Search Results - "Knowles, Sandra R."

Idiosyncratic drug reactions: the reactive metabolite syndromes by Knowles, Sandra R, Uetrecht, Jack, Shear, Neil H

“…Idiosyncratic drug reactions are unpredictable reactions that can result in significant morbidity and mortality. Severe idiosyncratic drug reactions are often…”
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Common Adverse Events Associated with the Use of Ribavirin for Severe Acute Respiratory Syndrome in Canada by Knowles, Sandra R., Phillips, Elizabeth J., Dresser, Linda, Matukas, Larissa

“…Although information on efficacy and adverse drug reactions is lacking, ribavirin has been used empirically for the treatment of severe acute respiratory…”
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Sulfonamide Hypersensitivity: Fact and Fiction by Khan, David A., Knowles, Sandra R., Shear, Neil H.

“…Sulfonamide antimicrobials are commonly reported as causing drug allergy and have been implicated in a variety of hypersensitivity reactions including…”
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Self-Monitoring of Blood Glucose: Impact of Quantity Limits in Public Drug Formularies on Provincial Costs Across Canada by Knowles, Sandra R., BScPhm, Lee, Kathy, MA, Paterson, J. Michael, MSc, Shah, Baiju R., MD, PhD, Mamdani, Muhammad M., PharmD, MA, MPH, Juurlink, David N., MD, PhD, Gomes, Tara, MHSc

“…Abstract Objectives For most patients with diabetes, routine use of blood glucose test strips (BGTS) has not been shown to be beneficial, yet the economic…”
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Recognition and Management of Severe Cutaneous Drug Reactions by Knowles, Sandra R., BScPhm, Shear, Neil H., MD, FRCPC, FACP

“…Cutaneous drug reactions are among the most common types of adverse drug reactions. This article focuses on the recognition and management of severe cutaneous…”
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Gender Differences in Adverse Drug Reactions by Tran, Chau, Knowles, Sandra R., Liu, Barbara A., Shear, Neil H.

“…The objective of this study is to identify gender‐related differences in the types of symptoms and drugs reported to cause an adverse drug reaction. Patient…”
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Incidence of Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome in an HIV Cohort: An Observational, Retrospective Case Series Study by Mittmann, Nicole, Knowles, Sandra R., Koo, Marika, Shear, Neil H., Rachlis, Anita, Rourke, Sean B.

“…Background : The incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been reported to be between 0.95 and 1 per 1000…”
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Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review by Tam, Vincent C, Knowles, Sandra R, Cornish, Patricia L, Fine, Nowell, Marchesano, Romina, Etchells, Edward E

“…Over a quarter of hospital prescribing errors are attributable to incomplete medication histories being obtained at the time of admission. We undertook a…”
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Immediate Hypersensitivity to Moxifloxacin with Tolerance to Ciprofloxacin: Report of Three Cases and Review of the Literature by Chang, Brenda, Knowles, Sandra R, Weber, Elizabeth

“…Objective To report 3 cases of immediate hypersensitivity reactions to moxifloxacin in patients who tolerated ciprofloxacin. Case summaries A 71-year-old man,…”
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Anticonvulsant hypersensitivity syndrome: an update by Knowles, Sandra R, Dewhurst, Norman, Shear, Neil H

“…Anticonvulsant hypersensitivity syndrome (AHS) is a rare but potentially life-threatening adverse drug reaction, primarily associated with phenytoin,…”
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Clinical and immunogenetic correlates of abacavir hypersensitivity by PHILLIPS, Elizabeth J, WONG, Gavin A, KAUL, Rupert, SHAHABI, Kamnoosh, NOLAN, David A, KNOWLES, Sandra R, MARTIN, Annalise M, MALLAL, Simon A, SHEAR, Neil H

“…A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS…”
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Patch Testing for the Diagnosis of Anticonvulsant Hypersensitivity Syndrome: A Systematic Review by Elzagallaai, Abdelbaset A., Knowles, Sandra R., Rieder, Michael J., Bend, John R., Shear, Neil H., Koren, Gideon

“…Anticonvulsant hypersensitivity syndrome (AHS), also known by the other names drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) and…”
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Immediate Hypersensitivity Reaction Induced by Metronidazole by Seto, Katherine, Knowles, Sandra R, Weber, Elizabeth A

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Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir by PHILLIPS, Elizabeth J, SULLIVAN, John R, KNOWLES, Sandra R, SHEAR, Neil H

“…A diagnostic test would be useful to help eliminate the associated morbidity and mortality after full-dose rechallenge with abacavir in patients with suspected…”
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Drug eruptions: approaching the diagnosis of drug-induced skin diseases by Nigen, Simon, Knowles, Sandra R, Shear, Neil H

“…Adverse drug reactions are a major problem in drug therapy, and cutaneous drug reactions account for a large proportion of all adverse drug reactions…”
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Unintended medication discrepancies at the time of hospital admission by Cornish, Patricia L, Knowles, Sandra R, Marchesano, Romina, Tam, Vincent, Shadowitz, Steven, Juurlink, David N, Etchells, Edward E

“…Prior studies suggest that unintended medication discrepancies that represent errors are common at the time of hospital admission. These errors are…”
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Evaluation of the extent of under-reporting of serious Adverse Drug reactions The case of Toxic epidermal necrolysis by MITTMANN, Nicole, KNOWLES, Snndra R, GOMEZ, Manuel, FISH, Joel S, CARTOTTO, Robert, SHEAR, Neil H

“…Toxic epidermal necrolysis (TEN) is a life-threatening adverse drug reaction (ADR) that is primarily the result of drug exposure (incidence 0.4-1.3 per million…”
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Povidone‐Iodine–Induced Burn: Case Report and Review of the Literature by Lowe, Donna O., Knowles, Sandra R., Weber, Elizabeth A., Railton, Craig J., Shear, Neil H.

“…Burns are a rare but potentially serious complication of povidone‐iodine use. This rare adverse drug reaction developed in a 38‐year‐old woman who underwent…”
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Incidence of Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome in an HIV Cohort by Mittmann, Nicole, Knowles, Sandra R, Koo, Marika, Shear, Neil H, Rachlis, Anita, Rourke, Sean B

“…Background: The incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been reported to be between 0.95 and 1 per 1000…”
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Sibutramine and Panic Attacks by BINKLEY, KAREN, KNOWLES, SANDRA R.

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