Search Results - "Knott, Aine"

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma by Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

“…Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data…”
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ERK Inhibitor LY3214996-Based Treatment Strategies for RAS -Driven Lung Cancer by Köhler, Jens, Zhao, Yutong, Li, Jiaqi, Gokhale, Prafulla C, Tiv, Hong L, Knott, Aine R, Wilkens, Margaret K, Soroko, Kara M, Lin, Mika, Ambrogio, Chiara, Musteanu, Monica, Ogino, Atsuko, Choi, Jihyun, Bahcall, Magda, Bertram, Arrien A, Chambers, Emily S, Paweletz, Cloud P, Bhagwat, Shripad V, Manro, Jason R, Tiu, Ramon V, Jänne, Pasi A

“…gene mutations are the most frequent oncogenic event in lung cancer. They activate multiple RAS-centric signaling networks among them the MAPK, PI3K, and RB…”
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Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM) by Lapidot, Moshe, Case, Abigail E., Weisberg, Ellen L., Meng, Chengcheng, Walker, Sarah R., Garg, Swati, Ni, Wei, Podar, Klaus, Hung, Yin P., Carrasco, Ruben D., Knott, Aine, Gokhale, Prafulla C., Sharma, Sunil, Pozhitkov, Alex, Kulkarni, Prakash, Frank, David A., Salgia, Ravi, Griffin, James D., Saladi, Srinivas V., Bueno, Raphael, Sattler, Martin

“…Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin…”
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Developing SHP2-based combination therapy for KRAS-amplified cancer by Li, Tianxia, Kikuchi, Osamu, Zhou, Jin, Wang, Yichen, Pokharel, Babita, Bastl, Klavdija, Gokhale, Prafulla, Knott, Aine, Zhang, Yanxi, Doench, John G, Ho, Zandra V, Catenacci, Daniel Vt, Bass, Adam J

“…Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression of WT KRAS protein. We previously demonstrated…”
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Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma by Ananthapadmanabhan, Varsha, Frost, Thomas C, Soroko, Kara M, Knott, Aine, Magliozzi, Brianna J, Gokhale, Prafulla C, Tirunagaru, Vijaya G, Doebele, Robert C, DeCaprio, James A

“…Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in…”
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Abstract P203: Milademetan is a potent, murine double minute 2 (MDM2) inhibitor, highly active in TP53 wild-type (p53WT) Merkel cell carcinoma (MCC) cell lines by Ananthapadmanabhan, Varsha, Knott, Aine, Soroko, Kara M., Gokhale, Prafulla C., Tirunagaru, Vijaya, Doebele, Robert, DeCaprio, James A.

“…Abstract Background: MCC is a highly aggressive neuroendocrine carcinoma of the skin with a poor overall prognosis. Current treatment options include surgery…”
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Milademetan is a highly potent MDM2 inhibitor in TP53 wild-type (p53 WT) models of Merkel cell carcinoma (MCC) by Ananthapadmanabhan, Varsha, Frost, Thomas C., Soroko, Kara M., Knott, Aine, Magliozzi, Brianna, Gokhale, Prafulla C., Tirunagaru, Vijaya, Doebele, Robert C., DeCaprio, James A.

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Abstract C020: Unconvering the hidden immunosuppressive landscape in pancreatic ductal adenocarcinoma by Qian, Guhan, Zhang, Hongrong, Knott, Aine, Zettervall, Jon, Stromnes, Ingunn, Provenzano, Paolo

“…Abstract Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest forms of cancer with an extremely low survival rate. Despite the success of therapeutic…”
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IMMU-09. CONCURRENT DEXAMETHASONE LIMITS THE CLINICAL BENEFIT OF IMMUNE CHECKPOINT BLOCKADE IN GLIOBLASTOMA by Iorgulescu, Bryan, Gokhale, Prafulla, Speranza, Maria, Eschle, Benjamin, Poitras, Michael, Wilkens, Margaret, Soroko, Kara, Chhoeu, Chhayheng, Knott, Aine, Gao, Yang, Lim-Fat, Mary Jane, Baker, Gregory, Bonal, Dennis, Nguyen, Quang-De, Grant, Gareth, Ligon, Keith, Sorger, Peter, Chiocca, E Antonio, Anderson, Ana, Kirschmeier, Paul, Sharpe, Arlene, Freeman, Gordon, Reardon, David

“…Abstract BACKGROUND Dexamethasone, a uniquely potent corticosteroid, is frequently administered to brain tumor patients to decrease tumor-associated edema, but…”
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Abstract 6377: Developing combination therapy with SHP2 inhibition for CIN-type gastroesophageal adenocarcinoma with KRAS amplification by Kikuchi, Osamu, Li, Tianxia, Zhou, Jin, Wang, Yichen, Bastl, Klavdija, Gokhale, Prafulla C., Knott, Aine, Zhang, Yanxi, Doench, John G., Ho, Zandra, Catenacci, Daniel V., Bass, Adam J.

“…Abstract Recent studies from the cancer genome atlas (TCGA. Nature. 2014) (TCGA. Nature. 2017) and other groups showed that a molecular subtype with…”
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