Search Results - "Knowles, R. R."

Developing an ecological approach to physical activity promotion in adults with Cystic fibrosis by Shelley, James, Dawson, Ellen A, Boddy, Lynne M, Stewart, Claire E, Frost, Freddy, Nazareth, Dilip, Walshaw, Martin J, Knowles, Zoe R

“…There are few examples of interventions designed to promote physical activity (PA) in adults with Cystic fibrosis (CF). Increasing levels of habitual PA may be…”
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Synthetic Applications of Proton-Coupled Electron Transfer by Gentry, Emily C, Knowles, Robert R

“…Redox events in which an electron and proton are exchanged in a concerted elementary step are commonly referred to as proton-coupled electron transfers…”
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Catalytic generation of alkoxy radicals from unfunctionalized alcohols by Tsui, Elaine, Wang, Huaiju, Knowles, Robert R

“…Alkoxy radicals have long been recognized as powerful synthetic intermediates with well-established reactivity patterns. Due to the high bond dissociation free…”
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Catalytic Alkene Carboaminations Enabled by Oxidative Proton-Coupled Electron Transfer by Choi, Gilbert J, Knowles, Robert R

“…Here we describe a dual catalyst system comprised of an iridium photocatalyst and weak phosphate base that is capable of both selectively homolyzing the N–H…”
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Ion-pair reorganization regulates reactivity in photoredox catalysts by Earley, J. D., Zieleniewska, A., Ripberger, H. H., Shin, N. Y., Lazorski, M. S., Mast, Z. J., Sayre, H. J., McCusker, J. K., Scholes, G. D., Knowles, R. R., Reid, O. G., Rumbles, G.

“…Cyclometalated and polypyridyl complexes of d 6 metals are promising photoredox catalysts, using light to drive reactions with high kinetic or thermodynamic…”
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A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C–C Bond Cleavage Reactions by Ota, Eisuke, Wang, Huaiju, Frye, Nils Lennart, Knowles, Robert R

“…We report a general protocol for the light-driven isomerization of cyclic aliphatic alcohols to linear carbonyl compounds. These reactions proceed via…”
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Catalytic alkylation of remote C–H bonds enabled by proton-coupled electron transfer by Choi, Gilbert J., Zhu, Qilei, Miller, David C., Gu, Carol J., Knowles, Robert R.

“…Catalytic alkylation of C–H bonds is achieved via homolysis of N–H bonds of N -alkyl amides through proton-coupled electron transfer. Functionalizing…”
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Light - driven deracemization enabled by excited - state electron transfer by Shin, Nick Y, Ryss, Jonathan M, Zhang, Xin, Miller, Scott J, Knowles, Robert R

“…Deracemization is an attractive strategy for asymmetric synthesis, but intrinsic energetic challenges have limited its development. Here, we report a…”
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Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O–H Bonds by Yayla, Hatice G, Wang, Huaiju, Tarantino, Kyle T, Orbe, Hudson S, Knowles, Robert R

“…We report a new photocatalytic protocol for the redox-neutral isomerization of cyclic alcohols to linear ketones via C–C bond scission. Mechanistic studies…”
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1,3‐Alkyl Transposition in Allylic Alcohols Enabled by Proton‐Coupled Electron Transfer by Zhao, Kuo, Seidler, Gesa, Knowles, Robert R.

“…A method is described for the isomerization of acyclic allylic alcohols into β‐functionalized ketones via 1,3‐alkyl transposition. This reaction proceeds via…”
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Enantioselective Synthesis of Pyrroloindolines via Noncovalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products by Gentry, Emily C, Rono, Lydia J, Hale, Martina E, Matsuura, Rei, Knowles, Robert R

“…While interest in the synthetic chemistry of radical cations continues to grow, controlling enantioselectivity in the reactions of these intermediates remains…”
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Attractive noncovalent interactions in asymmetric catalysis: Links between enzymes and small molecule catalysts by Knowles, Robert R., Jacobsen, Eric N., MacMillan, David W. C.

“…Catalysis by neutral, organic, small molecules capable of binding and activating substrates solely via noncovalent interactions—particularly H-bonding—has…”
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Catalytic Ketyl-Olefin Cyclizations Enabled by Proton-Coupled Electron Transfer by Tarantino, Kyle T, Liu, Peng, Knowles, Robert R

“…Concerted proton-coupled electron transfer is a key mechanism of substrate activation in biological redox catalysis. However, its applications in organic…”
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Catalytic Olefin Hydroamidation Enabled by Proton-Coupled Electron Transfer by Miller, David C, Choi, Gilbert J, Orbe, Hudson S, Knowles, Robert R

“…Here we report a ternary catalyst system for the intramolecular hydroamidation of unactivated olefins using simple N-aryl amide derivatives. Amide activation…”
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Photocatalytic Generation of Aminium Radical Cations for C─N Bond Formation by Ganley, Jacob M, Murray, Philip R D, Knowles, Robert R

“…Aminium radical cations have been extensively studied as electrophilic aminating species that readily participate in C─N bond forming processes with alkenes…”
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Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia by Lin, Jianfeng, Yin, Weining, Smith, Maria C., Song, Kangkang, Leigh, Margaret W., Zariwala, Maimoona A., Knowles, Michael R., Ostrowski, Lawrence E., Nicastro, Daniela

“…Cilia play essential roles in normal human development and health; cilia dysfunction results in diseases such as primary ciliary dyskinesia (PCD). Despite…”
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Catalytic Hydroetherification of Unactivated Alkenes Enabled by Proton‐Coupled Electron Transfer by Tsui, Elaine, Metrano, Anthony J., Tsuchiya, Yuto, Knowles, Robert R.

“…We report a catalytic, light‐driven method for the intramolecular hydroetherification of unactivated alkenols to furnish cyclic ether products. These reactions…”
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Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis by Murray, Philip R. D, Cox, James H, Chiappini, Nicholas D, Roos, Casey B, McLoughlin, Elizabeth A, Hejna, Benjamin G, Nguyen, Suong T, Ripberger, Hunter H, Ganley, Jacob M, Tsui, Elaine, Shin, Nick Y, Koronkiewicz, Brian, Qiu, Guanqi, Knowles, Robert R

“…We present here a review of the photochemical and electrochemical applications of multi-site proton-coupled electron transfer (MS-PCET) in organic synthesis…”
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Catalytic C–N Bond-Forming Reactions Enabled by Proton-Coupled Electron Transfer Activation of Amide N–H Bonds by Nguyen, Lucas Q, Knowles, Robert R

“…Over the past three years, our group has become interested in the ability of proton-coupled electron transfer (PCET) to facilitate direct homolytic bond…”
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C–H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C–H Bond by Morton, Carla M, Zhu, Qilei, Ripberger, Hunter, Troian-Gautier, Ludovic, Toa, Zi S. D, Knowles, Robert R, Alexanian, Erik J

“…The direct, site-selective alkylation of unactivated C­(sp3)–H bonds in organic substrates is a long-standing goal in synthetic chemistry. General approaches…”
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