Search Results - "Knotts, Trina A."

Acylcarnitines—old actors auditioning for new roles in metabolic physiology by McCoin, Colin S., Knotts, Trina A., Adams, Sean H.

“…Key Points Long-chain acylcarnitines (LCACs) are lipid derivatives generated from carnitine by mitochondrial carnitine O-palmitoyltransferase 1 or through the…”
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Acylcarnitines activate proinflammatory signaling pathways by Rutkowsky, Jennifer M, Knotts, Trina A, Ono-Moore, Kikumi D, McCoin, Colin S, Huang, Shurong, Schneider, Dina, Singh, Shamsher, Adams, Sean H, Hwang, Daniel H

“…Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that…”
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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice by Holland, William L, Bikman, Benjamin T, Wang, Li-Ping, Yuguang, Guan, Sargent, Katherine M, Bulchand, Sarada, Knotts, Trina A, Shui, Guanghou, Clegg, Deborah J, Wenk, Markus R, Pagliassotti, Michael J, Scherer, Philipp E, Summers, Scott A

“…Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and…”
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Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet by Rutkowsky, Jennifer M, Lee, Linda L, Puchowicz, Michelle, Golub, Mari S, Befroy, Douglas E, Wilson, Dennis W, Anderson, Steven, Cline, Gary, Bini, Jason, Borkowski, Kamil, Knotts, Trina A, Rutledge, John C

“…Recent work suggests that diet affects brain metabolism thereby impacting cognitive function. Our objective was to determine if a western diet altered brain…”
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Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance by Holland, William L., Brozinick, Joseph T., Wang, Li-Ping, Hawkins, Eric D., Sargent, Katherine M., Liu, Yanqi, Narra, Krishna, Hoehn, Kyle L., Knotts, Trina A., Siesky, Angela, Nelson, Don H., Karathanasis, Sotirios K., Fontenot, Greg K., Birnbaum, Morris J., Summers, Scott A.

“…Insulin resistance occurs in 20%–25% of the human population, and the condition is a chief component of type 2 diabetes mellitus and a risk factor for…”
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Sex‐specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia‐susceptible mice by Rutkowsky, Jennifer M., Knotts, Trina A., Allen, Paul D., Pessah, Isaac N., Ramsey, Jon J.

“…Malignant hyperthermia (MH) is characterized by induction of skeletal muscle hyperthermia in response to a dysregulated increase in myoplasmic calcium…”
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Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism by Goodson, Michael L, Knotts, Trina A, Campbell, Elsie L, Snyder, Chelsea A, Young, Briana M, Privalsky, Martin L

“…The NCoR corepressor plays critical roles in mediating transcriptional repression by both nuclear receptors and non-receptor transcription factors. Alternative…”
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Metabolic Responses to Butyrate Supplementation in LF- and HF-Fed Mice Are Cohort-Dependent and Associated with Changes in Composition and Function of the Gut Microbiota by Lee, Sunhye, Knotts, Trina A, Goodson, Michael L, Barboza, Mariana, Wudeck, Elyse, England, Grace, Raybould, Helen E

“…The gut microbiota and associated metabolites have emerged as potential modulators of pathophysiological changes in obesity and related metabolic disorders…”
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A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids by Chavez, Jose Antonio, Knotts, Trina A, Wang, Li-Ping, Li, Guibin, Dobrowsky, Rick T, Florant, Gregory L, Summers, Scott A

“…Multiple studies suggest that lipid oversupply to skeletal muscle contributes to the development of insulin resistance, perhaps by promoting the accumulation…”
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Evaluation of the synuclein-γ (SNCG) gene as a PPARγ target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue by Dunn, Tamara N, Akiyama, Tasuku, Lee, Hyun Woo, Kim, Jae Bum, Knotts, Trina A, Smith, Steven R, Sears, Dorothy D, Carstens, Earl, Adams, Sean H

“…Recent evidence in adipocytes points to a role for synuclein-γ in metabolism and lipid droplet dynamics, but interestingly this factor is also robustly…”
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Conservation Implications of Shifting Gut Microbiomes in Captive-Reared Endangered Voles Intended for Reintroduction into the Wild by Allan, Nora, Knotts, Trina A, Pesapane, Risa, Ramsey, Jon J, Castle, Stephanie, Clifford, Deana, Foley, Janet

“…The Amargosa vole is a highly endangered rodent endemic to a small stretch of the Amargosa River basin in Inyo County, California. It specializes on a single,…”
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Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders by McCoin, Colin S., Gillingham, Melanie B., Knotts, Trina A., Vockley, Jerry, Ono‐Moore, Kikumi D., Blackburn, Michael L., Norman, Jennifer E., Adams, Sean H.

“…Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and…”
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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice by Roberts, Megan N., Wallace, Marita A., Tomilov, Alexey A., Zhou, Zeyu, Marcotte, George R., Tran, Dianna, Perez, Gabriella, Gutierrez-Casado, Elena, Koike, Shinichiro, Knotts, Trina A., Imai, Denise M., Griffey, Stephen M., Kim, Kyoungmi, Hagopian, Kevork, McMackin, Marissa Z., Haj, Fawaz G., Baar, Keith, Cortopassi, Gino A., Ramsey, Jon J., Lopez-Dominguez, Jose Alberto

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Sex differences in response to short-term high fat diet in mice by Huang, Kuei-Pin, Ronveaux, Charlotte C., Knotts, Trina A., Rutkowsky, Jennifer R., Ramsey, Jon J., Raybould, Helen E.

“…•Male mice are more susceptible to short-term HF-induced weight gain than female mice.•HF-fed male mice have less physical activity, accompanied with lower…”
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Acylcarnitines: potential implications for skeletal muscle insulin resistance by Aguer, Céline, McCoin, Colin S., Knotts, Trina A., Thrush, A. Brianne, Ono‐Moore, Kikumi, McPherson, Ruth, Dent, Robert, Hwang, Daniel H., Adams, Sean H., Harper, Mary‐Ellen

“…Insulin resistance may be linked to incomplete fatty acid β‐oxidation and the subsequent increase in acylcarnitine species in different tissues including…”
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Myelin as a regulator of development of the microbiota-gut-brain axis by Keogh, Ciara E., Kim, Danielle H.J., Pusceddu, Matteo M., Knotts, Trina A., Rabasa, Gonzalo, Sladek, Jessica A., Hsieh, Michael T., Honeycutt, Mackenzie, Brust-Mascher, Ingrid, Barboza, Mariana, Gareau, Mélanie G.

“…•Neonatal antibiotics (Abx) causes gut dysbiosis and pathophysiology in adult mice.•Early Abx administration causes behavioral impairments in…”
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Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons by Oort, Pieter J., Warden, Craig H., Baumann, Thomas K., Knotts, Trina A., Adams, Sean H.

“…Tumor suppressor candidate 5 (Tusc5, also termed brain endothelial cell derived gene-1 or BEC-1), a CD225 domain-containing, cold-repressed gene identified…”
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Region-Specific Cell Membrane N-Glycome of Functional Mouse Brain Areas Revealed by nanoLC-MS Analysis by Barboza, Mariana, Solakyildirim, Kemal, Knotts, Trina A., Luke, Jonathan, Gareau, Melanie G., Raybould, Helen E., Lebrilla, Carlito B.

“…N-glycosylation is a ubiquitous posttranslational modification that affects protein structure and function, including those of the central nervous system…”
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A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood by Salvo, Eloisa, Stokes, Patricia, Keogh, Ciara E, Brust-Mascher, Ingrid, Hennessey, Carly, Knotts, Trina A, Sladek, Jessica A, Rude, Kavi M, Swedek, Michelle, Rabasa, Gonzalo, Gareau, Mélanie G

“…Inflammatory bowel diseases (IBDs) are chronic intestinal diseases, frequently associated with comorbid psychological and cognitive deficits. These…”
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Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial by Piccolo, Brian D, Comerford, Kevin B, Karakas, Sidika E, Knotts, Trina A, Fiehn, Oliver, Adams, Sean H

“…It has been suggested that perturbations in branched-chain amino acid (BCAA) catabolism are associated with insulin resistance and contribute to elevated…”
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