Search Results - "Knobler, RL"

Interferon beta-1b in the treatment of multiple sclerosis : final outcome of the randomized controlled trial

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Inverse ocular bobbing by Knobler, R L, Somasundaram, M, Schutta, H S

“…A new form of abnormal spontaneous eye movement termed inverse ocular bobbing is described. It consists of a slow downward eye movement followed by delayed…”
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Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters by Tartaglino, L M, Friedman, D P, Flanders, A E, Lublin, F D, Knobler, R L, Liem, M

“…To determine the characteristic magnetic resonance (MR) imaging features of multiple sclerosis (MS) that affect the spinal cord. Sixty-eight patients underwent…”
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A multicenter, randomized, double-blind, placebo-controlled trial of influenza immunization in multiple sclerosis by Miller, A E, Morgante, L A, Buchwald, L Y, Nutile, S M, Coyle, P K, Krupp, L B, Doscher, C A, Lublin, F D, Knobler, R L, Trantas, F, Kelley, L, Smith, C R, La Rocca, N, Lopez, S

“…We determined the effect of influenza vaccine in patients with relapsing/remitting MS. Considerable controversy surrounds the question of whether to administer…”
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Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS by Rice, G P, Ebers, G C, Lublin, F D, Knobler, R L

“…Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose…”
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Cutaneous ulcerations and pustular psoriasis flare caused by recombinant interferon beta injections in patients with multiple sclerosis by Webster, G.F., Knobler, R.L., Lublin, F.D., Kramer, E.M., Hochman, L.R.

“…Seven patients with multiple sclerosis who were receiving subcutaneous injections of recombinant interferon beta had pain followed by ulceration at the…”
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Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material by Schweitzer, M E, Mandel, S, Schwartzman, R J, Knobler, R L, Tahmoush, A J

“…To determine the appearance of reflex sympathetic dystrophy (RSD) at magnetic resonance (MR) imaging. Fifty-one patients with suspected RSD were prospectively…”
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Improved intracranial lesion characterization by tissue segmentation based on a 3D feature map by Vinitski, S, Gonzalez, C, Mohamed, F, Iwanaga, T, Knobler, R L, Khalili, K, Mack, J

“…Our aim was to develop an accurate multispectral tissue segmentation method based on 3D feature maps. We utilized proton density (PD), T2-weighted fast…”
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Modulation of T cell-endothelial adhesion by astrocyte conditioned medium by Joseph, Jeymohan, Lublin, Fred D., Knobler, Robert L.

“…Astrocytes and derived factors maintain the morphologic, phenotypic, and physiological properties of the blood‐brain barrier. Astroglial cells may also…”
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Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis by Lublin, F D, Knobler, R L, Kalman, B, Goldhaber, M, Marini, J, Perrault, M, D'Imperio, C, Joseph, J, Alkan, S S, Korngold, R

“…Interferon-gamma (IFN-gamma) is a cytokine with multiple activities on a variety of cells. Under various circumstances, IFN-gamma can exhibit either…”
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A neurologic rating scale (NRS) for use in multiple sclerosis by SIPE, J. C, KNOBLER, R. L, BRAHENY, S. L, RICE, G. P. A, PANITCH, H. S, OLDSTONE, M. B. A

“…A neurologic rating scale (NRS) has been developed for clinical assessment of MS patients. The scale has been tested on 250 MS patients. Assignment of the NRS…”
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Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell--cell fusion by Collins, A R, Knobler, R L, Powell, H, Buchmeier, M J

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Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromosome 6 by Melvold, RW, Jokinen, DM, Knobler, RL, Lipton, HL

“…In some susceptible mouse strains, intracerebral (IC) inoculation of Theiler's murine encephalomyelitis virus (TMEV) results in a persistent infection leading…”
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The sensitivity of the Mini-Mental State Exam in the white matter dementia of multiple sclerosis by Swirsky-Sacchetti, T, Field, H L, Mitchell, D R, Seward, J, Lublin, F D, Knobler, R L, Gonzalez, C F

“…Fifty-six patients diagnosed with definite multiple sclerosis (MS) according to Poser criteria were administered the Mini-Mental State Examination (MMSE) and a…”
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Encephalitogenic T cell clones specific for myelin basic protein: an unusual bias in antigen recognition by ZAMVIL, S. S, NELSON, P. A, MITCHELL, D. J, KNOBLER, R. L, FRITZ, R. B, STEINMAN, L

“…Class II-restricted T cell clones specific for myelin basic protein (MBP) have been generated from PL/J and (PL/J X SJL/J)F1 [((PLSJ)F1] mice following…”
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Junctional region of the myelin basic protein-specific T cell receptor β chain in mice by Kalman, Bernadette, Alder, Hansjuerg, Knobler, Robert L.

“…Evidence for the existence of both conserved and diverse amino acid sequences in the Junctional regions of the myelin basic protein (MBP)-specific T cell…”
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Effects of staphylococcal enterotoxin B on T cell receptor V beta utilization and clinical manifestations of experimental allergic encephalomyelitis by Kalman, B, Lublin, F D, Lattime, E, Joseph, J, Knobler, R L

“…Staphylococcal enterotoxin B (SEB) is a superantigen (SA) that up-regulates and then subsequently down-regulates and deletes T cells expressing V beta 8 T cell…”
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Expression of the myelin basic protein gene in transgenic mice expressing human neurotropic virus, JCV, early protein by Haas, S, Haque, N S, Beggs, A H, Khalili, K, Knobler, R L, Small, J

“…Transgenic mice containing the early region of the JC virus encoding T-antigen developed neurological disease resulting from dysmyelination in the central…”
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Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia by Shy, M E, Evans, V A, Lublin, F D, Knobler, R L, Heiman-Patterson, T, Tahmoush, A J, Parry, G, Schick, P, DeRyk, T G

“…Fifty-nine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at…”
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Regulation of myelin basic protein gene transcription: identification of a distal cis-acting regulatory element by Haque, N S, Haas, S, Knobler, R L, Khalili, K

“…The myelin basic protein (MBP) gene contains sequences located upstream of its transcription start site which play a key role in glial-specific transcription…”
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