Search Results - "Knothe, Claudia"

Olfactory drug effects approached from human-derived data by Lötsch, Jörn, Knothe, Claudia, Lippmann, Catharina, Ultsch, Alfred, Hummel, Thomas, Walter, Carmen

“…•Recognition of the role olfaction in human life renders olfactory drug effects important.•Evidence on olfactory effects includes 71 drugs; seven from…”
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The impact of endurance exercise on global and AMPK gene-specific DNA methylation by King-Himmelreich, Tanya S., Schramm, Stefanie, Wolters, Miriam C., Schmetzer, Julia, Möser, Christine V., Knothe, Claudia, Resch, Eduard, Peil, Johannes, Geisslinger, Gerd, Niederberger, Ellen

“…Alterations in gene expression as a consequence of physical exercise are frequently described. The mechanism of these regulations might depend on epigenetic…”
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Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: Post-hoc analyses of the phase II adrenomedullin and outcome in septic shock 2 trial by van Lier, Dirk, Picod, Adrien, Marx, Gernot, Laterre, Pierre-François, Hartmann, Oliver, Knothe, Claudia, Azibani, Feriel, Struck, Joachim, Santos, Karine, Zimmerman, Jens, Bergmann, Andreas, Mebazaa, Alexandre, Pickkers, Peter

“…Adrecizumab, a non-neutralizing antibody of adrenomedullin (ADM) was recently investigated regarding its potential to restore endothelial barrier function in…”
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High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion by Shiratori, Hiromi, Feinweber, Carmen, Knothe, Claudia, Lötsch, Jörn, Thomas, Dominique, Geisslinger, Gerd, Parnham, Michael J, Resch, Eduard

“…DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is associated with various diseases including cancer. Many…”
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AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs by King, Tanya S., Russe, Otto Quintus, Möser, Christine V., Ferreirós, Nerea, Kynast, Katharina L., Knothe, Claudia, Olbrich, Katrin, Geisslinger, Gerd, Niederberger, Ellen

“…AMP-activated kinase (AMPK) is a cellular energy sensor, which is activated in stages of increased adenosine triphosphate (ATP) consumption. Its activation has…”
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Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations by Walter, Carmen, Knothe, Claudia, Lötsch, Jörn

“…Abuse-deterrent formulations (ADFs) are technologically sophisticated pharmaceutical formulations that impede manipulation and extraction of opioids and/or…”
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Methadone induces hypermethylation of human DNA by Knothe, Claudia, Doehring, Alexandra, Ultsch, Alfred, Lötsch, Jörn

“…: Increased global DNA methylation in the blood of patients chronically exposed to opioids had been interpreted as an indication of an epigenetic action of…”
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Olfactory drug effects approached from human-derived data: Post-screen by Lotsch, Jorn, Knothe, Claudia, Lippmann, Catharina, Ultsch, Alfred, Hummel, Thomas, Walter, Carmen

“…The complexity of the sense of smell makes adverse olfactory effects of drugs highly likely, which can impact a patient's quality of life. Here, we present a…”
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Disagreement between two common biomarkers of global DNA methylation by Knothe, Claudia, Shiratori, Hiromi, Resch, Eduard, Ultsch, Alfred, Geisslinger, Gerd, Doehring, Alexandra, Lötsch, Jörn

“…The quantification of global DNA methylation has been established in epigenetic screening. As more practicable alternatives to the HPLC-based gold standard,…”
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Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions by Knothe, Claudia, Oertel, Bruno G, Ultsch, Alfred, Kettner, Mattias, Schmidt, Peter Harald, Wunder, Cora, Toennes, Stefan W, Geisslinger, Gerd, Lötsch, Jörn

“…Exposure to opioids has been associated with epigenetic effects. Studies in rodents suggested a role of varying degrees of DNA methylation in the differential…”
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