Search Results - "Knoblauch, Nicholas"

Computational pathology to discriminate benign from malignant intraductal proliferations of the breast by Dong, Fei, Irshad, Humayun, Oh, Eun-Yeong, Lerwill, Melinda F, Brachtel, Elena F, Jones, Nicholas C, Knoblauch, Nicholas W, Montaser-Kouhsari, Laleh, Johnson, Nicole B, Rao, Luigi K F, Faulkner-Jones, Beverly, Wilbur, David C, Schnitt, Stuart J, Beck, Andrew H

“…The categorization of intraductal proliferative lesions of the breast based on routine light microscopic examination of histopathologic sections is in many…”
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Sex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus) by Trainor, Brian C, Pride, Michael C, Villalon Landeros, Rosalina, Knoblauch, Nicholas W, Takahashi, Elizabeth Y, Silva, Andrea L, Crean, Katie K

“…Stressful life experiences are known to be a precipitating factor for many mental disorders. The social defeat model induces behavioral responses in rodents…”
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Detailed modeling of positive selection improves detection of cancer driver genes by Zhao, Siming, Liu, Jun, Nanga, Pranav, Liu, Yuwen, Cicek, A. Ercument, Knoblauch, Nicholas, He, Chuan, Stephens, Matthew, He, Xin

“…Identifying driver genes from somatic mutations is a central problem in cancer biology. Existing methods, however, either lack explicit statistical models, or…”
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Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype by Hefti, Marco M, Hu, Rong, Knoblauch, Nicholas W, Collins, Laura C, Haibe-Kains, Benjamin, Tamimi, Rulla M, Beck, Andrew H

“…Estrogen receptor (ER) and progesterone receptor (PR) testing are performed in the evaluation of breast cancer. While the clinical utility of ER as a…”
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Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function by Papa, Antonella, Wan, Lixin, Bonora, Massimo, Salmena, Leonardo, Song, Min Sup, Hobbs, Robin M., Lunardi, Andrea, Webster, Kaitlyn, Ng, Christopher, Newton, Ryan H., Knoblauch, Nicholas, Guarnerio, Jlenia, Ito, Keisuke, Turka, Laurence A., Beck, Andy H., Pinton, Paolo, Bronson, Roderick T., Wei, Wenyi, Pandolfi, Pier Paolo

“…PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here, we show that PTEN homodimerizes and, in this active…”
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The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration by Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas W, Beck, Andrew H, Toker, Alex

“…The PI3K-AKT signaling pathway regulates all phenotypes that contribute to progression of human cancers, including breast cancer. AKT mediates signal relay by…”
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Extensive rewiring of epithelial-stromal co-expression networks in breast cancer by Oh, Eun-Yeong, Christensen, Stephen M, Ghanta, Sindhu, Jeong, Jong Cheol, Bucur, Octavian, Glass, Benjamin, Montaser-Kouhsari, Laleh, Knoblauch, Nicholas W, Bertos, Nicholas, Saleh, Sadiq Mi, Haibe-Kains, Benjamin, Park, Morag, Beck, Andrew H

“…Epithelial-stromal crosstalk plays a critical role in invasive breast cancer pathogenesis; however, little is known on a systems level about how…”
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Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk by Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Li, Jingmei, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J. F., Heit, John A., Shane Pankratz, V., Norman, Aaron, Goode, Ellen L., Cunningham, Julie M., deAndrade, Mariza, Vierkant, Robert A., Czene, Kamila, Fasching, Peter A., Baglietto, Laura, Southey, Melissa C., Giles, Graham G., Shah, Kaanan P., Chan, Heang-Ping, Helvie, Mark A., Beck, Andrew H., Knoblauch, Nicholas W., Hazra, Aditi, Hunter, David J., Kraft, Peter, Pollan, Marina, Figueroa, Jonine D., Couch, Fergus J., Hopper, John L., Hall, Per, Easton, Douglas F., Boyd, Norman F., Vachon, Celine M., Tamimi, Rulla M.

“…Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast…”
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Significance analysis of prognostic signatures by Beck, Andrew H, Knoblauch, Nicholas W, Hefti, Marco M, Kaplan, Jennifer, Schnitt, Stuart J, Culhane, Aedin C, Schroeder, Markus S, Risch, Thomas, Quackenbush, John, Haibe-Kains, Benjamin

“…A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in…”
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Image-guided Coring for Large-scale Studies in Molecular Pathology by Montaser-Kouhsari, Laleh, Knoblauch, Nicholas W, Oh, Eun-Yeong, Baker, Gabrielle, Christensen, Stephen, Hazra, Aditi, Tamimi, Rulla M, Beck, Andrew H

“…Sampling of formalin-fixed paraffin-embedded (FFPE) tissue blocks is a critical initial step in molecular pathology. Image-guided coring (IGC) is a new method…”
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Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics by Morrison, Jean, Knoblauch, Nicholas, Marcus, Joseph H., Stephens, Matthew, He, Xin

“…Mendelian randomization (MR) is a valuable tool for detecting causal effects by using genetic variant associations. Opportunities to apply MR are growing…”
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Publisher Correction: Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics by Morrison, Jean, Knoblauch, Nicholas, Marcus, Joseph H., Stephens, Matthew, He, Xin

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A Statistical Framework for Mapping Risk Genes from De Novo Mutations in Whole-Genome-Sequencing Studies by Liu, Yuwen, Liang, Yanyu, Cicek, A. Ercument, Li, Zhongshan, Li, Jinchen, Muhle, Rebecca A., Krenzer, Martina, Mei, Yue, Wang, Yan, Knoblauch, Nicholas, Morrison, Jean, Zhao, Siming, Jiang, Yi, Geller, Evan, Ionita-Laza, Iuliana, Wu, Jinyu, Xia, Kun, Noonan, James P., Sun, Zhong Sheng, He, Xin

“…Analysis of de novo mutations (DNMs) from sequencing data of nuclear families has identified risk genes for many complex diseases, including multiple…”
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On Estimating the Genetic Basis of Complex Traits and Their Molecular Intermediates by Knoblauch, Nicholas Wilson

“…For a variant to have a causal effect on an organism-level trait, there must be a chain of causal events starting with the DNA-sequence, proceeding through one…”
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Abstract 3477: 3D morphological hallmarks of breast carcinogenesis: Diagnosis of non-invasive and invasive breast cancer with Lightsheet microscopy by Bucur, Octavian, Irshad, Humayun, Montaser-Kouhsari, Laleh, Knoblauch, Nicholas W., Oh, Eun-Yeong, Nowak, Jonathan, Beck, Andrew H.

“…Abstract BACKGROUND: Since the early 20th century, the pathological classification of breast cancer has been based primarily on the visual analysis of H&E…”
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Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth by Sakabe, Noboru J, Aneas, Ivy, Knoblauch, Nicholas, Sobreira, Debora R, Clark, Nicole, Paz, Cristina, Horth, Cynthia, Ziffra, Ryan, Kaur, Harjot, Liu, Xiao, Anderson, Rebecca, Morrison, Jean, Cheung, Virginia C, Grotegut, Chad, Reddy, Timothy E, Jacobsson, Bo, Hallman, Mikko, Teramo, Kari, Murtha, Amy, Kessler, John, Grobman, William, Zhang, Ge, Muglia, Louis J, Rana, Sarosh, Lynch, Vincent J, Crawford, Gregory E, Ober, Carole, He, Xin, Nóbrega, Marcelo A

“…While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular…”
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Application of Image‐Guided Coring as a new technique for targeting breast tumor tissue in molecular pathology by Montaser‐Kouhsari, Laleh, Christensen, Stephen, Knoblauch, Nicholas W, Baker, Gabrielle, Beck, Andrew H

“…Abstract only Background There are several techniques available to sample tissue from archival formalin‐fixed paraffin‐embedded (FFPE) tissue blocks. However,…”
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Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk (vol 5, 5303, 2014) by Lindstroem, S, Thompson, DJ, Paterson, AD, Li, J, Gierach, GL, Scott, C, Stone, J, Douglas, JA, dos-Santos-Silva, I, Fernandez-Navarro, P

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Correction: Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk by Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Li, Jingmei, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J. F., Heit, John A., Pankratz, V. Shane, Norman, Aaron, Goode, Ellen L., Cunningham, Julie M., deAndrade, Mariza, Vierkant, Robert A., Czene, Kamila, Fasching, Peter A., Baglietto, Laura, Southey, Melissa C., Giles, Graham G., Shah, Kaanan P., Chan, Heang-Ping, Helvie, Mark A., Beck, Andrew H., Knoblauch, Nicholas W., Hazra, Aditi, Hunter, David J., Kraft, Peter, Pollan, Marina, Figueroa, Jonine D., Couch, Fergus J., Hopper, John L., Hall, Per, Easton, Douglas F., Boyd, Norman F., Vachon, Celine M., Tamimi, Rulla M.

“…Nature Communications 5 Article number: 5303 (2014); Published: 24 October 2014; Updated: 9 September 2015 The financial support for this Article was not fully…”
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Corrigendum: genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk by Lindström, Sara, Thompson, Deborah J, Paterson, Andrew D, Li, Jingmei, Gierach, Gretchen L, Scott, Christopher, Stone, Jennifer, Douglas, Julie A, Dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J, Loos, Ruth J F, Heit, John A, Pankratz, V Shane, Norman, Aaron, Goode, Ellen L, Cunningham, Julie M, deAndrade, Mariza, Vierkant, Robert A, Czene, Kamila, Fasching, Peter A, Baglietto, Laura, Southey, Melissa C, Giles, Graham G, Shah, Kaanan P, Chan, Heang-Ping, Helvie, Mark A, Beck, Andrew H, Knoblauch, Nicholas W, Hazra, Aditi, Hunter, David J, Kraft, Peter, Pollan, Marina, Figueroa, Jonine D, Couch, Fergus J, Hopper, John L, Hall, Per, Easton, Douglas F, Boyd, Norman F, Vachon, Celine M, Tamimi, Rulla M

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