Search Results - "Knopman, David S"

Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019 by Knopman, David S., Jones, David T., Greicius, Michael D.

“…Aducanumab recently underwent two large phase III clinical trials that were stopped prematurely by the sponsor Biogen. One trial was trending positive while…”
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Mild Cognitive Impairment and Mild Dementia: A Clinical Perspective by Knopman, David S., MD, Petersen, Ronald C., PhD, MD

“…Abstract Mild cognitive impairment and mild dementia are common problems in the elderly. Primary care physicians are the first point of contact for most…”
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Classification and Epidemiology of MCI by Roberts, Rosebud, MS, MB ChB, Knopman, David S., MD

“…Mild cognitive impairment (MCI) is an intermediate stage in the trajectory from normal cognition to dementia. Despite controversies about the classification of…”
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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers by Jack, Clifford R, Prof Dr, Knopman, David S, Prof, Jagust, William J, Prof, Petersen, Ronald C, Prof, Weiner, Michael W, Prof, Aisen, Paul S, Prof, Shaw, Leslie M, Prof, Vemuri, Prashanthi, PhD, Wiste, Heather J, Weigand, Stephen D, Lesnick, Timothy G, Pankratz, Vernon S, PhD, Donohue, Michael C, PhD, Trojanowski, John Q, Prof

“…Summary In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease (AD). The model was received with interest because we…”
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Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition by Gottesman, Rebecca F, Schneider, Andrea L. C, Zhou, Yun, Coresh, Josef, Green, Edward, Gupta, Naresh, Knopman, David S, Mintz, Akiva, Rahmim, Arman, Sharrett, A. Richey, Wagenknecht, Lynne E, Wong, Dean F, Mosley, Thomas H

“…IMPORTANCE: Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid…”
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Cascading network failure across the Alzheimer's disease spectrum by Jones, David T, Knopman, David S, Gunter, Jeffrey L, Graff-Radford, Jonathan, Vemuri, Prashanthi, Boeve, Bradley F, Petersen, Ronald C, Weiner, Michael W, Jack, Jr, Clifford R

“…Complex biological systems are organized across various spatiotemporal scales with particular scientific disciplines dedicated to the study of each scale (e.g…”
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Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association by Iadecola, Costantino, Yaffe, Kristine, Biller, José, Bratzke, Lisa C, Faraci, Frank M, Gorelick, Philip B, Gulati, Martha, Kamel, Hooman, Knopman, David S, Launer, Lenore J, Saczynski, Jane S, Seshadri, Sudha, Zeki Al Hazzouri, Adina

“…BACKGROUND—Age-related dementia, most commonly caused by Alzheimer disease or cerebrovascular factors (vascular dementia), is a major public health threat…”
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Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort by Gottesman, Rebecca F, Albert, Marilyn S, Alonso, Alvaro, Coker, Laura H, Coresh, Josef, Davis, Sonia M, Deal, Jennifer A, McKhann, Guy M, Mosley, Thomas H, Sharrett, A Richey, Schneider, Andrea L C, Windham, B Gwen, Wruck, Lisa M, Knopman, David S

“…Vascular risk factors have been associated with cognitive decline. Midlife exposure to these factors may be most important in conferring late-life risk of…”
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TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A by Ma, X. Rosa, Prudencio, Mercedes, Koike, Yuka, Vatsavayai, Sarat C., Kim, Garam, Harbinski, Fred, Briner, Adam, Rodriguez, Caitlin M., Guo, Caiwei, Akiyama, Tetsuya, Schmidt, H. Broder, Cummings, Beryl B., Wyatt, David W., Kurylo, Katherine, Miller, Georgiana, Mekhoubad, Shila, Sallee, Nathan, Mekonnen, Gemechu, Ganser, Laura, Rubien, Jack D., Jansen-West, Karen, Cook, Casey N., Pickles, Sarah, Oskarsson, Björn, Graff-Radford, Neill R., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Shorter, James, Myong, Sua, Green, Eric M., Seeley, William W., Petrucelli, Leonard, Gitler, Aaron D.

“…A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of…”
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Defining imaging biomarker cut points for brain aging and Alzheimer's disease by Jack, Clifford R, Wiste, Heather J, Weigand, Stephen D, Therneau, Terry M, Lowe, Val J, Knopman, David S, Gunter, Jeffrey L, Senjem, Matthew L, Jones, David T, Kantarci, Kejal, Machulda, Mary M, Mielke, Michelle M, Roberts, Rosebud O, Vemuri, Prashanthi, Reyes, Denise A, Petersen, Ronald C

“…Abstract Introduction Our goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro-deoxyglucose (FDG) PET, and MRI…”
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Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia by Roberts, Rosebud O, Christianson, Teresa J H, Kremers, Walter K, Mielke, Michelle M, Machulda, Mary M, Vassilaki, Maria, Alhurani, Rabe E, Geda, Yonas E, Knopman, David S, Petersen, Ronald C

“…To increase the opportunity to delay or prevent mild cognitive impairment (MCI) or Alzheimer disease (AD) dementia, markers of early detection are essential…”
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Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study by Whitwell, Jennifer L, Dr, Dickson, Dennis W, Prof, Murray, Melissa E, PhD, Weigand, Stephen D, MS, Tosakulwong, Nirubol, BS, Senjem, Matthew L, MS, Knopman, David S, Prof, Boeve, Bradley F, Prof, Parisi, Joseph E, Prof, Petersen, Ronald C, Prof, Jack, Clifford R, Prof, Josephs, Keith A, Prof

“…Summary Background Three subtypes of Alzheimer's disease (AD) have been pathologically defined on the basis of the distribution of neurofibrillary tangles:…”
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Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set by Besser, Lilah, Kukull, Walter, Knopman, David S, Chui, Helena, Galasko, Douglas, Weintraub, Sandra, Jicha, Gregory, Carlsson, Cynthia, Burns, Jeffrey, Quinn, Joseph, Sweet, Robert A, Rascovsky, Katya, Teylan, Merilee, Beekly, Duane, Thomas, George, Bollenbeck, Mark, Monsell, Sarah, Mock, Charles, Zhou, Xiao Hua, Thomas, Nicole, Robichaud, Elizabeth, Dean, Margaret, Hubbard, Janene, Jacka, Mary, Schwabe-Fry, Kristen, Wu, Joylee, Phelps, Creighton, Morris, John C

“…INTRODUCTION:In 2015, the US Alzheimer’s Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version…”
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Non-stationarity in the "resting brain's" modular architecture by Jones, David T, Vemuri, Prashanthi, Murphy, Matthew C, Gunter, Jeffrey L, Senjem, Matthew L, Machulda, Mary M, Przybelski, Scott A, Gregg, Brian E, Kantarci, Kejal, Knopman, David S, Boeve, Bradley F, Petersen, Ronald C, Jack, Jr, Clifford R

“…Task-free functional magnetic resonance imaging (TF-fMRI) has great potential for advancing the understanding and treatment of neurologic illness. However, as…”
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Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS by DeJesus-Hernandez, Mariely, Mackenzie, Ian R., Boeve, Bradley F., Boxer, Adam L., Baker, Matt, Rutherford, Nicola J., Nicholson, Alexandra M., Finch, NiCole A., Flynn, Heather, Adamson, Jennifer, Kouri, Naomi, Wojtas, Aleksandra, Sengdy, Pheth, Hsiung, Ging-Yuek R., Karydas, Anna, Seeley, William W., Josephs, Keith A., Coppola, Giovanni, Geschwind, Daniel H., Wszolek, Zbigniew K., Feldman, Howard, Knopman, David S., Petersen, Ronald C., Miller, Bruce L., Dickson, Dennis W., Boylan, Kevin B., Graff-Radford, Neill R., Rademakers, Rosa

“…Several families have been reported with autosomal-dominant frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), genetically linked to…”
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Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study by Jack, Clifford R, Prof, Wiste, Heather J, BA, Weigand, Stephen D, MS, Therneau, Terry M, Prof, Knopman, David S, Prof, Lowe, Val, Prof, Vemuri, Prashanthi, PhD, Mielke, Michelle M, Prof, Roberts, Rosebud O, Prof, Machulda, Mary M, PhD, Senjem, Matthew L, MS, Gunter, Jeffrey L, PhD, Rocca, Walter A, Prof, Petersen, Ronald C, Prof

“…Summary Background A new classification for biomarkers in Alzheimer's disease and cognitive ageing research is based on grouping the markers into three…”
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade by Jack, Clifford R, MD, Knopman, David S, MD, Jagust, William J, MD, Shaw, Leslie M, PhD, Aisen, Paul S, MD, Weiner, Michael W, MD, Petersen, Ronald C, MD, Trojanowski, John Q, PhD

“…Summary Currently available evidence strongly supports the position that the initiating event in Alzheimer's disease (AD) is related to abnormal processing of…”
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Age, vascular health, and Alzheimer disease biomarkers in an elderly sample by Vemuri, Prashanthi, Lesnick, Timothy G., Przybelski, Scott A., Knopman, David S., Lowe, Val J., Graff‐Radford, Jonathan, Roberts, Rosebud O., Mielke, Michelle M., Machulda, Mary M., Petersen, Ronald C., Jack, Clifford R.

“…Objective To investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample. Methods We…”
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Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging by Pittock, Rioghna R, Aakre, Jeremiah A, Castillo, Anna M, Ramanan, Vijay K, Kremers, Walter K, Jack, Jr, Clifford R, Vemuri, Prashanthi, Lowe, Val J, Knopman, David S, Petersen, Ronald C, Graff-Radford, Jonathan, Vassilaki, Maria

“…Treatment options for Alzheimer disease (AD) are limited and have focused mainly on symptomatic therapy and improving quality of life. Recently, lecanemab, an…”
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An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease by Jack Jr, Clifford R., Knopman, David S., Weigand, Stephen D., Wiste, Heather J., Vemuri, Prashanthi, Lowe, Val, Kantarci, Kejal, Gunter, Jeffrey L., Senjem, Matthew L., Ivnik, Robert J., Roberts, Rosebud O., Rocca, Walter A., Boeve, Bradley F., Petersen, Ronald C.

“…Objective: A workgroup commissioned by the Alzheimer's Association (AA) and the National Institute on Aging (NIA) recently published research criteria for…”
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