Search Results - "Knop, David"

Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression by Mueller, Christian, Chulay, Jeffrey D, Trapnell, Bruce C, Humphries, Margaret, Carey, Brenna, Sandhaus, Robert A, McElvaney, Noel G, Messina, Louis, Tang, Qiushi, Rouhani, Farshid N, Campbell-Thompson, Martha, Fu, Ann Dongtao, Yachnis, Anthony, Knop, David R, Ye, Guo-Jie, Brantly, Mark, Calcedo, Roberto, Somanathan, Suryanarayan, Richman, Lee P, Vonderheide, Robert H, Hulme, Maigan A, Brusko, Todd M, Wilson, James M, Flotte, Terence R

“…Recombinant adeno-associated virus (rAAV) vectors have shown promise for the treatment of several diseases; however, immune-mediated elimination of transduced…”
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Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies by Clément, Nathalie, Knop, David R, Byrne, Barry J

“…The ability of recombinant adeno-associated viral (rAAV) vectors to exhibit minimal immunogenicity and little to no toxicity or inflammation while eliciting…”
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Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method by Chulay, Jeffrey D, Ye, Guo-Jie, Thomas, Darby L, Knop, David R, Benson, Janet M, Hutt, Julie A, Wang, Gensheng, Humphries, Margaret, Flotte, Terence R

“…Recombinant adeno-associated virus (rAAV) vectors offer promise for gene therapy of alpha-1 antitrypsin (AAT) deficiency. A toxicology study in mice evaluated…”
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Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells by Thomas, Darby L, Wang, Lijun, Niamke, Justine, Liu, Jilin, Kang, Wen, Scotti, Marina M, Ye, Guo-jie, Veres, Gabor, Knop, David R

“…Recombinant adeno-associated virus (rAAV) production systems capable of meeting clinical or anticipated commercial-scale manufacturing needs have received…”
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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin by Ye, Guo-Jie, Budzynski, Ewa, Sonnentag, Peter, Miller, Paul E, Sharma, Alok K, Ver Hoeve, James N, Howard, Kellie, Knop, David R, Neuringer, Martha, McGill, Trevor, Stoddard, Jonathan, Chulay, Jeffrey D

“…Applied Genetic Technologies Corporation is developing rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus (rAAV) vector for treatment of X-linked…”
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Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia Sheep by Gootwine, Elisha, Ofri, Ron, Banin, Eyal, Obolensky, Alexey, Averbukh, Edward, Ezra-Elia, Raaya, Ross, Maya, Honig, Hen, Rosov, Alexander, Yamin, Esther, Ye, Guo-Jie, Knop, David R, Robinson, Paulette M, Chulay, Jeffrey D, Shearman, Mark S

“…Applied Genetic Technologies Corporation (AGTC) is developing a recombinant adeno-associated virus (rAAV) vector expressing the human CNGA3 gene designated…”
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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia by Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T Michael, Miller, Paul E, Sharma, Alok K, Ver Hoeve, James N, Smith, Leia M, Arndt, Tara, Calcedo, Roberto, Gaskin, Chantelle, Robinson, Paulette M, Knop, David R, Hauswirth, William W, Chulay, Jeffrey D

“…Applied Genetic Technologies Corporation (AGTC) is developing rAAV2tYF-PR1.7-hCNGB3, a recombinant adeno-associated viral (rAAV) vector expressing the human…”
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Safety and Biodistribution Evaluation in CNGB3-Deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia by Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T Michael, Miller, Paul E, McPherson, Leslie, Ver Hoeve, James N, Smith, Leia M, Arndt, Tara, Mandapati, Savitri, Robinson, Paulette M, Calcedo, Roberto, Knop, David R, Hauswirth, William W, Chulay, Jeffrey D

“…Applied Genetic Technologies Corporation (AGTC) is developing rAAV2tYF-PR1.7-hCNGB3, a recombinant adeno-associated virus (rAAV) vector expressing the human…”
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Safety and Biodistribution Evaluation of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin, in RS1-Deficient Mice by Ye, Guo-Jie, Conlon, Thomas, Erger, Kirsten, Sonnentag, Peter, Sharma, Alok K, Howard, Kellie, Knop, David R, Chulay, Jeffrey D

“…Applied Genetic Technologies Corporation is developing a recombinant adeno-associated virus (rAAV) vector for treatment of X-linked retinoschisis (XLRS), an…”
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Bioreactor Production of Recombinant Herpes Simplex Virus Vectors by Knop, David R., Harrell, Heather

“…Serotypical application of herpes simplex virus (HSV) vectors to gene therapy (type 1) and prophylactic vaccines (types 1 and 2) has garnered substantial…”
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Herpes simplex virus clearance during purification of a recombinant adeno-associated virus serotype 1 vector by Ye, Guo-jie, Scotti, Marina M, Thomas, Darby L, Wang, Lijun, Knop, David R, Chulay, Jeffrey D

“…Gene delivery vectors based on adeno-associated virus (AAV) have potential utility for treatment of many genetic disorders. Current AAV vector manufacturing…”
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Hydroaromatic Equilibration During Biosynthesis of Shikimic Acid by Knop, David R, Draths, K. M, Chandran, Sunil S, Barker, Jessica L, von Daeniken, Ralph, Weber, Wolfgang, Frost, J. W

“…The expense and limited availability of shikimic acid isolated from plants has impeded utilization of this hydroaromatic as a synthetic starting material…”
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Shikimic Acid and Quinic Acid:  Replacing Isolation from Plant Sources with Recombinant Microbial Biocatalysis by Draths, K. M, Knop, David R, Frost, J. W

“…Shikimic acid and quinic acid, hydroaromatics metabolically linked by the common pathway of aromatic amino acid biosynthesis (Scheme 1), have emerged as…”
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Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results by Flotte, Terence R, Trapnell, Bruce C, Humphries, Margaret, Carey, Brenna, Calcedo, Roberto, Rouhani, Farshid, Campbell-Thompson, Martha, Yachnis, Anthony T, Sandhaus, Robert A, McElvaney, Noel G, Mueller, Christian, Messina, Louis M, Wilson, James M, Brantly, Mark, Knop, David R, Ye, Guo-jie, Chulay, Jeffrey D

“…Recombinant adeno-associated virus (rAAV) vectors offer promise for the gene therapy of α(1)-antitrypsin (AAT) deficiency. In our prior trial, an rAAV vector…”
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Benzene-Free Synthesis of Hydroquinone by Ran, Ningqing, Knop, David R, Draths, K. M, Frost, J. W

“…All current routes for the synthesis of hydroquinone utilize benzene as the starting material. An alternate route to hydroquinone has now been elaborated from…”
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510. Detection and Quantification of rcAAV in rAAV Stocks by Real-Time qPCR by Mayfield, Traci L., Korytov, Irina, Francis, Joyce D., Knop, David R., Snyder, Richard O.

“…The packaging of recombinant DNA into adeno-associated viral vectors for gene therapy protocols may incur contamination by wild-type adeno-associated virus…”
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470. Efficient Clearance of Herpes Simplex Virus Using a GMP-Compliant Method for Production of Recombinant Adeno-Associated Virus Vectors by Ye, Guo-jie, Gaskin, Chantelle, Butts, Charlotte, Threadgill, Royce, Knop, David R., Chulay, Jeffrey D.

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663. Safety and Biodistribution Study of rAAV2tYF-CB-hRS1 in Nonhuman Primates by Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Miller, Paul, Sharma, Alok K., Hoeve, James, Latimer, Kenneth S., Howard, Kellie, Knop, David R., Chulay, Jeffrey D.

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463. Safety and Biodistribution Study of rAAV2tYF-CB-hRS1 in RS1-deficient Mice by Ye, Guo-jie, Conlon, Thomas, Erger, Kirsten, Sonnentag, Peter, Sharma, Alok K., Tripathi Tripathi, Niraj, Howard, Kellie, Knop, David R., Chulay, Jeffrey D.

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299. Safety and Biodistribution Study of rAAV2tYF-PR1.7-hCNGB3 in CNGB3-Deficient Mice by Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T. Michael, Miller, Paul E., McPherson, Leslie, Hoeve, James N. Ver, Smith, Leia M., Arndt, Tara Arndt, Mandapati, Savitri, Robinson, Paulette M., Calcedo, Roberto, Knop, David R., Hauswirth, William W., Chulay, Jeffrey D.

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