Search Results - "Knoll, Patrick"

Thiolated Hydroxypropyl-β-cyclodextrin: A Potential Multifunctional Excipient for Ocular Drug Delivery by Grassiri, Brunella, Knoll, Patrick, Fabiano, Angela, Piras, Anna Maria, Zambito, Ylenia, Bernkop-Schnürch, Andreas

“…The goal of this study was the design and evaluation of a thiolated cyclodextrin providing high drug solubilizing and mucoadhesive properties for ocular drug…”
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Nanostructured Lipid Carriers (NLCs) for Oral Peptide Drug Delivery: About the Impact of Surface Decoration by Shahzadi, Iram, Fürst, Andrea, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…This study was aimed to evaluate the impact of surfactants used for nanostructured lipid carriers (NLCs) to provide enzymatic protection for incorporated…”
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Chitosan – Polyphosphate nanoparticles for a targeted drug release at the absorption membrane by Saleh, Ahmad, Akkuş-Dağdeviren, Zeynep Burcu, Friedl, Julian David, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…The aim of this study was to develop nanoparticles (NPs) providing a targeted drug release directly on the epithelium of the intestinal mucosa. NPs were…”
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Emerging technologies to increase gastrointestinal transit times of drug delivery systems by Kali, Gergely, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…Apart from already established technologies to increase gastrointestinal transit times, including devices rapidly increasing in size once they have reached the…”
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Thiolated cyclodextrins: Mucoadhesive and permeation enhancing excipients for ocular drug delivery by Asim, Mulazim Hussain, Ijaz, Muhammad, Mahmood, Arshad, Knoll, Patrick, Jalil, Aamir, Arshad, Shumaila, Bernkop-Schnürch, Andreas

“…[Display omitted] •Thiolated β-CD was synthesized by replacing primary –OH groups with thiol groups.•Thiolated β-CD showed no inflammation on ocular mucosa…”
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Three generations of thiolated cyclodextrins: A direct comparison of their mucus permeating and mucoadhesive properties by Haddadzadegan, Soheil, Knoll, Patrick, Wibel, Richard, Kali, Gergely, Bernkop-Schnürch, Andreas

“…This study aims to compare the mucus permeating and mucoadhesive properties of three generations of thiolated cyclodextrins (CDs). Free thiol groups of…”
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Design of nanostructured lipid carriers and solid lipid nanoparticles for enhanced cellular uptake by Veider, Florina, Akkuş-Dağdeviren, Zeynep Burcu, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…[Display omitted] In this study PEG-free and zeta potential changing lipid-based nanocarriers providing enhanced cellular uptake were developed. Nanostructured…”
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Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin by Zöller, Katrin, To, Dennis, Knoll, Patrick, Bernkop-Schnürch, Andreas

“…[Display omitted] The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various…”
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Corrigendum to “Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense” [J. Colloid Interface Sci. 630(Part B) (2023) 164–178] by To, Dennis, Kakar, Anant, Kali, Gergely, Wibel, Richard, Knoll, Patrick, Marx, Florentine, Bernkop-Schnürch, Andreas

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PEG vs. zwitterions: How these surface decorations determine cellular uptake of lipid-based nanocarriers by Stengel, Daniel, Demirel, Betül Hilal, Knoll, Patrick, Truszkowska, Martyna, Laffleur, Flavia, Bernkop-Schnürch, Andreas

“…[Display omitted] To evaluate the impact of polyethylene glycol (PEG) and zwitterionic surface decoration of lipid-based nanocarriers (NC) on cellular uptake…”
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Oral drug delivery: Influence of mucus on cellular interactions and uptake of lipid-based nanocarriers in Caco-2 cells by Veider, Florina, Knoll, Patrick, Jörgensen, Arne Matteo, Stengel, Daniel, Bernkop-Schnürch, Andreas

“…This study aimed to investigate the impact of the mucus gel barrier on intestinal mucosal uptake of lipid-based nanocarriers (NCs). Zwitterionic- (ZW),…”
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Synthesis and evaluation of sulfosuccinate-based surfactants as counterions for hydrophobic ion pairing by Wibel, Richard, Knoll, Patrick, Le-Vinh, Bao, Kali, Gergely, Bernkop-Schnürch, Andreas

“…Hydrophobic ion pairing is a promising strategy to raise the lipophilic character of therapeutic peptides and proteins. In past studies, docusate, an…”
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Lipid-based nanoparticles: Enhanced cellular uptake via surface thiolation by Knoll, Patrick, Francesco Racaniello, Giuseppe, Laquintana, Valentino, Veider, Florina, Saleh, Ahmad, Seybold, Anna, Denora, Nunzio, Bernkop-Schnürch, Andreas

“…[Display omitted] The aim of this study was to evaluate the uptake mechanism of thiolated nanostructured lipid carriers (NLCs). NLCs were decorated with a…”
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Iminated aminoglycosides in self-emulsifying drug delivery systems: Dual approach to break down the microbial defense by To, Dennis, Kakar, Anant, Kali, Gergely, Wibel, Richard, Knoll, Patrick, Marx, Florentine, Bernkop-Schnürch, Andreas

“…[Display omitted] Aminoglycosides are well known, cationic antimicrobial drugs. However, biofilm-based antibiotic resistance significantly limits their…”
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Thiolated pectins: In vitro and ex vivo evaluation of three generations of thiomers by Knoll, Patrick, Le, Nguyet-Minh Nguyen, Wibel, Richard, Baus, Randi Angela, Kali, Gergely, Asim, Mulazim Hussain, Bernkop-Schnürch, Andreas

“…In recent decades, three generations of thiomers have been developed with the main purpose of obtaining enhanced interactions with mucosal tissues. Therefore,…”
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In Vitro Investigation of Thiolated Chitosan Derivatives as Mucoadhesive Coating Materials for Solid Lipid Nanoparticles by Wibel, Richard, Braun, Doris E, Hämmerle, Laurenz, Jörgensen, Arne M, Knoll, Patrick, Salvenmoser, Willi, Steinbring, Christian, Bernkop-Schnürch, Andreas

“…In the present study, chitosan (CS) was thiolated by introducing l-cysteine via amide bond formation. Free thiol groups were protected with highly reactive…”
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Thiolated α-cyclodextrin: The likely smallest drug carrier providing enhanced cellular uptake and endosomal escape by Kaplan, Özlem, Truszkowska, Martyna, Kali, Gergely, Knoll, Patrick, Blanco Massani, Mariana, Braun, Doris Elfriede, Bernkop-Schnürch, Andreas

“…This study aimed to evaluate the effect of thiolated α-cyclodextrin (α-CD-SH) on the cellular uptake of its payload. For this purpose, α-CD was thiolated using…”
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Biodegradable arginine based steroid-surfactants: Cationic green agents for hydrophobic ion-pairing by Matteo Jörgensen, Arne, Knoll, Patrick, Haddadzadegan, Soheil, Fabian, Hannah, Hupfauf, Andrea, Gust, Ronald, Georg Jörgensen, Rainer, Bernkop-Schnürch, Andreas

“…[Display omitted] The aim of this study was to evaluate the safety and efficacy for hydrophobic ion-pairing of surfactants based on arginine (Arg). The…”
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Thiolation of non-ionic surfactants for the development of lipid-based mucoadhesive drug delivery systems by Racaniello, Giuseppe Francesco, Knoll, Patrick, Jörgensen, Arne Matteo, Arduino, Ilaria, Laquintana, Valentino, Lopedota, Angela Assunta, Bernkop-Schnürch, Andreas, Denora, Nunzio

“…[Display omitted] The aim of this study was to develop thiolated self-emulsifying drug delivery systems (SEDDS) and nanostructured lipid carriers (NLCs) with…”
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Charge converting nanostructured lipid carriers containing a cell-penetrating peptide for enhanced cellular uptake by Knoll, Patrick, Hörmann, Nikolas, Nguyen Le, Nguyet-Minh, Wibel, Richard, Gust, Ronald, Bernkop-Schnürch, Andreas

“…[Display omitted] The aim of this study was the development of nanostructured lipid carriers (NLCs) decorated with a polycationic cell-penetrating peptide…”
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