Search Results - "Knorre, A. A"
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Intracellular quality control of mitochondrial DNA: evidence and limitations
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (20-01-2020)“…Eukaryotic cells can harbour mitochondria with markedly different transmembrane potentials. Intracellular mitochondrial quality-control mechanisms (e.g…”
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Mitochondrial heteroplasmy as a cause of cell-to-cell phenotypic heterogeneity in clonal populations
Published in Frontiers in cell and developmental biology (09-10-2023)Get full text
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Spontaneous Mutations in Saccharomyces cerevisiae mtDNA Increase Cell-to-Cell Variation in mtDNA Amount
Published in International journal of molecular sciences (12-12-2023)“…In a eukaryotic cell, the ratio of mitochondrial DNA (mtDNA) to nuclear DNA (nDNA) is usually maintained within a specific range. This suggests the presence of…”
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Forests synchronize their growth in contrasting Eurasian regions in response to climate warming
Published in Proceedings of the National Academy of Sciences - PNAS (19-01-2016)“…Forests play a key role in the carbon balance of terrestrial ecosystems. One of the main uncertainties in global change predictions lies in how the…”
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Long-term ecological consequences of forest fires in the continuous permafrost zone of Siberia
Published in Environmental research letters (01-03-2020)“…Wildfires are an important factor in controlling forest ecosystem dynamics across the circumpolar boreal zone. An improved understanding of their direct and…”
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Tyrosol induces multiple drug resistance in yeast Saccharomyces cerevisiae
Published in Frontiers in microbiology (05-06-2023)“…In yeast, multiple (pleiotropic) drug resistance (MDR) transporters efflux xenobiotics from the cytoplasm to the environment. Additionally, upon the…”
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Mitoptosis, Twenty Years After
Published in Biochemistry (Moscow) (01-12-2020)“…In 1999 V. P. Skulachev proposed the term “mitoptosis” to refer to the programmed elimination of mitochondria in living cells. According to the initial…”
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Replicative aging as a source of cell heterogeneity in budding yeast
Published in Mechanisms of ageing and development (01-12-2018)“…•Sequential rounds of asymmetric division cause microbial heterogeneity.•Increased phenotypic variance can be beneficial under stressful conditions.•Microbial…”
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Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA
Published in Journal of cell science (01-04-2017)“…Non-identical copies of mitochondrial DNA (mtDNA) compete with each other within a cell and the ultimate variant of mtDNA present depends on their relative…”
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Heterogeneity of Starved Yeast Cells in IF1 Levels Suggests the Role of This Protein in vivo
Published in Frontiers in microbiology (23-03-2022)“…In mitochondria, a small protein IF 1 suppresses the hydrolytic activity of ATP synthase and presumably prevents excessive ATP hydrolysis under conditions of…”
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Mitochondrial Superoxide Dismutase and Yap1p Act as a Signaling Module Contributing to Ethanol Tolerance of the Yeast Saccharomyces cerevisiae
Published in Applied and environmental microbiology (01-02-2017)“…There are two superoxide dismutases in the yeast Saccharomyces cerevisiae-cytoplasmic and mitochondrial enzymes. Inactivation of the cytoplasmic enzyme, Sod1p,…”
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Do Multiple Drug Resistance Transporters Interfere with Cell Functioning under Normal Conditions?
Published in Biochemistry (Moscow) (01-12-2020)“…Eukaryotic cells rely on multiple mechanisms to protect themselves from exogenous toxic compounds. For instance, cells can limit penetration of toxic molecules…”
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Secondary structure of the human mitochondrial genome affects formation of deletions
Published in BMC biology (08-05-2023)“…Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions…”
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Penetrating cations induce pleiotropic drug resistance in yeast
Published in Scientific reports (25-05-2018)“…Substrates of pleiotropic drug resistance (PDR) transporters can induce the expression of corresponding transporter genes by binding to their transcription…”
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Structural Role of Plasma Membrane Sterols in Osmotic Stress Tolerance of Yeast Saccharomyces cerevisiae
Published in Membranes (Basel) (17-12-2022)“…Yeast has been shown to suppress a sterol biosynthesis as a response to hyperosmotic stress. In the case of sodium stress, the failure to suppress biosynthesis…”
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Increasing drought effects on five European pines modulate Δ13C‐growth coupling along a Mediterranean altitudinal gradient
Published in Functional ecology (01-07-2017)“…Summary Climate warming increases vulnerability to drought in Mediterranean water‐limited forests. However, we still lack knowledge of the long‐term…”
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Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast
Published in The Journal of cell biology (17-01-2005)“…Although programmed cell death (PCD) is extensively studied in multicellular organisms, in recent years it has been shown that a unicellular organism, yeast…”
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LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles
Published in Frontiers in microbiology (28-01-2020)“…Lam proteins transport sterols between the membranes of different cellular compartments. In the gene family consists of three pairs of paralogs. Because the…”
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Coding palindromes in mitochondrial genes of Nematomorpha
Published in Nucleic acids research (26-07-2019)“…Inverted repeats are common DNA elements, but they rarely overlap with protein-coding sequences due to the ensuing conflict with the structure and function of…”
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Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers
Published in The Journal of biological chemistry (20-05-2011)“…A limited decrease in mitochondrial membrane potential can be beneficial for cells, especially under some pathological conditions, suggesting that mild…”
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