Search Results - "Knittel, J.J."

Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH2 by KOIKOV, L. N, EBETINO, F. H, SOLINSKY, M. G, CROSS-DOERSEN, D, KNITTEL, J. J

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Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH 2) 3CO-His- d-Phe-Arg-Trp-NH 2]. An additional binding site within the human melanocortin receptor 1? by Koikov, L.N, Ebetino, F.H, Solinsky, M.G, Cross-Doersen, D, Knittel, J.J

“…Of the 29 analogs of LK-184 ( 1) tested at the human MC1, MC3, and MC4 receptors (R), only LK-312 ( 3), partially mimicking the π-system of 1, had an EC 50 of…”
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End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists by KOIKOV, L. N, EBETINO, F. H, HAYES, J. C, CROSS-DOERSEN, D, KNITTEL, J. J

“…Of the 42 R'-X-(p-Cl)Phe-D-Phe-Arg-Trp-NH(2) (X=CO, SO(2), PO, PS) tested at the human (h)MC1, hMC3, and hMC4 receptors (R), the most potent MC4R agonists…”
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Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis by Hertelendy, Z.I., Patel, D.G., Knittel, J.J.

“…To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and…”
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End-capping of the modified melanocortin tetrapeptide ( p-Cl)Phe- D-Phe-Arg-Trp-NH 2 as a route to hMC4R agonists by Koikov, L.N., Ebetino, F.H., Hayes, J.C., Cross-Doersen, D., Knittel, J.J.

“…Of the 42 R′-X-( p-Cl)Phe- D-Phe-Arg-Trp-NH 2 (X = CO, SO 2, PO, PS) tested on the human (h)MC1, hMC3, and hMC4 receptors (R), the most potent MC4R agonists…”
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Sub-Nanomolar hMC1R Agonists by End-Capping of the Melanocortin Tetrapeptide His- d-Phe-Arg-Trp-NH 2 by Koikov, L.N, Ebetino, F.H, Solinsky, M.G, Cross-Doersen, D, Knittel, J.J

“…Twenty three derivatives of the core fragment His 6- d-Phe 7-Arg 8-Trp 9-NH 2 end-capped with carboxylic and sulfonic acids were synthesized and evaluated at…”
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Detection of conformational isomers of anglerfish peptide YG (aPY) by reversed phase chromatography by Balasubramaniam, A, Knittel, J J, Gil, C, Andrews, P C

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