Search Results - "Knobeloch, Klaus–Peter"

Novel Hexb-based tools for studying microglia in the CNS by Masuda, Takahiro, Amann, Lukas, Sankowski, Roman, Staszewski, Ori, Lenz, Maximilian, d´Errico, Paolo, Snaidero, Nicolas, Costa Jordão, Marta Joana, Böttcher, Chotima, Kierdorf, Katrin, Jung, Steffen, Priller, Josef, Misgeld, Thomas, Vlachos, Andreas, Meyer-Luehmann, Melanie, Knobeloch, Klaus-Peter, Prinz, Marco

“…Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as perivascular and meningeal macrophages, are implicated in virtually all…”
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Genetic targeting of microglia by Wieghofer, Peter, Knobeloch, Klaus-Peter, Prinz, Marco

“…Genetic targeting of microglia and other myeloid cells in the central nervous system (CNS) is highly desirable as they are critical effectors and regulators of…”
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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions by Schwabenland, Marius, Salié, Henrike, Tanevski, Jovan, Killmer, Saskia, Lago, Marilyn Salvat, Schlaak, Alexandra Emilia, Mayer, Lena, Matschke, Jakob, Püschel, Klaus, Fitzek, Antonia, Ondruschka, Benjamin, Mei, Henrik E., Boettler, Tobias, Neumann-Haefelin, Christoph, Hofmann, Maike, Breithaupt, Angele, Genc, Nafiye, Stadelmann, Christine, Saez-Rodriguez, Julio, Bronsert, Peter, Knobeloch, Klaus-Peter, Blank, Thomas, Thimme, Robert, Glatzel, Markus, Prinz, Marco, Bengsch, Bertram

“…COVID-19 can cause severe neurological symptoms, but the underlying pathophysiological mechanisms are unclear. Here, we interrogated the brain stems and…”
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Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation by Held, Tobias, Basler, Michael, Knobeloch, Klaus‐Peter, Groettrup, Marcus

“…The IFN stimulated gene 15 (ISG15) encodes a 15‐kDa ubiquitin‐like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized…”
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How USP18 deals with ISG15‐modified proteins: structural basis for the specificity of the protease by Basters, Anja, Knobeloch, Klaus‐Peter, Fritz, Günter

“…The ubiquitin‐specific protease 18 (USP18) has two major functions: (a) it is a highly specific protease that cleaves the ubiquitin‐like modifier ISG15…”
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain by Goldmann, Tobias, Zeller, Nicolas, Raasch, Jenni, Kierdorf, Katrin, Frenzel, Kathrin, Ketscher, Lars, Basters, Anja, Staszewski, Ori, Brendecke, Stefanie M, Spiess, Alena, Tay, Tuan Leng, Kreutz, Clemens, Timmer, Jens, Mancini, Grazia MS, Blank, Thomas, Fritz, Günter, Biber, Knut, Lang, Roland, Malo, Danielle, Merkler, Doron, Heikenwälder, Mathias, Knobeloch, Klaus-Peter, Prinz, Marco

“…Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a…”
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SCFFbxw5 targets kinesin‐13 proteins to facilitate ciliogenesis by Schweiggert, Jörg, Habeck, Gregor, Hess, Sandra, Mikus, Felix, Beloshistov, Roman, Meese, Klaus, Hata, Shoji, Knobeloch, Klaus‐Peter, Melchior, Frauke

“…Microtubule depolymerases of the kinesin‐13 family play important roles in various cellular processes and are frequently overexpressed in different cancer…”
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The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection by Zhang, Yifeng, Thery, Fabien, Wu, Nicholas C., Luhmann, Emma K., Dussurget, Olivier, Foecke, Mariko, Bredow, Clara, Jiménez-Fernández, Daniel, Leandro, Kevin, Beling, Antje, Knobeloch, Klaus-Peter, Impens, Francis, Cossart, Pascale, Radoshevich, Lilliana

“…ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity. Here, we map the endogenous in vivo ISGylome in the…”
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HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia by Troilo, Albino, Alexander, Irina, Muehl, Sarah, Jaramillo, Daniela, Knobeloch, Klaus-Peter, Krek, Wilhelm

“…Loss of primary cilia is a key feature of von Hippel‐Lindau tumor suppressor ( VHL )‐associated pathology. Although VHL ‐deficiency predisposes cells to…”
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Structural basis of the specificity of USP18 toward ISG15 by Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter

“…The specificity of USP18's deconjugating activity toward ISG15, a ubiquitin-like protein induced by interferon, is revealed by structural and biochemistry…”
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A comparative analysis of microglial inducible Cre lines by Faust, Travis E., Feinberg, Philip A., O’Connor, Ciara, Kawaguchi, Riki, Chan, Andrew, Strasburger, Hayley, Frosch, Maximilian, Boyle, Margaret A., Masuda, Takahiro, Amann, Lukas, Knobeloch, Klaus-Peter, Prinz, Marco, Schaefer, Anne, Schafer, Dorothy P.

“…Cre/loxP technology has revolutionized genetic studies and allowed for spatial and temporal control of gene expression in specific cell types. Microglial…”
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In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases by Campos Alonso, Marta, Knobeloch, Klaus-Peter

“…Proteases that cleave ubiquitin or ubiquitin-like proteins (UBLs) are critical players in maintaining the homeostasis of the organism. Concordantly, their…”
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Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance by Ketscher, Lars, Hannß, Ronny, Morales, David J., Basters, Anja, Guerra, Susana, Goldmann, Tobias, Hausmann, Annika, Prinz, Marco, Naumann, Ronald, Pekosz, Andrew, Utermöhlen, Olaf, Lenschow, Deborah J., Knobeloch, Klaus-Peter

“…Significance Viral infections still constitute a major health issue. Upon viral infection, interferon (IFN) elicits an antiviral response by activating…”
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Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity by Peschke, Katrin, Achleitner, Martin, Frenzel, Kathrin, Gerbaulet, Alexander, Ada, Servi Remzi, Zeller, Nicolas, Lienenklaus, Stefan, Lesche, Mathias, Poulet, Claire, Naumann, Ronald, Dahl, Andreas, Ravens, Ursula, Günther, Claudia, Müller, Werner, Knobeloch, Klaus-Peter, Prinz, Marco, Roers, Axel, Behrendt, Rayk

“…Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condition Aicardi-Goutières syndrome and are associated with…”
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Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System by Prinz, Marco, Schmidt, Hauke, Mildner, Alexander, Knobeloch, Klaus-Peter, Hanisch, Uwe-Karsten, Raasch, Jenni, Merkler, Doron, Detje, Claudia, Gutcher, Ilona, Mages, Jörg, Lang, Roland, Martin, Roland, Gold, Ralf, Becher, Burkhard, Brück, Wolfgang, Kalinke, Ulrich

“…The action of type I interferons in the central nervous system (CNS) during autoimmunity is largely unknown. Here, we demonstrate elevated interferon beta…”
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Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication by Herzog, Anna-Maria, Göbel, Katharina, Marongiu, Luigi, Ruetalo, Natalia, Alonso, Marta Campos, Leischner, Christian, Busch, Christian, Burkard, Markus, Lauer, Ulrich M, Geurink, Paul P, Knobeloch, Klaus-Peter, Schindler, Michael, Fritz, Günter, Venturelli, Sascha

“…Selected natural compounds exhibit very good antiviral properties. Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant…”
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Strategies to Target ISG15 and USP18 Toward Therapeutic Applications by Jiménez Fernández, Daniel, Hess, Sandra, Knobeloch, Klaus-Peter

“…The interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like protein (Ubl), which in a process termed ISGylation can be covalently…”
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Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties by Xin, Bo-Tao, Gan, Jin, Fernandez, Daniel J, Knobeloch, Klaus-Peter, Geurink, Paul P, Ovaa, Huib

“…The linear synthesis of the N-terminal domain of mISG15 has been developed which enables the synthesis of full-length mISG15 and the activity-based probe…”
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Molecular characterization of ubiquitin‐specific protease 18 reveals substrate specificity for interferon‐stimulated gene 15 by Basters, Anja, Geurink, Paul P., El Oualid, Farid, Ketscher, Lars, Casutt, Marco S., Krause, Eberhard, Ovaa, Huib, Knobeloch, Klaus‐Peter, Fritz, Günter

“…Protein modification by interferon‐stimulated gene 15 (ISG15), an ubiquitin‐like modifier, affects multiple cellular functions and represents one of the major…”
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IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses by Lenschow, Deborah J, Lai, Caroline, Frias-Staheli, Natalia, Giannakopoulos, Nadia V, Lutz, Andrew, Wolff, Thorsten, Osiak, Anna, Levine, Beth, Schmidt, Robert E, García-Sastre, Adolfo, Leib, David A, Pekosz, Andrew, Knobeloch, Klaus-Peter, Horak, Ivan, Virgin, Herbert Whiting IV

“…Type I interferons (IFNs) play an essential role in the host response to viral infection through the induction of numerous IFN-stimulated genes (ISGs),…”
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