Search Results - "Knudsen, Erik S."

The history and future of targeting cyclin-dependent kinases in cancer therapy by Asghar, Uzma, Witkiewicz, Agnieszka K., Turner, Nicholas C., Knudsen, Erik S.

“…Key Points Cyclin-dependant kinase 4 (CDK4) and CDK6 phosphorylate the tumour suppressor retinoblastoma protein (RB), resulting in the release of the E2F…”
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Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities by Franco, Jorge, Balaji, Uthra, Freinkman, Elizaveta, Witkiewicz, Agnieszka K., Knudsen, Erik S.

“…Due to loss of p16ink4a in pancreatic ductal adenocarcinoma (PDA), pharmacological suppression of CDK4/6 could represent a potent target for treatment. In PDA…”
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The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies by Knudsen, Erik S, Witkiewicz, Agnieszka K

“…CDK4/6 inhibitors have emerged as a powerful class of agents with clinical activity in a number of malignancies. Targeting the cell cycle represents a core…”
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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets by Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.

“…Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109…”
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Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers by Knudsen, Erik S, Vail, Paris, Balaji, Uthra, Ngo, Hoai, Botros, Ihab W, Makarov, Vladimir, Riaz, Nadeem, Balachandran, Vinod, Leach, Steven, Thompson, Debrah M, Chan, Timothy A, Witkiewicz, Agnieszka K

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with an immunosuppressive milieu that supports immune system evasion and disease progression. Here, we…”
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Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions by Witkiewicz, Agnieszka K, Knudsen, Erik S

“…A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant…”
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MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies by Baek, GuemHee, Tse, Yan F., Hu, Zeping, Cox, Derek, Buboltz, Noah, McCue, Peter, Yeo, Charles J., White, Michael A., DeBerardinis, Ralph J., Knudsen, Erik S., Witkiewicz, Agnieszka K.

“…KRAS mutation, which occurs in ∼95% of pancreatic ductal adenocarcinoma (PDA), has been shown to program tumor metabolism. MCT4 is highly upregulated in a…”
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Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer by Jansen, Valerie M, Bhola, Neil E, Bauer, Joshua A, Formisano, Luigi, Lee, Kyung-Min, Hutchinson, Katherine E, Witkiewicz, Agnieszka K, Moore, Preston D, Estrada, Mónica Valéria, Sánchez, Violeta, Ericsson, Paula G, Sanders, Melinda E, Pohlmann, Paula R, Pishvaian, Michael J, Riddle, David A, Dugger, Teresa C, Wei, Wenyi, Knudsen, Erik S, Arteaga, Carlos L

“…Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) small-molecule inhibitors in breast cancer arises through mechanisms that are yet…”
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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism by Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

“…Our recent ERK1/2 inhibitor analyses in pancreatic ductal adenocarcinoma (PDAC) indicated ERK1/2-independent mechanisms maintaining MYC protein stability. To…”
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Targeting the RB-pathway in Cancer Therapy by KNUDSEN, Erik S, WANG, Jean Y. J

“…The RB-pathway, consisting of inhibitors and activators of cyclin-dependent kinases, the retinoblastoma tumor suppressor (RB), and the E2F-family of…”
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Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer by Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Conway, William, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.

“…Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic…”
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Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine by Knudsen, Erik S, O’Reilly, Eileen M, Brody, Jonathan R, Witkiewicz, Agnieszka K

“…Patients with pancreatic ductal adenocarcinoma (PDA) have a poor prognosis despite new treatments; approximately 7% survive for 5 years. Although there have…”
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Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors by Dean, Jeffry L., McClendon, A. Kathleen, Hickey, Theresa E., Butler, Lisa M., Tilley, Wayne D., Witkiewicz, Agnieszka K., Knudsen, Erik S.

“…To model the heterogeneity of breast cancer as observed in the clinic, we employed an ex vivo model of breast tumor tissue. This methodology maintained the…”
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Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer by Witkiewicz, Agnieszka K., Chung, Sejin, Brough, Rachel, Vail, Paris, Franco, Jorge, Lord, Christopher J., Knudsen, Erik S.

“…Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention…”
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Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via Metabolo-Genomics by Martinez-Outschoorn, Ubaldo E., Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S., Howell, Anthony, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P

“…Previously, we showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most…”
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Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease by Hutcheson, Jack, Balaji, Uthra, Porembka, Matthew R, Wachsmann, Megan B, McCue, Peter A, Knudsen, Erik S, Witkiewicz, Agnieszka K

“…Pancreatic ductal adenocarcinoma (PDA) is associated with an immunosuppressive microenvironment that supports the growth of the malignancy as well as immune…”
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The vulnerability of RB loss in breast cancer: Targeting a void in cell cycle control by Knudsen, Erik S, Zacksenhaus, Eldad

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The Aryl Hydrocarbon Receptor Functions as a Tumor Suppressor of Liver Carcinogenesis by YUNXIA FAN, BOIVIN, Gregory P, KNUDSEN, Erik S, NEBERT, Daniel W, YING XIA, PUGA, Alvaro

“…The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of its xenobiotic ligands…”
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The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression by Sharma, Ankur, Yeow, Wen-Shuz, Ertel, Adam, Coleman, Ilsa, Clegg, Nigel, Thangavel, Chellappagounder, Morrissey, Colm, Zhang, Xiaotun, Comstock, Clay E S, Witkiewicz, Agnieszka K, Gomella, Leonard, Knudsen, Erik S, Nelson, Peter S, Knudsen, Karen E

“…Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in tumorigenesis and acts in multiple cell types to suppress cell cycle…”
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The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy by Hutcheson, Jack, Witkiewicz, Agnieszka K, Knudsen, Erik S

“…The retinoblastoma tumor suppressor (RB) was the first identified tumor suppressor based on germline predisposition to the pediatric eye tumor. Since these…”
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