Search Results - "Knoll, Mareike"

P1206: A SINGLE‐CELL MULTI‐OMIC AND SPATIAL ATLAS OF NODAL B CELL NON‐HODGKIN LYMPHOMAS REVEALS PLASTICITY IN B CELL MATURATION AS A DRIVER OF INTRATUMOR HETEROGENEITY by Fitzgerald, Donnacha, Kibler, Artur, Baertsch, Marc‐A., Roider, Tobias, Vohringer, Harald, Horlova, Anastasiia, Mathioudaki, Anna, Budeus, Bettina, Knoll, Mareike, Chung, Erin, Mammen, Johannes, Caille, Leandra, Passerini, Verena, Czernilofsky, Felix, LI, Linsha, Weigert, Oliver, Zaugg, Judith B., Nolan, Gary P., Seifert, Marc, Huber, Wolfgang, Dietrich, Sacha

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Phagocytosis by stroma confounds coculture studies by Herbst, Sophie A., Stolarczyk, Marta, Becirovic, Tina, Czernilofsky, Felix, Liu, Yi, Kolb, Carolin, Knoll, Mareike, Herling, Marco, Müller-Tidow, Carsten, Dietrich, Sascha

“…Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. Bone marrow stromal cell…”
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Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1 by Janssen, Maike, Schmidt, Christina, Bruch, Peter-Martin, Blank, Maximilian F., Rohde, Christian, Waclawiczek, Alexander, Heid, Daniel, Renders, Simon, Göllner, Stefanie, Vierbaum, Lisa, Besenbeck, Birgit, Herbst, Sophie A., Knoll, Mareike, Kolb, Carolin, Przybylla, Adriana, Weidenauer, Katharina, Ludwig, Anne Kathrin, Fabre, Margarete, Gu, Muxin, Schlenk, Richard F., Stölzel, Friedrich, Bornhäuser, Martin, Röllig, Christoph, Platzbecker, Uwe, Baldus, Claudia, Serve, Hubert, Sauer, Tim, Raffel, Simon, Pabst, Caroline, Vassiliou, George, Vick, Binje, Jeremias, Irmela, Trumpp, Andreas, Krijgsveld, Jeroen, Müller-Tidow, Carsten, Dietrich, Sascha

“…•High-throughput drug screening identified gilteritinib and venetoclax as a highly synergistic drug combination in FLT3 wild-type AML.•Gilteritinib-venetoclax…”
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Single-Cell Multi-Omic and Spatial Analysis of Nodal B Cell Non-Hodgkin Lymphomas Reveals Plasticity in B Cell Maturation As a Driver of Intratumor Heterogeneity by Fitzgerald, Donnacha, Roider, Tobias, Baertsch, Marc-A., Vöhringer, Harald, Knoll, Mareike, Budeus, Bettina, Kibler, Artur, Mathioudaki, Anna, Caillé, Léandra, Li, Linsha, Mammen, Johannes, Seifert, Marc, Huber, Wolfgang, Dietrich, Sascha

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Proteogenomics refines the molecular classification of chronic lymphocytic leukemia by Herbst, Sophie A., Vesterlund, Mattias, Helmboldt, Alexander J., Jafari, Rozbeh, Siavelis, Ioannis, Stahl, Matthias, Schitter, Eva C., Liebers, Nora, Brinkmann, Berit J., Czernilofsky, Felix, Roider, Tobias, Bruch, Peter-Martin, Iskar, Murat, Kittai, Adam, Huang, Ying, Lu, Junyan, Richter, Sarah, Mermelekas, Georgios, Umer, Husen Muhammad, Knoll, Mareike, Kolb, Carolin, Lenze, Angela, Cao, Xiaofang, Österholm, Cecilia, Wahnschaffe, Linus, Herling, Carmen, Scheinost, Sebastian, Ganzinger, Matthias, Mansouri, Larry, Kriegsmann, Katharina, Kriegsmann, Mark, Anders, Simon, Zapatka, Marc, Del Poeta, Giovanni, Zucchetto, Antonella, Bomben, Riccardo, Gattei, Valter, Dreger, Peter, Woyach, Jennifer, Herling, Marco, Müller-Tidow, Carsten, Rosenquist, Richard, Stilgenbauer, Stephan, Zenz, Thorsten, Huber, Wolfgang, Tausch, Eugen, Lehtiö, Janne, Dietrich, Sascha

“…Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and…”
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Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities by Roider, Tobias, Baertsch, Marc A., Fitzgerald, Donnacha, Vöhringer, Harald, Brinkmann, Berit J., Czernilofsky, Felix, Knoll, Mareike, Llaó-Cid, Laura, Mathioudaki, Anna, Faßbender, Bianca, Herbon, Maxime, Lautwein, Tobias, Bruch, Peter-Martin, Liebers, Nora, Schürch, Christian M., Passerini, Verena, Seifert, Marc, Brobeil, Alexander, Mechtersheimer, Gunhild, Müller-Tidow, Carsten, Weigert, Oliver, Seiffert, Martina, Nolan, Garry P., Huber, Wolfgang, Dietrich, Sascha

“…The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of…”
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Ex-Vivo Drug Response Profiling for Tailoring Treatment in Hematologic Malignancies: The Prospective Non-Interventional SMART-Trial by Liebers, Nora, Bruch, Peter-Martin, Gambietz, Agnes, Giles, Holly, Lu, Junyan, Knoll, Mareike, Kolb, Carolin, Dreger, Peter, Mueller-Tidow, Carsten, Huber, Wolfgang, Benner, Axel, Zenz, Thorsten, Dietrich, Sascha

“…Introduction Ex-vivo drug response profiling (DRP) represents a promising strategy to better understand the tumor's pathway dependencies, genotype-phenotype…”
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Systematic Investigation of Microenvironmental Drug Resistance Mechanisms in Chronic Lymphocytic Leukemia by Bruch, Peter-Martin, Giles, Holly, Kolb, Carolin, Rabe, Sophie, Roider, Tobias, Knoll, Mareike, Kriegsmann, Mark, Kriegsmann, Katharina, Zgorzelski, Christiane, Scheinost, Sebastian, Wagner, Lena, Müller-Tidow, Carsten, Zenz, Thorsten, Huber, Wolfgang, Dietrich, Sascha

“…Introduction and Methods To investigate the mechanisms by which microenvironmental signals induce treatment resistance in chronic lymphocytic leukemia (CLL) we…”
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Proteogenomic Subtyping of Chronic Lymphocytic Leukemia Identifies a Novel Poor Outcome Subgroup with a Distinct Drug Response Profile by Herbst, Sophie A., Vesterlund, Mattias, Jafari, Rozbeh, Siavelis, Ioannis, Stahl, Matthias, Schitter, Eva, Helmboldt, Alexander J., Iskar, Murat, Liebers, Nora, Czernilofsky, Felix, Roider, Tobias, Bruch, Peter-Martin, Lu, Junyan, Richter, Sarah, Mermelekas, Georgios, Umer, Husen Muhammad, Knoll, Mareike, Kolb, Carolin, Lenze, Angela, Cao, Xiaofang, Österholm-Corbascio, Cecilia, Scheinost, Sebastian, Ganzinger, Matthias, Mansouri, Larry, Kriegsmann, Katharina, Kriegsmann, Mark, Mueller-Tidow, Carsten, Dreger, Peter, Anders, Simon, Zapatka, Marc, Herling, Marco, Rosenquist, Richard, Stilgenbauer, Stephan, Zenz, Thorsten, Huber, Wolfgang, Tausch, Eugen, Lehtiö, Janne, Dietrich, Sascha

“…▪ Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world and shows a very heterogeneous clinical course. While…”
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Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial by Liebers, Nora, Bruch, Peter-Martin, Terzer, Tobias, Hernandez-Hernandez, Miguel, Paramasivam, Nagarajan, Fitzgerald, Donnacha, Altmann, Heidi, Roider, Tobias, Kolb, Carolin, Knoll, Mareike, Lenze, Angela, Platzbecker, Uwe, Röllig, Christoph, Baldus, Claudia, Serve, Hubert, Bornhäuser, Martin, Hübschmann, Daniel, Müller-Tidow, Carsten, Stölzel, Friedrich, Huber, Wolfgang, Benner, Axel, Zenz, Thorsten, Lu, Junyan, Dietrich, Sascha

“…Ex vivo drug response profiling is a powerful tool to study genotype-drug response associations and is being explored as a tool set for precision medicine in…”
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An autologous culture model of nodal B-cell lymphoma identifies ex vivo determinants of response to bispecific antibodies by Roider, Tobias, Brinkmann, Berit J., Kim, Vladislav, Knoll, Mareike, Kolb, Carolin, Roessner, Philipp M., Bordas, Marie, Dreger, Peter, Müller-Tidow, Carsten, Huber, Wolfgang, Seiffert, Martina, Dietrich, Sascha

“…Bispecific antibodies (BsAbs) can induce long-term responses in patients with refractory and relapsed B-cell lymphoma. Nevertheless, response rates across…”
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Comparing the value of mono- vs coculture for high-throughput compound screening in hematological malignancies by Herbst, Sophie A., Kim, Vladislav, Roider, Tobias, Schitter, Eva C., Bruch, Peter-Martin, Liebers, Nora, Kolb, Carolin, Knoll, Mareike, Lu, Junyan, Dreger, Peter, Müller-Tidow, Carsten, Zenz, Thorsten, Huber, Wolfgang, Dietrich, Sascha

“…•Stromal coculture mediates resistance to various drug classes, including chemotherapeutics, B-cell receptor, proteasome, and BET inhibitors.•Detected…”
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Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies by Herbst, Sophie A, Kim, Vladislav, Roider, Tobias, Schitter, Eva C, Bruch, Peter-Martin, Liebers, Nora, Kolb, Carolin, Knoll, Mareike, Lu, Junyan, Dreger, Peter, Müller-Tidow, Carsten, Zenz, Thorsten, Huber, Wolfgang, Dietrich, Sascha

“…Large-scale compound screens are a powerful model system for understanding variability of treatment response and for discovering druggable tumor…”
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