Search Results - "Knowles, M. M."

Advances in Immuno–Positron Emission Tomography: Antibodies for Molecular Imaging in Oncology by KNOWLES, Scott M, WU, Anna M

“…Identification of cancer cell-surface biomarkers and advances in antibody engineering have led to a sharp increase in the development of therapeutic…”
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FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer by Tomlinson, DC, Baldo, O, Harnden, P, Knowles, MA

“…FGFR3 is frequently activated by mutation in urothelial carcinoma (UC) and represents a potential target for therapy. In multiple myeloma, both over-expression…”
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Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo by Lamont, F R, Tomlinson, D C, Cooper, P A, Shnyder, S D, Chester, J D, Knowles, M A

“…Background: Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are…”
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Mechanisms of FGFR3 actions in endocrine resistant breast cancer by Tomlinson, D.C., Knowles, M.A., Speirs, V.

“…Although endocrine therapy has dramatically improved the treatment of breast cancer therapeutic resistance and tumour recurrence occurs, even in estrogen…”
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The Directional Dependence of Elastic Stiffness and Compliance Shear Coefficients and Shear Moduli in Cubic Materials by Knowles, Kevin M., Howie, Philip R.

“…The mathematics associated with the representation surfaces for elastic stiffness and compliance shear coefficients and shear moduli for planes in the standard…”
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Engineered antibody fragments for immuno-PET imaging of endogenous CD8⁺ T cells in vivo by Tavaré, Richard, McCracken, Melissa N., Zettlitz, Kirstin A., Knowles, Scott M., Salazar, Felix B., Olafsen, Tove, Witte, Owen N., Wu, Anna M.

“…The noninvasive detection and quantification of CD8 ⁺ T cells in vivo are important for both the detection and staging of CD8 ⁺ lymphomas and for the…”
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The phylogeography of Myotis bat-associated rabies viruses across Canada by Nadin-Davis, Susan, Alnabelseya, Noor, Knowles, M Kimberly

“…As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of…”
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Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner by di Martino, E, L'Hôte, C G, Kennedy, W, Tomlinson, D C, Knowles, M A

“…Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific…”
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Multi‐Stage Evolution of the South Australian Craton: Petrological Constraints on the Architecture, Lithology, and Geochemistry of the Lithospheric Mantle by Sudholz, Z. J., Yaxley, G. M., Jaques, A. L., Cooper, S. A., Czarnota, K., Taylor, W. R., Chen, J., Knowles, B. M.

“…To improve the understanding of the formation and evolution of the sub‐continental lithospheric mantle (SCLM) underlying the South Australian Craton we have…”
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Generalized Theory and Realization of Continuously Loss-Programmable Bandpass Filtering Attenuators by Knowles, Jonathan M., Sigmarsson, Hjalti H., McDaniel, Jay W.

“…In this article, a generalized theory of bandpass filtering attenuators (filtenuators) is proposed. A filtenuator is a device that combines the…”
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Single Dose of the Attention Training Technique Increases Resting Alpha and Beta-Oscillations in Frontoparietal Brain Networks: A Randomized Controlled Comparison by Knowles, Mark M, Wells, Adrian

“…The Attention Training Technique (ATT) was developed with the aim of reducing self-focused attention and increasing executive control as part of metacognitive…”
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Spatial memory and stereotypy of flight paths by big brown bats in cluttered surroundings by Barchi, Jonathan R, Knowles, Jeffrey M, Simmons, James A

“…The big brown bat, Eptesicus fuscus, uses echolocation for foraging and orientation. The limited operating range of biosonar implies that bats must rely upon…”
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CCA1 and ELF3 Interact in the Control of Hypocotyl Length and Flowering Time in Arabidopsis by Lu, Sheen X., Webb, Candace J., Knowles, Stephen M., Kim, Sally H.J., Wang, Zhiyong, Tobin, Elaine M.

“…The circadian clock is an endogenous oscillator with a period of approximately 24 h that allows organisms to anticipate, and respond to, changes in the…”
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Outcome of Deferred Initial Therapy in Mantle-Cell Lymphoma by MARTIN, Peter, CHADBURN, Amy, MELNICK, Ari, KNOWLES, Daniel M, CHEN-KIANG, Selina, COLEMAN, Morton, LEONARD, John P, CHRISTOS, Paul, WEIL, Karen, FURMAN, Richard R, JIA RUAN, ELSTROM, Rebecca, NIESVIZKY, Ruben, ELY, Scott, DILIBERTO, Maurizio

“…Treatment of mantle-cell lymphoma (MCL) is nonstandardized, though patients are commonly treated immediately at diagnosis. Because data on observation, or…”
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Syntaxin clusters assemble reversibly at sites of secretory granules in live cells by Barg, S., Knowles, M. K., Chen, X., Midorikawa, M., Almers, Wolfhard

“…Syntaxin resides in the plasma membrane, where it helps to catalyze membrane fusion during exocytosis. The protein also forms clusters in cell-free and…”
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CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL Function Synergistically in the Circadian Clock of Arabidopsis by Lu, Sheen X, Knowles, Stephen M, Andronis, Christos, Ong, May S, Tobin, Elaine M

“…The circadian clock is an endogenous mechanism that coordinates biological processes with daily and seasonal changes in the environment. Heterodimerization of…”
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Micro-machining of metals, ceramics and polymers using nanosecond lasers by Knowles, M. R. H., Rutterford, G., Karnakis, D., Ferguson, A.

“…Laser micro-processing is an enabling technology that facilitates component miniaturisation and improved performance characteristics. It is being applied…”
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Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers by Knowles, M. K., Barg, S., Wan, L., Midorikawa, M., Chen, X., Almers, Wolfhard

“…Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma…”
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Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer by Blick, C, Ramachandran, A, Wigfield, S, McCormick, R, Jubb, A, Buffa, F M, Turley, H, Knowles, M A, Cranston, D, Catto, J, Harris, A L

“…Background: Non-muscle invasive (NMI) bladder cancer is characterised by increased expression and activating mutations of FGFR3. We have previously…”
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ETV5 as a mediator of the oncogenic effects of mutant FGFR3 in bladder cancer by Di Martino, E, Knowles, M

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