Search Results - "Knudsen, Charlotte R"

Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step by Hussey, George S., Chaudhury, Arindam, Dawson, Andrea E., Lindner, Daniel J., Knudsen, Charlotte R., Wilce, Matthew C.J., Merrick, William C., Howe, Philip H.

“…Transcript-selective translational regulation of epithelial-mesenchymal transition (EMT) by transforming growth factor-β (TGF-β) is directed by the hnRNP…”
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The Busiest of All Ribosomal Assistants: Elongation Factor Tu by Kavaliauskas, Darius, Nissen, Poul, Knudsen, Charlotte R

“…During translation, the nucleic acid language employed by genes is translated into the amino acid language used by proteins. The translator is the ribosome,…”
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Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu by Thirup, Søren S., Van, Lan Bich, Nielsen, Tine K., Knudsen, Charlotte R.

“…Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches…”
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Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases by Tzivelekidis, Tina, Jank, Thomas, Pohl, Corinna, Schlosser, Andreas, Rospert, Sabine, Knudsen, Charlotte R, Rodnina, Marina V, Belyi, Yury, Aktories, Klaus

“…Legionella pneumophila, which is the causative organism of Legionnaireś disease, translocates numerous effector proteins into the host cell cytosol by a type…”
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Structural dynamics of translation elongation factor Tu during aa-tRNA delivery to the ribosome by Kavaliauskas, Darius, Chen, Chunlai, Liu, Wei, Cooperman, Barry S, Goldman, Yale E, Knudsen, Charlotte R

“…Abstract The GTPase elongation factor EF-Tu delivers aminoacyl-tRNAs to the mRNA-programmed ribosome during translation. Cognate codon-anticodon interaction…”
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The Importance of P-loop and Domain Movements in EF-Tu for Guanine Nucleotide Exchange by Dahl, Louise D., Wieden, Hans-Joachim, Rodnina, Marina V., Knudsen, Charlotte R.

“…Elongation factor Ts (EF-Ts) is the guanine nucleotide exchange factor for elongation factor Tu (EF-Tu). An important feature of the nucleotide exchange is the…”
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EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways by Liu, Wei, Chen, Chunlai, Kavaliauskas, Darius, Knudsen, Charlotte R, Goldman, Yale E, Cooperman, Barry S

“…The G-protein EF-Tu, which undergoes a major conformational change when EF-Tu·GTP is converted to EF-Tu·GDP, forms part of an aminoacyl(aa)-tRNA·EF-Tu·GTP…”
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E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form by Johansen, Jesper S, Kavaliauskas, Darius, Pfeil, Shawn H, Blaise, Mickaël, Cooperman, Barry S, Goldman, Yale E, Thirup, Søren S, Knudsen, Charlotte R

“…Abstract According to the traditional view, GTPases act as molecular switches, which cycle between distinct 'on' and 'off' conformations bound to GTP and GDP,…”
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Mapping the human translation elongation factor eEF1H complex using the yeast two-hybrid system by Mansilla, Francisco, Friis, Irene, Jadidi, Mandana, Nielsen, Karen M, Clark, Brian F C, Knudsen, Charlotte R

“…In eukaryotes, the eukaryotic translation elongation factor eEF1A responsible for transporting amino-acylated tRNA to the ribosome forms a higher-order…”
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Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach by Negrutskii, Boris S, Porubleva, Larysa V, Malinowska, Agata, Novosylna, Oleksandra V, Dadlez, Michal, Knudsen, Charlotte R

“…Mammalian translation elongation factors eEF1A1 and eEF1A2 are 92% homologous isoforms whose mutually exclusive tissue-specific expression is regulated during…”
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Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome by Stapulionis, Romualdas, Wang, Yuhong, Dempsey, Graham T, Khudaravalli, Rama, Nielsen, Karen Margrethe, Cooperman, Barry S, Goldman, Yale E, Knudsen, Charlotte R

“…The ribosome is the macromolecular machine responsible for translating the genetic code into polypeptide chains. Despite impressive structural and kinetic…”
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Structure of the Qβ replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins by Kidmose, Rune T., Vasiliev, Nikita N., Chetverin, Alexander B., Andersen, Gregers Rom, Knudsen, Charlotte R., Darst, Seth A.

“…The RNA-dependent RNA polymerase core complex formed upon infection of Escherichia coli by the bacteriophage Qβ is composed of the viral catalytic β-subunit as…”
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Structural basis for RNA-genome recognition during bacteriophage Qβ replication by Gytz, Heidi, Mohr, Durita, Seweryn, Paulina, Yoshimura, Yuichi, Kutlubaeva, Zarina, Dolman, Fleur, Chelchessa, Bosene, Chetverin, Alexander B, Mulder, Frans A A, Brodersen, Ditlev E, Knudsen, Charlotte R

“…Upon infection of Escherichia coli by bacteriophage Qβ, the virus-encoded β-subunit recruits host translation elongation factors EF-Tu and EF-Ts and ribosomal…”
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Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca(2+)-ATPase 1 for Single-Molecule FRET Studies by Dyla, Mateusz, Andersen, Jacob Lauwring, Kjaergaard, Magnus, Birkedal, Victoria, Terry, Daniel S, Altman, Roger B, Blanchard, Scott C, Nissen, Poul, Knudsen, Charlotte R

“…Approximately 30% of the ATP generated in the living cell is utilized by P-type ATPase primary active transporters to generate and maintain electrochemical…”
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Novel Interaction between the M4 Muscarinic Acetylcholine Receptor and Elongation Factor 1A2 by McClatchy, Daniel B, Knudsen, Charlotte R, Clark, Brian F, Kahn, Richard A, Hall, Randy A, Levey, Allan I

“…The activation of the muscarinic acetylcholine receptor (mAChR) family, consisting of five subtypes (M 1 –M 5 ), produces a variety of physiological effects…”
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Kinetics of the Interactions between Yeast Elongation Factors 1A and 1Bα, Guanine Nucleotides, and Aminoacyl-tRNA by Gromadski, Kirill B., Schümmer, Tobias, Strømgaard, Anne, Knudsen, Charlotte R., Kinzy, Terri Goss, Rodnina, Marina V.

“…The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1Bα (eEF1Bα), guanine nucleotides, and aminoacyl-tRNA…”
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Labeled EF-Tus for Rapid Kinetic Studies of Pretranslocation Complex Formation by Liu, Wei, Kavaliauskas, Darius, Schrader, Jared M, Poruri, Kiran, Birkedal, Victoria, Goldman, Emanuel, Jakubowski, Hieronim, Mandecki, Wlodek, Uhlenbeck, Olke C, Knudsen, Charlotte R, Goldman, Yale E, Cooperman, Barry S

“…The universally conserved translation elongation factor EF-Tu delivers aminoacyl­(aa)-tRNA in the form of an aa-tRNA·EF-Tu·GTP ternary complex (TC) to the…”
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Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein by Mansilla, Francisco, Dominguez, Carlota A.G., Yeadon, James E., Corydon, Thomas J., Burden, Steven J., Knudsen, Charlotte R.

“…Eukaryotic translation elongation factor 1A (eEF1A) is a guanine‐nucleotide binding protein, which transports aminoacylated tRNA to the ribosomal A site during…”
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An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus by Dahl, Louise D, Corydon, Thomas J, Ränkel, Liina, Nielsen, Karen Margrethe, Füchtbauer, Ernst-Martin, Knudsen, Charlotte R

“…The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric…”
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Properties of Escherichia coli EF-Tu mutants designed for fluorescence resonance energy transfer from tRNA molecules by Perla-Kajan, Joanna, Lin, Xin, Cooperman, Barry S., Goldman, Emanuel, Jakubowski, Hieronim, Knudsen, Charlotte R., Mandecki, Wlodek

“…Here we describe the design, preparation and characterization of 10 EF-Tu mutants of potential utility for the study of Escherichia coli elongation factor Tu…”
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