Search Results - "Knudsen, Thomas B"

Zebrafish-As an integrative model for twenty-first century toxicity testing by Sipes, Nisha S., Padilla, Stephanie, Knudsen, Thomas B.

“…The zebrafish embryo is a useful small model for investigating vertebrate development because of its transparency, low cost, transgenic and morpholino…”
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Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data by Reif, David M., Martin, Matthew T., Tan, Shirlee W., Houck, Keith A., Judson, Richard S., Richard, Ann M., Knudsen, Thomas B., Dix, David J., Kavlock, Robert J.

“…Background: The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I…”
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Computational Model of Secondary Palate Fusion and Disruption by Hutson, M. Shane, Leung, Maxwell C. K, Baker, Nancy C, Spencer, Richard M, Knudsen, Thomas B

“…Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from…”
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Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function by Papadopoulos, Vassilios, Baraldi, Mario, Guilarte, Tomás R., Knudsen, Thomas B., Lacapère, Jean-Jacques, Lindemann, Peter, Norenberg, Michael D., Nutt, David, Weizman, Abraham, Zhang, Ming-Rong, Gavish, Moshe

“…The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is located mainly in the outer…”
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Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data by Sipes, Nisha S., Martin, Matthew T., Reif, David M., Kleinstreuer, Nicole C., Judson, Richard S., Singh, Amar V., Chandler, Kelly J., Dix, David J., Kavlock, Robert J., Knudsen, Thomas B.

“…Environmental Protection Agency's ToxCast project is profiling the in vitro bioactivity of chemicals to assess pathway-level and cell-based signatures that…”
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Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling by Pierro, Jocylin D, Ahir, Bhavesh K, Baker, Nancy C, Kleinstreuer, Nicole C, Xia, Menghang, Knudsen, Thomas B

“…All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors during…”
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Identification of estrogen target genes during zebrafish embryonic development through transcriptomic analysis by Hao, Ruixin, Bondesson, Maria, Singh, Amar V, Riu, Anne, McCollum, Catherine W, Knudsen, Thomas B, Gorelick, Daniel A, Gustafsson, Jan-Åke

“…Estrogen signaling is important for vertebrate embryonic development. Here we have used zebrafish (Danio rerio) as a vertebrate model to analyze estrogen…”
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Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment by Judson, Richard S, Kavlock, Robert J, Setzer, R. Woodrow, Cohen Hubal, Elaine A, Martin, Matthew T, Knudsen, Thomas B, Houck, Keith A, Thomas, Russell S, Wetmore, Barbara A, Dix, David J

“…We describe a framework for estimating the human dose at which a chemical significantly alters a biological pathway in vivo, making use of in vitro assay data…”
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Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes by Benakanakere, Manjunatha R., Li, Qiyan, Eskan, Mehmet A., Singh, Amar V., Zhao, Jiawei, Galicia, Johnah C., Stathopoulou, Panagiota, Knudsen, Thomas B., Kinane, Denis F.

“…Mammalian biological processes such as inflammation, involve regulation of hundreds of genes controlling onset and termination. MicroRNAs (miRNAs) can…”
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Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity by Judson, Richard S, Martin, Matthew T, Reif, David M, Houck, Keith A, Knudsen, Thomas B, Rotroff, Daniel M, Xia, Menghang, Sakamuru, Srilatha, Huang, Ruili, Shinn, Paul, Austin, Christopher P, Kavlock, Robert J, Dix, David J

“…The Deepwater Horizon oil spill has led to the use of >1 M gallons of oil spill dispersants, which are mixtures of surfactants and solvents. Because of this…”
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Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis by States, J Christopher, Singh, Amar V, Knudsen, Thomas B, Rouchka, Eric C, Ngalame, Ntube O, Arteel, Gavin E, Piao, Yulan, Ko, Minoru S H

“…The mechanisms by which environmental toxicants alter developmental processes predisposing individuals to adult onset chronic disease are not well-understood…”
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Disruption of embryonic vascular development in predictive toxicology by Knudsen, Thomas B., Kleinstreuer, Nicole C.

“…Toxicity testing in the 21st century is moving toward using high‐throughput screening assays to rapidly test thousands of chemicals against hundreds of…”
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Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion by Nguyen, Eric H., Daly, William T., Le, Ngoc Nhi T., Farnoodian, Mitra, Belair, David G., Schwartz, Michael P., Lebakken, Connie S., Ananiev, Gene E., Saghiri, Mohammad Ali, Knudsen, Thomas B., Sheibani, Nader, Murphy, William L.

“…The physiological relevance of Matrigel as a cell-culture substrate and in angiogenesis assays is often called into question. Here, we describe an array-based…”
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Excellence paves the way with Current Research in Toxicology by Knudsen, Thomas B., Vinken, Mathieu

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Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay by Chandler, Kelly J, Barrier, Marianne, Jeffay, Susan, Nichols, Harriette P, Kleinstreuer, Nicole C, Singh, Amar V, Reif, David M, Sipes, Nisha S, Judson, Richard S, Dix, David J, Kavlock, Robert, Hunter, 3rd, Edward S, Knudsen, Thomas B

“…The vast landscape of environmental chemicals has motivated the need for alternative methods to traditional whole-animal bioassays in toxicity testing…”
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In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis by Kleinstreuer, Nicole C, Dix, David J, Houck, Keith A, Kavlock, Robert J, Knudsen, Thomas B, Martin, Matthew T, Paul, Katie B, Reif, David M, Crofton, Kevin M, Hamilton, Kerry, Hunter, Ronald, Shah, Imran, Judson, Richard S

“…Thousands of untested chemicals in the environment require efficient characterization of carcinogenic potential in humans. A proposed solution is rapid testing…”
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Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB by Knudsen, Thomas B., Martin, Matthew T., Kavlock, Robert J., Judson, Richard S., Dix, David J., Singh, Amar V.

“…As the primary source for regulatory developmental toxicity information, prenatal studies characterize maternal effects and fetal endpoints including…”
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Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature by Baker, Nancy C., Sipes, Nisha S., Franzosa, Jill, Belair, David G., Abbott, Barbara D., Judson, Richard S., Knudsen, Thomas B.

“…Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it…”
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Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action by Basu, Madhumita, Howdeshell, Kembra L., Rasmussen, Sonja A., Rychlik, Kristal A., Knudsen, Thomas B., Shuey, Dana L., Slikker, William

“…The Society for Birth Defects Research and Prevention (BDRP) strives to understand and protect against potential hazards to developing embryos, fetuses,…”
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Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome by Green, Maia L., Singh, Amar V., Zhang, Yihzi, Nemeth, Kimberly A., Sulik, Kathleen K., Knudsen, Thomas B.

“…Fetal Alcohol Spectrum Disorders (FASD) are birth defects that result from maternal alcohol use. We used a non a priori approach to prioritize candidate…”
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