Search Results - "Knopf, Julia D"

RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling by Knopf, Julia D., Steigleder, Susanne S., Korn, Friederike, Kühnle, Nathalie, Badenes, Marina, Tauber, Marina, Theobald, Sebastian J., Rybniker, Jan, Adrain, Colin, Lemberg, Marius K.

“…The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily recognizes bacterial lipopolysaccharide cell wall constituents to…”
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Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation by Knopf, Julia D, Landscheidt, Nina, Pegg, Cassandra L, Schulz, Benjamin L, Kühnle, Nathalie, Chao, Chao-Wei, Huck, Simon, Lemberg, Marius K

“…The endoplasmic reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated…”
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Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations by Tholen, Stefan, Wolf, Cristina, Mayer, Bettina, Knopf, Julia D, Löffek, Stefanie, Qian, Yawen, Kizhakkedathu, Jayachandran N, Biniossek, Martin L, Franzke, Claus-Werner, Schilling, Oliver

“…Keratinocyte-specific deletion of ADAM17 in mice impairs terminal differentiation of keratinocytes leading to severe epidermal barrier defects. Mice deficient…”
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E3 ubiquitin ligases SMURF1 and HECW1 regulate hepcidin-induced degradation of ferroportin in HeLa cells by Link, Camille J., Marques, Oriana, Knopf, Julia D., Lemberg, Marius K., Muckenthaler, Martina U.

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Derlins with scissors: primordial ERAD in bacteria by Knopf, Julia D, Lemberg, Marius K

“…Rhomboid intramembrane serine proteases are present in all kingdoms of life, but as we do not know their substrates in many species, it remains puzzling why…”
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CRISPR-Cas12a-assisted PCR tagging of mammalian genes by Fueller, Julia, Herbst, Konrad, Meurer, Matthias, Gubicza, Krisztina, Kurtulmus, Bahtiyar, Knopf, Julia D, Kirrmaier, Daniel, Buchmuller, Benjamin C, Pereira, Gislene, Lemberg, Marius K, Knop, Michael

“…Here we describe a time-efficient strategy for endogenous C-terminal gene tagging in mammalian tissue culture cells. An online platform is used to design two…”
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Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation by Bock, Josephine, Kühnle, Nathalie, Knopf, Julia D., Landscheidt, Nina, Lee, Jin-Gu, Ye, Yihong, Lemberg, Marius K.

“…Protein degradation is fundamentally important to ensure cell homeostasis. In the endoplasmic reticulum (ER), the ER-associated degradation (ERAD) pathway…”
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The role of cellular iron deficiency in controlling iron export by Link, Camille, Knopf, Julia D., Marques, Oriana, Lemberg, Marius K., Muckenthaler, Martina U.

“…Iron export via the transport protein ferroportin (Fpn) plays a critical role in the regulation of dietary iron absorption and iron recycling in macrophages…”
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Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα by Wunderle, Lina, Knopf, Julia D., Kühnle, Nathalie, Morlé, Aymeric, Hehn, Beate, Adrain, Colin, Strisovsky, Kvido, Freeman, Matthew, Lemberg, Marius K.

“…Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans , but little…”
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The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia by Knopf, Julia D., Tholen, Stefan, Koczorowska, Maria M., De Wever, Olivier, Biniossek, Martin L., Schilling, Oliver

“…Fibroblast activation protein alpha (FAPα) is a cell surface protease expressed by cancer-associated fibroblasts in the microenvironment of most solid tumors…”
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Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation by Knopf, Julia D, Landscheidt, Nina, Pegg, Cassandra L, Schulz, Benjamin L, Kühnle, Nathalie, Chao, Chao-Wei, Huck, Simon, Lemberg, Marius K

“…The Endoplasmic Reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated…”
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Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGF[alpha] by Wunderle, Lina, Knopf, Julia D, Kühnle, Nathalie, Morlé, Aymeric, Hehn, Beate, Adrain, Colin, Strisovsky, Kvido, Freeman, Matthew, Lemberg, Marius K

“…Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little…”
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