Search Results - "Knudsen, Karoline"

Clinical and imaging evidence of brain-first and body-first Parkinson's disease by Horsager, Jacob, Knudsen, Karoline, Sommerauer, Michael

“…Braak's hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not…”
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Constipation in parkinson's disease: Subjective symptoms, objective markers, and new perspectives by Knudsen, Karoline, Krogh, Klaus, Østergaard, Karen, Borghammer, Per

“…ABSTRACT Constipation is among the first nonmotor symptoms to develop in the prodromal phase of PD. Pathological alpha‐synuclein deposition is present…”
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Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study by Horsager, Jacob, Andersen, Katrine B, Knudsen, Karoline, Skjærbæk, Casper, Fedorova, Tatyana D, Okkels, Niels, Schaeffer, Eva, Bonkat, Sarah K, Geday, Jacob, Otto, Marit, Sommerauer, Michael, Danielsen, Erik H, Bech, Einar, Kraft, Jonas, Munk, Ole L, Hansen, Sandra D, Pavese, Nicola, Göder, Robert, Brooks, David J, Berg, Daniela, Borghammer, Per

“…Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like…”
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Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes by Knudsen, Karoline, Fedorova, Tatyana D, Horsager, Jacob, Andersen, Katrine B, Skjærbæk, Casper, Berg, Daniela, Schaeffer, Eva, Brooks, David J, Pavese, Nicola, Van Den Berge, Nathalie, Borghammer, Per

“…We have hypothesized that Parkinson's disease (PD) comprises two subtypes. Brain-first, where pathogenic α-synuclein initially forms unilaterally in one…”
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Preserved noradrenergic function in Parkinson's disease patients with rest tremor by Kinnerup, Martin B., Sommerauer, Michael, Damholdt, Malene F., Schaldemose, Jeppe L., Ismail, Rola, Terkelsen, Astrid J., Stær, Kristian, Hansen, Allan, Fedorova, Tatyana D., Knudsen, Karoline, Skjærbæk, Casper, Borghammer, Per, Pavese, Nicola, Brooks, David J., Nahimi, Adjmal

“…Noradrenergic neurotransmission may play an important role in tremor modulation through its innervation of key structures of the central tremor circuits. Here,…”
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Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies by Just, Mie Kristine, Gram, Hjalte, Theologidis, Vasileios, Jensen, Poul Henning, Nilsson, K Peter R, Lindgren, Mikael, Knudsen, Karoline, Borghammer, Per, Van Den Berge, Nathalie

“…Pathogenic alpha-synuclein (asyn) aggregates are a defining feature of neurodegenerative synucleinopathies, which include Parkinson's disease, Lewy body…”
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Intestinal Transit in Early Moderate Parkinson’s Disease Correlates with Probable RBD: Subclinical Esophageal Dysmotility Does Not Correlate by Skjærbæk, Casper, Knudsen, Karoline, Kinnerup, Martin, Hansen, Kim Vang, Borghammer, Per

“…Background. Nonmotor symptoms, including constipation and dysphagia, are very common in Parkinson’s disease (PD) and Lewy pathology is widespread in the…”
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Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study by Horsager, Jacob, Walter, Uwe, Fedorova, Tatyana D, Andersen, Katrine B, Skjærbæk, Casper, Knudsen, Karoline, Okkels, Niels, von Weitzel-Mudersbach, Paul, Dyrskog, Stig Eric, Bergholt, Bo, Borghammer, Per

“…Vagal parasympathetic neurons are prone to degeneration in Parkinson's disease (PD). High-resolution ultrasound can precisely estimate the cross-sectional…”
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Gastric Emptying Time and Volume of the Small Intestine as Objective Markers in Patients With Symptoms of Diabetic Enteropathy by Klinge, Mette W, Sutter, Nanna, Mark, Esben B, Haase, Anne-Mette, Borghammer, Per, Schlageter, Vincent, Lund, Sten, Fleischer, Jesper, Knudsen, Karoline, Drewes, Asbjørn M, Krogh, Klaus

“…Patients with diabetes mellitus (DM) often suffer from gastrointestinal (GI) symptoms, but these correlate poorly to established objective GI motility…”
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Evaluation of the noradrenergic system in Parkinson's disease: an 11C-MeNER PET and neuromelanin MRI study by Sommerauer, Michael, Fedorova, Tatyana D, Hansen, Allan K, Knudsen, Karoline, Otto, Marit, Jeppesen, Jesper, Frederiksen, Yoon, Blicher, Jakob U, Geday, Jacob, Nahimi, Adjmal, Damholdt, Malene F, Brooks, David J, Borghammer, Per

“…REM sleep behaviour disorder (RBD) in Parkinson's disease predicts an unfavourable disease course. Using multimodal imaging of the noradrenergic system,…”
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Skin Temperature in Parkinson’s Disease Measured by Infrared Thermography by Terkelsen, Astrid Juhl, Karlsson, Pall, Knudsen, Karoline, Purup, Mathias Møller, Borghammer, Per

“…Background. Patients with Parkinson’s disease (PD) often show peripheral autonomic dysfunction and depositions of pathological alpha-synuclein aggregates in…”
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Thyroid [123I]MIBG uptake in Parkinson’s disease and diabetes mellitus by Fedorova, Tatyana D., Knudsen, Karoline, Rasmussen, Thorsten K., Horsager, Jacob, Nahimi, Adjmal, Skjærbæk, Casper, Schaeffer, Eva, Berg, Daniela, Terkelsen, Astrid J., Borghammer, Per

“…Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson’s disease (PD) and diabetes mellitus (DM) on [123I]MIBG scintigraphies…”
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Synergy between Mecillinam and Ceftazidime/Avibactam or Avibactam against Multi-Drug-Resistant Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae by List, Karoline Knudsen, Kolpen, Mette, Kragh, Kasper Nørskov, Charbon, Godefroid, Radmer, Stine, Hansen, Frank, Løbner-Olesen, Anders, Frimodt-Møller, Niels, Hertz, Frederik Boetius

“…Background: Carbapenemase-producing Klebsiella pneumoniae and Escherichia coli have become a significant global health challenge. This has created an urgent…”
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Imaging Parkinson’s disease below the neck by Borghammer, Per, Knudsen, Karoline, Fedorova, Tatyana D., Brooks, David J.

“…Parkinson’s disease is a systemic disorder with widespread and early α -synuclein pathology in the autonomic and enteric nervous systems, which is present…”
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Gastrointestinal transit time and heart rate variability in patients with mild acquired brain injury by Enevoldsen, Johannes, Vistisen, Simon T, Krogh, Klaus, Nielsen, Jørgen F, Knudsen, Karoline, Borghammer, Per, Andersen, Henning

“…Constipation is suspected to occur frequently after acquired brain injury (ABI). In patients with ABI, heart rate variability (HRV) is reduced suggesting…”
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Imaging the Autonomic Nervous System in Parkinson’s Disease by Knudsen, Karoline, Borghammer, Per

“…Purpose of Review Patients with Parkinson’s disease (PD) often display gastrointestinal and genitourinary autonomic symptoms years or even decades prior to…”
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Radionuclide Imaging of the Gut-Brain Axis in Parkinson Disease by Horsager, Jacob, Knudsen, Karoline, Borghammer, Per

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Biomarkers for iron metabolism among patients hospitalized with community‐acquired pneumonia caused by infection with SARS‐CoV‐2, bacteria, and influenza by Hegelund, Maria Hein, Glenthøj, Andreas, Ryrsø, Camilla Koch, Ritz, Christian, Dungu, Arnold Matovu, Sejdic, Adin, List, Karoline Cecilie Knudsen, Krogh‐Madsen, Rikke, Lindegaard, Birgitte, Kurtzhals, Jørgen Anders Lindholm, Faurholt‐Jepsen, Daniel

“…Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID‐19. Few studies have investigated regulators of iron…”
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In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study by Knudsen, Karoline, Fedorova, Tatyana D, Hansen, Allan K, Sommerauer, Michael, Otto, Marit, Svendsen, Kristina B, Nahimi, Adjmal, Stokholm, Morten G, Pavese, Nicola, Beier, Christoph P, Brooks, David J, Borghammer, Per

“…Accumulating evidence suggests that α-synuclein aggregates—a defining pathology of Parkinson's disease—display cell-to-cell transmission. α-synuclein…”
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Gastric emptying in Parkinson's disease – A mini-review by Knudsen, Karoline, Szwebs, Martha, Hansen, Allan K., Borghammer, Per

“…Patients with Parkinson's disease (PD) experience a range of non-motor symptoms, including constipation and other gastrointestinal problems. These symptoms are…”
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