Search Results - "Knobel, Susan M."

Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus by Alcendor, Donald J, Charest, Ashley M, Zhu, Wen Qin, Vigil, Hollie E, Knobel, Susan M

“…Congenital human cytomegalovirus (HCMV) infections can result in CNS abnormalities in newborn babies including vision loss, mental retardation, motor deficits,…”
Get full text

Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion by Brissova, Marcela, Shiota, Masakazu, Nicholson, Wendell E., Gannon, Maureen, Knobel, Susan M., Piston, David W., Wright, Christopher V.E., Powers, Alvin C.

“…Complete lack of transcription factor PDX-1 leads to pancreatic agenesis, whereas heterozygosity for PDX-1 mutations has been recently noted in some…”
Get full text

Separation of the Glucose-Stimulated Cytoplasmic and Mitochondrial NAD(P)H Responses in Pancreatic Islet β Cells by Patterson, George H., Knobel, Susan M., Arkhammar, Per, Thastrup, Ole, Piston, David W.

“…Two-photon excitation microscopy was used to image and quantify NAD(P)H autofluorescence from intact pancreatic islets under glucose stimulation. At maximal…”
Get full text

Oxidative Stress Is a Mediator of Glucose Toxicity in Insulin-secreting Pancreatic Islet Cell Lines by Wu, Lan, Nicholson, Wendell, Knobel, Susan M., Steffner, Robert J., May, James M., Piston, David W., Powers, Alvin C.

“…Pancreatic β cells secrete insulin in response to changes in the extracellular glucose. However, prolonged exposure to elevated glucose exerts toxic effects on…”
Get full text

Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis by Marrs, Christy N., Knobel, Susan M., Zhu, Wen Qin, Sweet, Stephanie D., Chaudhry, Ahsen R., Alcendor, Donald J.

“…Bacterial vaginosis (BV), a common condition seen in premenopausal women, is associated with preterm labor, pelvic inflammatory disease, and delivery of low…”
Get full text

KSHV downregulation of galectin-3 in Kaposi's sarcoma by Alcendor, Donald J, Knobel, Susan M, Desai, Prashant, Zhu, Wen Q, Vigil, Hollie E, Hayward, Gary S

“…Galectins are a family of proteins that share an affinity for beta-galactoside containing glycoconjugates. In prostate, ovarian and breast cancer,…”
Get full text

Adenovirus-mediated Knockout of a Conditional Glucokinase Gene in Isolated Pancreatic Islets Reveals an Essential Role for Proximal Metabolic Coupling Events in Glucose-stimulated Insulin Secretion by Piston, David W., Knobel, Susan M., Postic, Catherine, Shelton, Kathy D., Magnuson, Mark A.

“…The relationship between glucokinase (GK) and glucose-stimulated metabolism, and the potential for metabolic coupling between β cells, was examined in isolated…”
Get full text

Real-time Analysis of Glucose Metabolism by Microscopy by Piston, David W, Knobel, Susan M

“…Glucose metabolism has traditionally been assayed via biochemical means. Fluorescence monitoring of NAD(P)H levels has provided a non-invasive method to assay…”
Get full text

Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting steps by Perriott, L M, Kono, T, Whitesell, R R, Knobel, S M, Piston, D W, Granner, D K, Powers, A C, May, J M

“…To use primary cultures of human skeletal muscle cells to establish defects in glucose metabolism that underlie clinical insulin resistance, it is necessary to…”
Get more information

Control of glucose phosphorylation in L6 myotubes by compartmentalization, hexokinase, and glucose transport by Whitesell, Richard R, Ardehali, Hossein, Printz, Richard L, Beechem, Joseph M, Knobel, Susan M, Piston, David W, Granner, Daryl K, Van Der Meer, Wieb, Perriott, Laureta M, May, James M

“…In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK). While effects of insulin on glucose transport…”
Get full text

Induction of aP2 Gene Expression by Nonmetabolized Long-Chain Fatty Acids by Grimaldi, Paul A., Knobel, Susan M., Whitesell, Richard R., Abumrad, Nada A.

“…Long-chain fatty acids (FA) have been shown to regulate expression of the gene for the adipocyte FA-binding protein aP2. We examined whether this effect was…”
Get full text

Use of the green fluorescent protein and its mutants in quantitative fluorescence microscopy by Patterson, G.H., Knobel, S.M., Sharif, W.D., Kain, S.R., Piston, D.W.

“…We have investigated properties relevant to quantitative imaging in living cells of five green fluorescent protein (GFP) variants that have been used…”
Get full text

Abstract B53: KSHV regulation of fibulins in Kaposi's sarcoma (KS): Implications for the role of the extracellular matrix in KS tumorigenesis by Alcendor, Donald J., Knobel, Susan M., Zhu, Wen Q., Desai, Prashant, Hayward, Gary S.

“…Abstract Introduction: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of KS, which is the leading cause of cancer and cancer related…”
Get full text

Biphasic changes in phospholipid hydroperoxide levels during renal ischemia/reperfusion by Beckman, J K, Yoshioka, T, Knobel, S M, Greene, H L

“…The involvement of lipid peroxidation in renal ischemia/reperfusion was explored by measuring changes in the cortical content of specific primary lipid…”
Get more information

Quantitative imaging of metabolism by two-photon excitation microscopy by Piston, D W, Knobel, S M

Get more information

Quantitative imaging of the green fluorescent protein (GFP) by Piston, D W, Patterson, G H, Knobel, S M

Get more information

Molecular Cloning, Sequencing, Chromosomal Localization, and Tissue Distribution of the Human Na+/H+Exchanger (SLC9A2) by GHISHAN, FAYEZ K., KNOBEL, SUSAN M., SUMMAR, MARSHALL

“…The Na+/H+exchangers belong to a family of transport proteins involved in intracellular pH regulation and vectorial sodium transport across various epithelial…”
Get full text

Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition by Jetton, T L, Shiota, M, Knobel, S M, Piston, D W, Cherrington, A D, Magnuson, M A

“…Hepatic glucokinase (GK) is acutely regulated by binding to its nuclear-anchored regulatory protein (GKRP). Although GK release by GKRP is tightly coupled to…”
Get full text

Kinetic characterization of a stably expressed novel Na+/H+ exchanger (NHE-2) by Honda, T, Knobel, S M, Bulus, N M, Ghishan, F K

“…We have recently reported the molecular cloning, sequencing and tissue distribution of a novel Na+/H+ exchanger (NHE-2). The cDNA for NHE-2 was cloned by…”
Get more information