M., Knudson, Alfred G.

“…The mutagenic effect of low linear energy transfer ionizing radiation is reduced for a given dose as the dose rate (DR) is reduced to a low level, a phenomenon…”
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Hereditary cancer : two hits revisited by KNUDSON, A. G

“…According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic,…”
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CHASING THE CANCER DEMON by Knudson, Alfred G

“…Boveri's idea that somatic mutations are at the root of cancer found its first specific support with the investigation of leukemia and Burkitt's lymphoma, and…”
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Hereditary cancer, oncogenes, and antioncogenes by KNUDSON, A. G. JR

“…The somatic mutational hypothesis for the origin of cancer carries several implications of importance: (a) spontaneous mutations should produce some…”
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Of sea urchins and worms: development and cancer by Knudson, A G

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Two genetic hits (more or less) to cancer by Knudson, Alfred G

“…Most cancers have many chromosomal abnormalities, both in number and in structure, whereas some show only a single aberration. In the era before molecular…”
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Predisposition to Renal Carcinoma in the Eker Rat is Determined by Germ-Line Mutation of the Tuberous Sclerosis 2 (TSC2) Gene by Yeung, R S, Xiao, G H, Jin, F, Lee, W C, Testa, J R, Knudson, A G

“…Genetic predisposition to neoplasia often involves tumor suppressor genes. One such model of hereditary renal carcinoma was described in the rat by Eker. These…”
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Genetics of Human Cancer by Knudson, A G

“…Study of hereditary cancer in humans has revealed new mechanisms in carcinogenesis. In particular, a new class of cancer gene, recessive in oncogenesis,…”
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Endogenous DNA Double-Strand Breaks: Production, Fidelity of Repair, and Induction of Cancer by Vilenchik, Michael M., Knudson, Alfred G.

“…This article extends our previous quantitative analysis of the relationship between the dynamics of the primary structure of DNA and mutagenesis associated…”
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Spontaneous and Radiation-Induced Renal Tumors in the Eker Rat Model of Dominantly Inherited Cancer by Hino, Okio, Andres J. P. Klein-Szanto, Freed, Jerome J., Testa, Joseph R., Brown, Darrell Q., Vilensky, Maria, Yeung, Raymond S., Tartof, Kenneth D., Knudson, Alfred G.

“…Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer…”
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The ninth Gordon Hamilton-Fairley memorial lecture : Hereditary cancers: clues to mechanisms of carcinogenesis by Knudson, Jr, A G

“…The study of hereditary cancer in humans, notably retinoblastoma, has identified a category of cancer genes that is different from that of the oncogenes…”
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Susceptibility to Renal Carcinoma in the Eker Rat Involves a Tumor Suppressor Gene on Chromosome 10 by Yeung, Raymond S., Buetow, Kenneth H., Testa, Joseph R., Knudson, Alfred G.

“…Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC)…”
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Mutation and cancer: a model for human carcinogenesis by Moolgavkar, S H, Knudson, Jr, A G

“…A model for carcinogenesis is presented that provides a framework for understanding the roles of "spontaneous" events, hereditary factors, and environmental…”
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Altered expression of transforming growth factor-α in hereditary rat renal cell carcinoma by WALKER, C, EVERITT, J, FREED, J. J, KNUDSON, A. G, WHITELEY, L. O

“…A hereditary form of renal cell carcinoma exists in rats that results from a single gene mutation and is histologically similar to that described in humans…”
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Hereditary cancers disclose a class of cancer genes by Knudson, Jr, A G

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Susumu Ohno: remembrance of things past by Knudson, A G

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Pediatric molecular oncology. Past as prologue to the future by Knudson, Jr, A G

“…The great successes in the treatment of childhood cancers have been followed in recent years with a new understanding of the molecular genetic abnormalities…”
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Genetic predisposition to transplacentally induced renal cell carcinomas in the eker rat by HINO, O, MITANI, H, KNUDSON, A. G

“…N-Ethyl-N-nitrosourea-induced transplacental renal carcinogenesis in the rat results primarily in Wilms' tumors, apparently because primitive nephroblasts are…”
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Meeting Report: Genetic Environmental Interactions in Cancer Susceptibility in Animal Models by Knudson, A G, Hino, O

“…Knudson and Hino present a report from the US-Japan conference on "Genetic and Environmental Interactions in Cancer Susceptibility in Animal Models."…”
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