Search Results - "Knowler, W. C."

The Effect of Lifestyle Intervention and Metformin on Preventing or Delaying Diabetes Among Women With and Without Gestational Diabetes: The Diabetes Prevention Program Outcomes Study 10-Year Follow-Up by Aroda, V. R, Christophi, C. A, Edelstein, S. L, Zhang, P, Herman, W. H, Barrett-Connor, E, Delahanty, L. M, Montez, M. G, Ackermann, R. T, Zhuo, X, Knowler, W. C, Ratner, R. E, for the Diabetes Prevention Program Research Group

“…Context: Gestational diabetes (GDM) confers a high risk of type 2 diabetes. In the Diabetes Prevention Program (DPP), intensive lifestyle (ILS) and metformin…”
Get full text

Development, validation and use of an insulin sensitivity score in youths with diabetes: the SEARCH for Diabetes in Youth study by Dabelea, D, D'Agostino, R. B. Jr, Mason, C. C, West, N, Hamman, R. F, Mayer-Davis, E. J, Maahs, D, Klingensmith, G, Knowler, W. C, Nadeau, K

“…Aims/hypothesis The ability to measure insulin sensitivity across the phenotypic spectrum of diabetes may contribute to a more accurate characterisation of…”
Get full text

Steroid Sex Hormones, Sex Hormone–Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program by Mather, K. J, Kim, C, Christophi, C. A, Aroda, V. R, Knowler, W. C, Edelstein, S. E, Florez, J. C, Labrie, F, Kahn, S. E, Goldberg, R. B, Barrett-Connor, E

“…Context: Steroid sex hormones and SHBG may modify metabolism and diabetes risk, with implications for sex-specific diabetes risk and effects of prevention…”
Get full text

Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program by Franks, P. W, Jablonski, K. A, Delahanty, L. M, McAteer, J. B, Kahn, S. E, Knowler, W. C, Florez, J. C

“…Aims/hypothesis The single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity associated gene (FTO) and the rs7566605 SNP located 10 kb…”
Get full text

FTO predicts weight regain in the Look AHEAD clinical trial by McCaffery, J M, Papandonatos, G D, Huggins, G S, Peter, I, Kahn, S E, Knowler, W C, Hudnall, G E, Lipkin, E W, Kitabchi, A E, Wagenknecht, L E, Wing, R R

“…Background: Genome-wide association studies have provided new insights into the genetic factors that contribute to the development of obesity. We hypothesized…”
Get full text

The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes by GABIR, M. M, HANSON, R. L, DABELEA, D, IMPERATORE, G, ROUMAIN, J, BENNETT, P. H, KNOWLER, W. C

“…The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. M M Gabir , R…”
Get full text

First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes by Venditti, E.M, Bray, G.A, Carrion-Petersen, M.L, Delahanty, L.M, Edelstein, S.L, Hamman, R.F, Hoskin, M.A, Knowler, W.C, Ma, Y

“…Objective: Following unblinding of the Diabetes Prevention Program (DPP) results, a 16-session lifestyle intervention program was offered to all study…”
Get full text

Increasing prevalence of Type II diabetes in American Indian children by DABELEA, D, HANSON, R. L, BENNETT, P. H, ROUMAIN, J, KNOWLER, W. C, PETTITT, D. J

“…Until recently, Type II diabetes was considered rare in children. The disease is, however, increasing among children in populations with high rates of Type II…”
Get full text

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program by Florez, J. C, Jablonski, K. A, McAteer, J, Sandhu, M. S, Wareham, N. J, Barroso, I, Franks, P. W, Altshuler, D, Knowler, W. C

“…Aims/hypothesis Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single…”
Get full text

Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes by Rubin, R. R, Gaussoin, S. A, Peyrot, M, DiLillo, V, Miller, K, Wadden, T. A, West, D. S, Wing, R. R, Knowler, W. C

“…Aims/hypothesis To determine the associations of baseline depression symptoms and use of antidepressant medicines (ADMs) with baseline cardiovascular disease…”
Get full text

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program by Mather, K. J., Christophi, C. A., Jablonski, K. A., Knowler, W. C., Goldberg, R. B., Kahn, S. E., Spector, T., Dastani, Z., Waterworth, D., Richards, J. B., Funahashi, T., Pi-Sunyer, F. X., Pollin, T. I., Florez, J. C., Franks, P. W.

“…Diabet. Med. 29, 1579–1588 (2012) Aims  Baseline adiponectin concentrations predict incident Type 2 diabetes mellitus in the Diabetes Prevention Program. We…”
Get full text

Diabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program by Dabelea, D., Ma, Y., Knowler, W. C., Marcovina, S., Saudek, C. D., Arakaki, R., White, N. H., Kahn, S. E., Orchard, T. J., Goldberg, R., Palmer, J., Hamman, R. F.

“…Aims To determine if the presence of diabetes autoantibodies predicts the development of diabetes among participants in the Diabetes Prevention Program…”
Get full text

Pro12Ala variant at the peroxisome proliferator-activated receptor γ gene and change in obesity-related traits in the Diabetes Prevention Program by Franks, P. W, Jablonski, K. A, Delahanty, L, Hanson, R. L, Kahn, S. E, Altshuler, D, Knowler, W. C, Florez, J. C

“…Aims/hypothesis Peroxisome proliferator-activated receptor γ (PPARγ), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind…”
Get full text

Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships by DABELEA, Dana, HANSON, Robert L, LINDSAY, Robert S, PETTITT, David J, IMPERATORE, Giuseppina, GABIR, Momin M, ROUMAIN, Janine, BENNETT, Peter H, KNOWLER, William C

“…Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. D Dabelea , R L Hanson , R S Lindsay , D J…”
Get full text

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians by Bian, L, Hanson, R. L, Muller, Y. L, Ma, L, Kobes, S, Knowler, W. C, Bogardus, C, Baier, L. J

“…Aims/hypothesis A prior genome-wide association study in Pima Indians identified a variant within the ACAD10 gene that is associated with early-onset type 2…”
Get full text

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion by Williams, R. C., Muller, Y. L., Hanson, R. L., Knowler, W. C., Mason, C. C., Bian, L., Ossowski, V., Wiedrich, K., Chen, Y. F., Marcovina, S., Hahnke, J., Nelson, R. G., Baier, L. J., Bogardus, C.

“…Aims/hypothesis We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona…”
Get full text

Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes by LOOKER, H. C, FAGOT-CAMPAGNA, A, GUNTER, E. W, PFEIFFER, C. M, VENKAT NARAYAN, K. M, KNOWLER, W. C, HANSON, R. L

“…The aim of this study was to examine the relation between serum total homocysteine concentrations and microvascular complications in Pima Indians with Type 2…”
Get full text

Cost of intervention delivery in a lifestyle weight loss trial in type 2 diabetes: results from the Look AHEAD clinical trial by Rushing, J., Wing, R., Wadden, T. A., Knowler, W. C., Lawlor, M., Evans, M., Killean, T., Montez, M., Espeland, M. A., Zhang, P.

“…Summary Objective The Action for Health in Diabetes (Look AHEAD) trial was a randomized controlled clinical trial to compare the effects of 10 years of…”
Get full text

Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians by Pavkov, M.E., Knowler, W.C., Bennett, P.H., Looker, H.C., Krakoff, J., Nelson, R.G.

“…The introduction of more efficacious treatments for diabetic kidney disease may slow its progression, but evidence for their effectiveness in populations is…”
Get full text

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus by The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

“…Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus The Expert Committee on the Diagnosis and Classification of Diabetes…”
Get full text